KEGG   DRUG: Olipudase alfa
Entry
D10820                      Drug                                   
Name
Olipudase alfa (USAN/INN);
Olipudase alfa (genetical recombination) (JAN);
Olipudase alfa-rpcp;
Xenpozyme (TN)
Product
XENPOZYME (Genzyme Corporation)
Formula
C2900H4373N783O791S24
Exact mass
63590.933
Mol weight
63631.0831
Sequence
HPLSPQGHPA RLHRIVPRLR DVFGWGNLTC PICKGLFTAI NLGLKKEPNV ARVGSVAIKL
CNLLKIAPPA VCQSIVHLFE DDMVEVWRRS VLSPSEACGL LLGSTCGHWD IFSSWNISLP
TVPKPPPKPP SPPAPGAPVS RILFLTDLHW DHDYLEGTDP DCADPLCCRR GSGLPPASRP
GAGYWGEYSK CDLPLRTLES LLSGLGPAGP FDMVYWTGDI PAHDVWHQTR QDQLRALTTV
TALVRKFLGP VPVYPAVGNH ESTPVNSFPP PFIEGNHSSR WLYEAMAKAW EPWLPAEALR
TLRIGGFYAL SPYPGLRLIS LNMNFCSREN FWLLINSTDP AGQLQWLVGE LQAAEDRGDK
VHIIGHIPPG HCLKSWSWNY YRIVARYENT LAAQFFGHTH VDEFEVFYDE ETLSRPLAVA
FLAPSATTYI GLNPGYRVYQ IDGNYSGSSH VVLDHETYIL NLTQANIPGA IPHWQLLYRA
RETYGLPNTL PTAWHNLVYR MRGDMQLFQT FWFLYHKGHP PSEPCGTPCR LATLCAQLSA
RADSPALCRH LMPDGSLPEA QSLWPRPLFC
(Disulfide bridge: 43-119, 46-111, 74-85, 175-180, 181-204, 339-385, 538-542, 548-561)
  Type
Peptide
Remark
Therapeutic category: 3959
ATC code: A16AB25
Product: D10820<JP/US>
Efficacy
Lysosomal storage disease treatment, Enzyme replacement (acid sphingomyelinase)
  Disease
Acid sphingomyelinase deficiency [DS:H00137]
  Type
Enzyme replacement therapy product
Comment
Treatment of Niemann-Pick disease type A/B
Target
SMPD1* [HSA_VAR:6609v1] [HSA:6609] [KO:K12350]
  Pathway
hsa00600  Sphingolipid metabolism
hsa04071  Sphingolipid signaling pathway
hsa04142  Lysosome
  Network
nt06014  Sphingolipid degradation
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AB Enzymes
     A16AB25 Olipudase alfa
      D10820  Olipudase alfa (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Genetic, Enzyme, or Protein Disorder: Replacement, Modifiers, Treatment
  Olipudase Alfa
   D10820  Olipudase alfa (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   395  Enzyme preparations
    3959  Others
     D10820  Olipudase alfa (USAN/INN); Olipudase alfa (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Phosphodiesterases
    SMPD1* [HSA_VAR:6609v1]
     D10820  Olipudase alfa (USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10820
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10820
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10820
Pharmacogenomic biomarkers [br08341.html]
 Germline mutations in genetic disorder treatments
  D10820
Other DBs
CAS: 927883-84-9
PubChem: 319902620
LinkDB

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