KEGG   DISEASE: Spotted fever
Entry
H00323                      Disease                                
Name
Spotted fever;
Tick-borne rickettsioses
Description
Tick-borne rickettsioses are caused by gram-negative obligate intracellular bacteria belonging to the spotted fever group (SFG) of the genus Rickettsia within the family Rickettsiaceae in the order Rickettsiales. The diseases present with high fever, an inoculation eschar, and a maculopapular rash.
Category
Bacterial infectious disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Other bacterial diseases
   Rickettsioses
    1C31  Spotted fever
     H00323  Spotted fever
Genome-based classification of infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by alpha proteobacteria
   H00323  Spotted fever
Pathogen
Rickettsia rickettsii [GN:rri] (Rocky Mountain spotted fever)
Rickettsia conorii [GN:rco] (African tick typhus / Boutonneuse fever)
Rickettsia felis [GN:rfe] (flea-borne spotted fever)
Rickettsia sibirica (North Asian tick fever / Siberian tick typhus)
Rickettsia massiliae [GN:rms]
Rickettsia africae [GN:raf]
Rickettsia japonica [GN:rja] (Japanese spotted fever)
Rickettsia heilongjiangensis [GN:rhe] (Far-Eastern spotted fever)
Drug
Tetracycline hydrochloride [DR:D02122]
Doxycycline [DR:D00307]
Doxycycline hyclate [DR:D02129]
Doxycycline calcium [DR:D03903]
Minocycline hydrochloride [DR:D00850]
Demeclocycline hydrochloride [DR:D00290]
Comment
Vectors: Rhipicephalus sanguineus (brown dog tick) for Rickettsia conorii
Other DBs
ICD-11: 1C31
ICD-10: A77
MeSH: D012373 D001907
MedlinePlus: 000654
Reference
PMID:16223955
  Authors
Parola P, Paddock CD, Raoult D
  Title
Tick-borne rickettsioses around the world: emerging diseases challenging old concepts.
  Journal
Clin Microbiol Rev 18:719-56 (2005)
DOI:10.1128/CMR.18.4.719-756.2005
Reference
PMID:19358804
  Authors
Socolovschi C, Mediannikov O, Raoult D, Parola P
  Title
The relationship between spotted fever group Rickettsiae and ixodid ticks.
  Journal
Vet Res 40:34 (2009)
DOI:10.1051/vetres/2009017
Reference
PMID:15225980
  Authors
Parola P
  Title
Tick-borne rickettsial diseases: emerging risks in Europe.
  Journal
Comp Immunol Microbiol Infect Dis 27:297-304 (2004)
DOI:10.1016/j.cimid.2004.03.006
Reference
PMID:18755389
  Authors
Cazorla C, Socolovschi C, Jensenius M, Parola P
  Title
Tick-borne diseases: tick-borne spotted fever rickettsioses in Africa.
  Journal
Infect Dis Clin North Am 22:531-44, ix-x (2008)
DOI:10.1016/j.idc.2008.03.009
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