KEGG   NETWORK: N00186
Entry
N00186                      Network                                
Name
IL1-IL1R-p38 signaling pathway
Definition
IL1 -> IL1R -> MYD88 -> IRAK1/4 -> TRAF6 -> TAB1/2/3 -> TAK1 -> MKK3/6 -> MAPK14 -> MK2 -| TTP
  Expanded
(3552,3553) -> (3554+3556) -> 4615 -> (3654,51135) -> 7189 -> (10454,23118,257397) -> 6885 -> (5606,5608) -> 1432 -> 9261 -| 7538
Class
nt06526 MAPK signaling
nt06211 Other MAPK signaling (cancer)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Reference
Pathway
hsa04010  MAPK signaling pathway
Gene
3552  IL1A; interleukin 1 alpha
3553  IL1B; interleukin 1 beta
3554  IL1R1; interleukin 1 receptor type 1
3556  IL1RAP; interleukin 1 receptor accessory protein
4615  MYD88; myeloid differentiation primary response 88
3654  IRAK1; interleukin 1 receptor associated kinase 1
51135  IRAK4; interleukin 1 receptor associated kinase 4
7189  TRAF6; TNF receptor associated factor 6
10454  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1
23118  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2
257397  TAB3; TGF-beta activated kinase 1 and MAP3K7 binding protein 3
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
5606  MAP2K3; mitogen-activated protein kinase kinase 3
5608  MAP2K6; mitogen-activated protein kinase kinase 6
1432  MAPK14; mitogen-activated protein kinase 14
9261  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
7538  ZFP36; ZFP36 ring finger protein
Reference
PMID:28223354
  Authors
Kulawik A, Engesser R, Ehlting C, Raue A, Albrecht U, Hahn B, Lehmann WD, Gaestel M, Klingmuller U, Haussinger D, Timmer J, Bode JG
  Title
IL-1beta-induced and p38MAPK-dependent activation of the mitogen-activated protein kinase-activated protein kinase 2 (MK2) in hepatocytes: Signal transduction with robust and concentration-independent signal amplification.
  Journal
J Biol Chem 292:6291-6302 (2017)
DOI:10.1074/jbc.M117.775023
Reference
PMID:17908789
  Authors
Winzen R, Thakur BK, Dittrich-Breiholz O, Shah M, Redich N, Dhamija S, Kracht M, Holtmann H
  Title
Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets.
  Journal
Mol Cell Biol 27:8388-400 (2007)
DOI:10.1128/MCB.01493-07
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:22048664
  Authors
de Nadal E, Ammerer G, Posas F
  Title
Controlling gene expression in response to stress.
  Journal
Nat Rev Genet 12:833-45 (2011)
DOI:10.1038/nrg3055
Reference
PMID:23602935
  Authors
Thapar R, Denmon AP
  Title
Signaling pathways that control mRNA turnover.
  Journal
Cell Signal 25:1699-710 (2013)
DOI:10.1016/j.cellsig.2013.03.026
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