Entry |
|
Name |
RELN-VLDLR-PI3K signaling pathway
|
Definition |
RELN -> VLDLR == DAB1 -> PI3K -> PIP3 -> AKT -| (TSC1+TSC2) -| RHEB -> MTOR -> S6K |
Expanded |
5649 -> 7436 == 1600 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| (7248+7249) -| 6009 -> 2475 -> (6198,6199) |
Class |
|
Type |
Reference
|
Gene |
7436 | VLDLR; very low density lipoprotein receptor |
1600 | DAB1; DAB adaptor protein 1 |
5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
207 | AKT1; AKT serine/threonine kinase 1 |
208 | AKT2; AKT serine/threonine kinase 2 |
10000 | AKT3; AKT serine/threonine kinase 3 |
7248 | TSC1; TSC complex subunit 1 |
7249 | TSC2; TSC complex subunit 2 |
6009 | RHEB; Ras homolog, mTORC1 binding |
2475 | MTOR; mechanistic target of rapamycin kinase |
6198 | RPS6KB1; ribosomal protein S6 kinase B1 |
6199 | RPS6KB2; ribosomal protein S6 kinase B2 |
|
Metabolite |
C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
Reference |
|
Authors |
Jossin Y, Goffinet AM |
Title |
Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth. |
Journal |
|
Reference |
|
Authors |
Lee GH, D'Arcangelo G |
Title |
New Insights into Reelin-Mediated Signaling Pathways. |
Journal |
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LinkDB |
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