| Entry |
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| Name |
Mutation-caused aberrant SNCA to PERK-ATF4 signaling pathway
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| Definition |
SNCA* -| BIP -| EIF2AK3 -> EIF2S1 -> ATF4 => DDIT3 |
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| Expanded |
6622v1 -| 3309 -| 9451 -> 1965 -> 468 => 1649 |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
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| Gene |
| 6622 | SNCA; synuclein alpha |
| 3309 | HSPA5; heat shock protein family A (Hsp70) member 5 |
| 9451 | EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3 |
| 1965 | EIF2S1; eukaryotic translation initiation factor 2 subunit alpha |
| 468 | ATF4; activating transcription factor 4 |
| 1649 | DDIT3; DNA damage inducible transcript 3 |
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| Variant |
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| Reference |
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| Authors |
Mercado G, Valdes P, Hetz C |
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| Title |
An ERcentric view of Parkinson's disease. |
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| Journal |
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| Reference |
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| Authors |
Mercado G, Castillo V, Soto P, Sidhu A |
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| Title |
ER stress and Parkinson's disease: Pathological inputs that converge into the secretory pathway. |
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| Journal |
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| Reference |
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| Authors |
Tsujii S, Ishisaka M, Hara H |
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| Title |
Modulation of endoplasmic reticulum stress in Parkinson's disease. |
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| Journal |
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| Reference |
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| Authors |
Shah A, Chao J, Legido-Quigley C, Chang RC |
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| Title |
Oxyresveratrol exerts ATF4- and Grp78-mediated neuroprotection against endoplasmic reticulum stress in experimental Parkinson's disease. |
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| Journal |
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| LinkDB |
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