Entry |
|
Name |
CXCR4-GNAQ-PLCB/G-calcineurin signaling pathway
|
Definition |
CXCL12 -> CXCR4 -> GNAQ -> (PLCB,PLCG) -> IP3 -> Ca2+ -> CALM == CN -> NFAT |
Expanded |
6387 -> 7852 -> 2776 -> (23236,5330,5331,5332,5335,5336) -> C01245 -> C00076 -> (801,805,808) == (5530,5532,5533,5534,5535) -> (4772,4773,4775,4776) |
Class |
nt06161 Human immunodeficiency virus 1 (HIV-1)
nt06167 Human cytomegalovirus (HCMV)
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Type |
Reference
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Pathway |
|
Gene |
6387 | CXCL12; C-X-C motif chemokine ligand 12 |
7852 | CXCR4; C-X-C motif chemokine receptor 4 |
2776 | GNAQ; G protein subunit alpha q |
23236 | PLCB1; phospholipase C beta 1 |
5330 | PLCB2; phospholipase C beta 2 |
5331 | PLCB3; phospholipase C beta 3 |
5332 | PLCB4; phospholipase C beta 4 |
5335 | PLCG1; phospholipase C gamma 1 |
5336 | PLCG2; phospholipase C gamma 2 |
5530 | PPP3CA; protein phosphatase 3 catalytic subunit alpha |
5532 | PPP3CB; protein phosphatase 3 catalytic subunit beta |
5533 | PPP3CC; protein phosphatase 3 catalytic subunit gamma |
5534 | PPP3R1; protein phosphatase 3 regulatory subunit B, alpha |
5535 | PPP3R2; protein phosphatase 3 regulatory subunit B, beta |
4772 | NFATC1; nuclear factor of activated T cells 1 |
4773 | NFATC2; nuclear factor of activated T cells 2 |
4775 | NFATC3; nuclear factor of activated T cells 3 |
4776 | NFATC4; nuclear factor of activated T cells 4 |
|
Metabolite |
C01245 | D-myo-Inositol 1,4,5-trisphosphate |
|
Reference |
|
Authors |
Wu Y, Yoder A |
Title |
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis. |
Journal |
|
Reference |
|
Authors |
Knopf A, Fritsche MK, Li Y |
Title |
CXCR4: A New Player in an Old Scene? |
Journal |
|
Reference |
|
Authors |
Scala S |
Title |
Molecular Pathways: Targeting the CXCR4-CXCL12 Axis--Untapped Potential in the Tumor Microenvironment. |
Journal |
|
Reference |
|
Authors |
Barbieri F, Bajetto A, Florio T |
Title |
Role of chemokine network in the development and progression of ovarian cancer: a potential novel pharmacological target. |
Journal |
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LinkDB |
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