| Entry |
|
|---|
| Name |
Daunorubicin citrate;
Daunoxome (TN) |
|---|
| Formula |
C27H29NO10. C6H8O7
|
|---|
| Exact mass |
719.2061
|
|---|
| Mol weight |
719.6434
|
|---|
| Structure |
|
|---|
| Class |
Antineoplastic
DG01682 Anthracycline antineoplastic
DG01529 Topoisomerase inhibitor
DG01527 Topoisomerase II inhibitor
|
|---|
| Remark |
| Product (DG00697): | D01264<JP/US> |
|
|---|
| Efficacy |
Antineoplastic, Topoisomerase II inhibitor |
|---|
| Comment |
Treatment of advanced HIV-associated Kaposi's sarcoma
|
|---|
| Target |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01D CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
L01DB Anthracyclines and related substances
L01DB02 Daunorubicin
D10787 Daunorubicin citrate
Drug groups [BR:br08330]
Antineoplastic
DG01682 Anthracycline antineoplastic
DG00697 Daunorubicin
D10787 Daunorubicin citrate
DG01529 Topoisomerase inhibitor
DG01527 Topoisomerase II inhibitor
DG00697 Daunorubicin
D10787 Daunorubicin citrate
Target-based classification of drugs [BR:br08310]
Enzymes
Isomerases (EC5)
DNA topoisomerase
TOP2
D10787 Daunorubicin citrate
Drug groups [BR:br08330]
Antineoplastic
DG01682 Anthracycline antineoplastic
DG00697 Daunorubicin
DG01529 Topoisomerase inhibitor
DG01527 Topoisomerase II inhibitor
DG00697 Daunorubicin
|
|---|
| Other DBs |
|
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| LinkDB |
|
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| KCF data |
ATOM 51
1 C8x C 11.9537 -13.3518
2 C8x C 11.9537 -14.7499
3 C8y C 13.1421 -15.4489
4 C8y C 14.4003 -14.7499
5 C8y C 14.4003 -13.3518
6 C8x C 13.1421 -12.6527
7 C5x C 15.5887 -15.4489
8 C8y C 16.7771 -14.7499
9 C8y C 16.7771 -13.3518
10 C5x C 15.5887 -12.6527
11 C8y C 18.0354 -15.4489
12 C8y C 19.2238 -14.7499
13 C8y C 19.2238 -13.3518
14 C8y C 18.0354 -12.6527
15 C1y C 20.4121 -15.4489
16 C1x C 21.6704 -14.7499
17 C1z C 21.6704 -13.3518
18 C1x C 20.4121 -12.6527
19 O2a O 13.1421 -16.8470
20 C1a C 11.9537 -17.5461
21 O5x O 15.5887 -16.8470
22 O5x O 15.5887 -11.2546
23 O1a O 18.0354 -11.2546
24 O1a O 18.0354 -16.8470
25 O2a O 20.4121 -16.8470
26 C1y C 21.6005 -17.5461
27 C5a C 22.8588 -12.6527
28 C1a C 24.0472 -13.3518
29 O5a O 22.8588 -11.2546
30 O1a O 22.8588 -14.2605
31 C1x C 21.6005 -18.9441
32 C1y C 22.8588 -19.6432
33 C1y C 24.0472 -18.9441
34 C1y C 24.0472 -17.5461
35 O2x O 22.8588 -16.8470
36 N1a N 22.8588 -21.0413
37 C1a C 25.2356 -16.8470
38 O1a O 25.2356 -19.6432
39 C6a C 30.2648 -16.0461
40 C1b C 31.4561 -16.7469
41 O6a O 29.0035 -16.7469
42 O6a O 30.2648 -14.6446
43 C1d C 32.6473 -16.0461
44 C1b C 33.8386 -16.7469
45 C6a C 33.8386 -18.1483
46 O6a O 32.5772 -18.9191
47 O6a O 35.0298 -18.8491
48 C6a C 33.3480 -14.8549
49 O6a O 32.6473 -13.6636
50 O6a O 34.7495 -14.8549
51 O1a O 31.9466 -14.8549
BOND 54
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 8 11 2
13 11 12 1
14 12 13 2
15 13 14 1
16 9 14 2
17 12 15 1
18 15 16 1
19 16 17 1
20 17 18 1
21 13 18 1
22 3 19 1
23 19 20 1
24 7 21 2
25 10 22 2
26 14 23 1
27 11 24 1
28 26 25 1 #Down
29 15 25 1 #Down
30 17 27 1 #Up
31 27 28 1
32 27 29 2
33 17 30 1 #Down
34 26 31 1
35 31 32 1
36 32 33 1
37 33 34 1
38 34 35 1
39 26 35 1
40 32 36 1 #Up
41 34 37 1 #Up
42 33 38 1 #Up
43 39 40 1
44 39 41 1
45 39 42 2
46 40 43 1
47 43 44 1
48 44 45 1
49 45 46 2
50 45 47 1
51 43 48 1
52 48 49 1
53 48 50 2
54 43 51 1
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|---|
