Entry |
|
Name |
LPA-GNAQ/11-RhoA signaling pathway
|
Definition |
LPA -> LPAR -> (GNAQ,GNA11) -> ARHGEF12 -> RHOA |
Expanded |
C00681 -> (1902,9170,23566,2846,57121) -> (2776,2767) -> 23365 -> 387 |
Class |
|
Type |
Reference
|
Gene |
1902 | LPAR1; lysophosphatidic acid receptor 1 |
9170 | LPAR2; lysophosphatidic acid receptor 2 |
23566 | LPAR3; lysophosphatidic acid receptor 3 |
2846 | LPAR4; lysophosphatidic acid receptor 4 |
57121 | LPAR5; lysophosphatidic acid receptor 5 |
2776 | GNAQ; G protein subunit alpha q |
2767 | GNA11; G protein subunit alpha 11 |
23365 | ARHGEF12; Rho guanine nucleotide exchange factor 12 |
387 | RHOA; ras homolog family member A |
|
Metabolite |
C00681 | 1-Acyl-sn-glycerol 3-phosphate |
|
Reference |
|
Authors |
Vogt S, Grosse R, Schultz G, Offermanns S |
Title |
Receptor-dependent RhoA activation in G12/G13-deficient cells: genetic evidence for an involvement of Gq/G11. |
Journal |
|
Reference |
|
Authors |
Aittaleb M, Boguth CA, Tesmer JJ |
Title |
Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors. |
Journal |
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LinkDB |
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