KEGG   NETWORK: N00188
Entry
N00188                      Network                                
Name
IL1-IL1R-JNK signaling pathway
Definition
IL1 -> IL1R -> MYD88 -> IRAK1/4 -> TRAF6 -> TAB1/2/3 -> TAK1 -> MKK4/7 -> JNK -> AP1
  Expanded
(3552,3553) -> (3554+3556) -> 4615 -> (3654,51135) -> 7189 -> (10454,23118,257397) -> 6885 -> (6416,5609) -> (5599,5601,5602) -> (2353,3725
Class
nt06526 MAPK signaling
nt06211 Other MAPK signaling (cancer)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Reference
Pathway
hsa04010  MAPK signaling pathway
Gene
3552  IL1A; interleukin 1 alpha
3553  IL1B; interleukin 1 beta
3554  IL1R1; interleukin 1 receptor type 1
3556  IL1RAP; interleukin 1 receptor accessory protein
4615  MYD88; myeloid differentiation primary response 88
3654  IRAK1; interleukin 1 receptor associated kinase 1
51135  IRAK4; interleukin 1 receptor associated kinase 4
7189  TRAF6; TNF receptor associated factor 6
10454  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1
23118  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2
257397  TAB3; TGF-beta activated kinase 1 and MAP3K7 binding protein 3
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
6416  MAP2K4; mitogen-activated protein kinase kinase 4
5609  MAP2K7; mitogen-activated protein kinase kinase 7
5599  MAPK8; mitogen-activated protein kinase 8
5601  MAPK9; mitogen-activated protein kinase 9
5602  MAPK10; mitogen-activated protein kinase 10
2353  FOS; Fos proto-oncogene, AP-1 transcription factor subunit
3725  JUN; Jun proto-oncogene, AP-1 transcription factor subunit
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:15125785
  Authors
Sakai A, Han J, Cato AC, Akira S, Li JD
  Title
Glucocorticoids synergize with IL-1beta to induce TLR2 expression via MAP Kinase Phosphatase-1-dependent dual Inhibition of MAPK JNK and p38 in epithelial cells.
  Journal
BMC Mol Biol 5:2 (2004)
DOI:10.1186/1471-2199-5-2
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
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