| Entry |
|
|---|
| Name |
EGFR-overexpression to PI3K signaling pathway
|
|---|
| Definition |
EGFR* -> PI3K -> PIP3 -> AKT -> MTOR -> S6K |
|---|
| Expanded |
1956v4 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475 -> (6198,6199) |
|---|
| Class |
|
|---|
| Type |
Variant
|
|---|
| Pathway |
|
|---|
| Disease |
|
|---|
| Gene |
| 1956 | EGFR; epidermal growth factor receptor |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
| 2475 | MTOR; mechanistic target of rapamycin |
| 6198 | RPS6KB1; ribosomal protein S6 kinase B1 |
| 6199 | RPS6KB2; ribosomal protein S6 kinase B2 |
|
|---|
| Variant |
1956v4 (EGFR*) EGFR overexpression
|
|---|
| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
|---|
| Reference |
|
|---|
| Authors |
Wang D, Xia D, Dubois RN |
|---|
| Title |
The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Bansal K, Liang ML, Rutka JT. |
|---|
| Title |
Molecular biology of human gliomas. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Li X, Wu C, Chen N, Gu H, Yen A, Cao L, Wang E, Wang L |
|---|
| Title |
PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Alanazi IO, Khan Z |
|---|
| Title |
Understanding EGFR Signaling in Breast Cancer and Breast Cancer Stem Cells: Overexpression and Therapeutic Implications. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Mohamed A, Krajewski K, Cakar B, Ma CX |
|---|
| Title |
Targeted therapy for breast cancer. |
|---|
| Journal |
|
|---|
| LinkDB |
|
|---|
