NETWORK: N00444
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Entry
N00444 Network
Name
TNF-p38 signaling pathway
Definition
TNF -> TNFRSF1A -> (RIPK1+TRADD+TRAF2/5) -> (TAK1+TAB1/2) -> MKK3/6 -> MAPK14 -> MSK1/2 -> CREB
Expanded
7124 -> 7132 -> (8737+8717+(7186,
7188)) -> (6885+(10454,
23118)) -> (5606,
5608) -> 1432 -> (8986,
9252) -> (10488,
1385,
1386,
1388,
148327,
468,
64764,
84699,
90993,
9586)
Class
nt06516
TNF signaling
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06180
Pathogenic Escherichia coli
Type
Reference
Pathway
hsa04668
TNF signaling pathway
Gene
7124
TNF; tumor necrosis factor
7132
TNFRSF1A; TNF receptor superfamily member 1A
8737
RIPK1; receptor interacting serine/threonine kinase 1
8717
TRADD; TNFRSF1A associated via death domain
7186
TRAF2; TNF receptor associated factor 2
7188
TRAF5; TNF receptor associated factor 5
6885
MAP3K7; mitogen-activated protein kinase kinase kinase 7
10454
TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1
23118
TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2
5606
MAP2K3; mitogen-activated protein kinase kinase 3
5608
MAP2K6; mitogen-activated protein kinase kinase 6
1432
MAPK14; mitogen-activated protein kinase 14
8986
RPS6KA4; ribosomal protein S6 kinase A4
9252
RPS6KA5; ribosomal protein S6 kinase A5
10488
CREB3; cAMP responsive element binding protein 3
1385
CREB1; cAMP responsive element binding protein 1
1386
ATF2; activating transcription factor 2
1388
ATF6B; activating transcription factor 6 beta
148327
CREB3L4; cAMP responsive element binding protein 3 like 4
468
ATF4; activating transcription factor 4
64764
CREB3L2; cAMP responsive element binding protein 3 like 2
84699
CREB3L3; cAMP responsive element binding protein 3 like 3
90993
CREB3L1; cAMP responsive element binding protein 3 like 1
9586
CREB5; cAMP responsive element binding protein 5
Reference
PMID:
23085193
Authors
Chu WM
Title
Tumor necrosis factor.
Journal
Cancer Lett 328:222-5 (2013)
DOI:
10.1016/j.canlet.2012.10.014
Reference
PMID:
22296764
Authors
Newton K, Dixit VM
Title
Signaling in innate immunity and inflammation.
Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:
10.1101/cshperspect.a006049
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