KEGG   DRUG: Zilucoplan sodium
Entry
D12356                      Drug                                   
Name
Zilucoplan sodium (JAN);
Zilbrysq (TN)
Product
Formula
C172H274N24O55. 4Na
Exact mass
3647.8972
Mol weight
3650.1028
Class
Metabolizing enzyme substrate
 DG02980  CYP4F2 substrate
Remark
Therapeutic category: 3999
ATC code: L04AJ06
Chemical structure group: DG03224
Product (DG03224): D12356<JP/US>
Efficacy
Autoimmune disease treatment, Complement C5 inhibitor
  Disease
Generalized myasthenia gravis (antiacetylcholine receptor antibody positive) [DS:H01594]
Target
C5 [HSA:727] [KO:K03994]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04610  Complement and coagulation cascades
hsa04613  Neutrophil extracellular trap formation
Metabolism
Enzyme: CYP4F2 [HSA:8529]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AJ Complement inhibitors
     L04AJ06 Zilucoplan
      D12356  Zilucoplan sodium (JAN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D12356  Zilucoplan sodium (JAN)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG02980  CYP4F2 substrate
   DG03224  Zilucoplan
    D12356  Zilucoplan sodium
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Organismal systems
   Complement and coagulation
    C5
     D12356  Zilucoplan sodium (JAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D12356
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D12356
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D12356
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D12356
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D12356
Pharmacogenomic biomarkers [br08341.html]
 Somatic variations in targeted cancer therapies
  D12356
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG02980  CYP4F2 substrate
   DG03224  Zilucoplan
Other DBs
ChEBI: 229660
LinkDB

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