KEGG   DRUG: Zagociguat
Entry
D12516                      Drug                                   
Name
Zagociguat (USAN/INN)
Formula
C16H10F4N6
Exact mass
362.0903
Mol weight
362.2844
Structure
Class
Cardiovascular agent
 DG03006  Guanylate cyclase activator
Efficacy
Neurodegenerative diseases agent, Guanylate cyclase activator
Comment
Treatment of serious neurodegenerative disorders including mitochondrial disease, Alzheimer's disease (AD), and cognitive impairment associated with schizophrenia
Target
GUCY1A [HSA:2977 2982] [KO:K12318]
GUCY1B [HSA:2983] [KO:K12319]
  Pathway
hsa00230  Purine metabolism
hsa04022  cGMP-PKG signaling pathway
hsa04540  Gap junction
hsa04730  Long-term depression
Interaction
Brite
Drug groups [BR:br08330]
 Cardiovascular agent
  DG03006  Guanylate cyclase activator
   D12516  Zagociguat
Target-based classification of drugs [BR:br08310]
 Enzymes
  Lyases (EC4)
   Phosphorus-oxygen lyases
    GUCY1A
     D12516  Zagociguat (USAN/INN)
    GUCY1B
     D12516  Zagociguat (USAN/INN)
Other DBs
CAS: 2201048-82-8
LinkDB
KCF data

ATOM        26
            1   C8x C    18.0057  -15.6326
            2   N5x N    15.7724  -15.7024
            3   C8y C    16.1912  -16.9586
            4   N4y N    17.5869  -16.9586
            5   C8x C    16.8890  -14.7952
            6   C8y C    15.5631  -18.2148
            7   N5x N    16.2609  -19.4012
            8   C8y C    17.6567  -19.4012
            9   C8x C    18.3546  -18.1450
            10  C1b C    14.1414  -18.1934
            11  C8y C    13.4200  -19.4007
            12  C8x C    12.0400  -19.3798
            13  C8x C    11.3217  -20.5815
            14  C8x C    12.0033  -21.8044
            15  C8x C    13.3833  -21.8253
            16  C8y C    14.1016  -20.6236
            17  X   F    15.4700  -20.6449
            18  C8y C    18.3574  -20.5922
            19  N4x N    17.8001  -21.8717
            20  C8y C    18.8448  -22.7971
            21  N5x N    20.0477  -22.0895
            22  N5x N    19.7464  -20.7268
            23  C1d C    18.7076  -24.2146
            24  X   F    17.4168  -24.8022
            25  X   F    19.8378  -25.0217
            26  X   F    18.7076  -25.6146
BOND        29
            1     2   3 2
            2     3   4 1
            3     4   1 1
            4     1   5 2
            5     2   5 1
            6     3   6 1
            7     6   7 2
            8     7   8 1
            9     8   9 2
            10    4   9 1
            11    6  10 1
            12   10  11 1
            13   11  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   11  16 1
            19   16  17 1
            20    8  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 2
            24   21  22 1
            25   18  22 2
            26   20  23 1
            27   23  24 1
            28   23  25 1
            29   23  26 1

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