KEGG   NETWORK: N01044
Entry
N01044                      Network                                
Name
MPP+ to electron transfer in Complex I
Definition
MPP+ -| CxI -> Q
  Expanded
C11310 -| (4535+4536+4537+4538+4540+4541+4719+4720+4722+4724+4725+4726+374291+4728+4723+4729+4731+4694+4695+4696+4697+4698+4700+4701+4702+4704+4705+4706+126328+55967+51079+4707+4708+4709+4710+4711+4712+4713+4714+4715+4716+54539+4717+4718) -> C00399
Class
nt06463 Parkinson disease
nt06466 Pathways of neurodegeneration
Type
Env factor
Pathway
hsa05012  Parkinson disease
Disease
H00057  Parkinson disease
Gene
4535  ND1; NADH dehydrogenase, subunit 1 (complex I)
4536  ND2; MTND2
4537  ND3; NADH dehydrogenase, subunit 3 (complex I)
4538  ND4; NADH dehydrogenase, subunit 4 (complex I)
4540  ND5; NADH dehydrogenase, subunit 5 (complex I)
4541  ND6; NADH dehydrogenase, subunit 6 (complex I)
4719  NDUFS1; NADH:ubiquinone oxidoreductase core subunit S1
4720  NDUFS2; NADH:ubiquinone oxidoreductase core subunit S2
4722  NDUFS3; NADH:ubiquinone oxidoreductase core subunit S3
4724  NDUFS4; NADH:ubiquinone oxidoreductase subunit S4
4725  NDUFS5; NADH:ubiquinone oxidoreductase subunit S5
4726  NDUFS6; NADH:ubiquinone oxidoreductase subunit S6
374291  NDUFS7; NADH:ubiquinone oxidoreductase core subunit S7
4728  NDUFS8; NADH:ubiquinone oxidoreductase core subunit S8
4723  NDUFV1; NADH:ubiquinone oxidoreductase core subunit V1
4729  NDUFV2; NADH:ubiquinone oxidoreductase core subunit V2
4731  NDUFV3; NADH:ubiquinone oxidoreductase subunit V3
4694  NDUFA1; NADH:ubiquinone oxidoreductase subunit A1
4695  NDUFA2; NADH:ubiquinone oxidoreductase subunit A2
4696  NDUFA3; NADH:ubiquinone oxidoreductase subunit A3
4697  NDUFA4; NDUFA4 mitochondrial complex associated
4698  NDUFA5; NADH:ubiquinone oxidoreductase subunit A5
4700  NDUFA6; NADH:ubiquinone oxidoreductase subunit A6
4701  NDUFA7; NADH:ubiquinone oxidoreductase subunit A7
4702  NDUFA8; NADH:ubiquinone oxidoreductase subunit A8
4704  NDUFA9; NADH:ubiquinone oxidoreductase subunit A9
4705  NDUFA10; NADH:ubiquinone oxidoreductase subunit A10
4706  NDUFAB1; NADH:ubiquinone oxidoreductase subunit AB1
126328  NDUFA11; NADH:ubiquinone oxidoreductase subunit A11
55967  NDUFA12; NADH:ubiquinone oxidoreductase subunit A12
51079  NDUFA13; NADH:ubiquinone oxidoreductase subunit A13
4707  NDUFB1; NADH:ubiquinone oxidoreductase subunit B1
4708  NDUFB2; NADH:ubiquinone oxidoreductase subunit B2
4709  NDUFB3; NADH:ubiquinone oxidoreductase subunit B3
4710  NDUFB4; NADH:ubiquinone oxidoreductase subunit B4
4711  NDUFB5; NADH:ubiquinone oxidoreductase subunit B5
4712  NDUFB6; NADH:ubiquinone oxidoreductase subunit B6
4713  NDUFB7; NADH:ubiquinone oxidoreductase subunit B7
4714  NDUFB8; NADH:ubiquinone oxidoreductase subunit B8
4715  NDUFB9; NADH:ubiquinone oxidoreductase subunit B9
4716  NDUFB10; NADH:ubiquinone oxidoreductase subunit B10
54539  NDUFB11; NADH:ubiquinone oxidoreductase subunit B11
4717  NDUFC1; NADH:ubiquinone oxidoreductase subunit C1
4718  NDUFC2; NADH:ubiquinone oxidoreductase subunit C2
Perturbant
C11310 (MPP+)  1-Methyl-4-phenylpyridinium
Metabolite
C00399  Ubiquinone
Reference
PMID:25761946
  Authors
Franco-Iborra S, Vila M, Perier C
  Title
The Parkinson Disease Mitochondrial Hypothesis: Where Are We at?
  Journal
Neuroscientist 22:266-77 (2016)
DOI:10.1177/1073858415574600
Reference
PMID:16156740
  Authors
Chu CT, Zhu JH, Cao G, Signore A, Wang S, Chen J
  Title
Apoptosis inducing factor mediates caspase-independent 1-methyl-4-phenylpyridinium toxicity in dopaminergic cells.
  Journal
J Neurochem 94:1685-95 (2005)
DOI:10.1111/j.1471-4159.2005.03329.x
Reference
PMID:27546335
  Authors
Bose A, Beal MF
  Title
Mitochondrial dysfunction in Parkinson's disease.
  Journal
J Neurochem 139 Suppl 1:216-231 (2016)
DOI:10.1111/jnc.13731
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