Plague

Plague is a deadly infectious disease caused by Yersinia pestis. The pathogen has rodent reservoirs and is transmitted to humans usually by fleas as vectors. There are three major manifestations: bubonic, septicemic, and pneumonic plagues. Severe epidemics in the past include the Plague of Justinian in the sixth century, the Black Death in the fourteenth century, and the Third Pandemic that began in Central Asia in the nineteenth century. The genome sequences have been determined for the strains responsible for these epidemics.

Bacterial infectious disease

nt06517 TLR signaling
nt06521 NLR signaling
nt06537 TCR/BCR signaling

Yersinia pestis CO92 (biovar Orientalis) [GN:ype] (Third Pandemic)
Yersinia pestis KIM (biovar Mediaevalis) [GN:ypk] (Black Death)
Yersinia pestis Antiqua,Nepal516 (biovar Antiqua) [GN:ypa ypn] (Plague of Justinian)
Yersinia pestis Pestoides F [GN:ypp]
Yersinia pestis Angola [GN:ypg]
Yersinia pestis D106004 [GN:ypd]
Yersinia pestis D182038 [GN:ypx]

Tetracycline hydrochloride [DR:D02122]
Doxycycline [DR:D00307]
Doxycycline hyclate [DR:D02129]
Doxycycline calcium [DR:D03903]
Minocycline hydrochloride [DR:D00850]
Streptomycin sulfate [DR:D01350]
Demeclocycline hydrochloride [DR:D00290]
Ciprofloxacin [DR:D00186]
Ciprofloxacin hydrochloride [DR:D02216]
Levofloxacin [DR:D00588]
Moxifloxacin hydrochloride [DR:D00874]

Vector: Xenopsylla cheopis (rat flea)
murine toxin [KO:K11009]

Yersiniosis

Yersiniosis (non-plague) is an infectious disease caused by two species, Yersinia enterocolitica and Y. pseudotuberculosis, which is zoonotic, capable of being transmitted from infected animals to man. Routes of transmission include fecal-oral spread via ingestion of contaminated food as the most common route and consumption of contaminated water supplies. Yersiniosis occurs more commonly in regions with temperate rather than tropical or subtropical climates.

Bacterial infectious disease

nt06183 Yersinia
nt06517 TLR signaling
nt06521 NLR signaling
nt06537 TCR/BCR signaling

Yersinia pseudotuberculosis [GN:yps ypi ypq]
Yersinia enterocolitica [GN:yen yep yey yef]
superantigen [KO:K11010]

PMID:10192708

PMID:15721832