NETWORK: N01116
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Entry
N01116 Network
Name
Salmonella SseL to TNF-NFKB signaling pathway
Definition
SseL -| NFKBIA
Expanded
K18015 -| 4792
Class
nt06516
TNF signaling
nt06181
Salmonella
Type
Pathogen
Pathway
hsa05132
Salmonella infection
Disease
H00113
Salmonellosis
Gene
4792
NFKBIA; NFKB inhibitor alpha
Perturbant
K18015
(SseL)
elaD; deubiquitinase
Reference
PMID:
18354230
Authors
Le Negrate G, Faustin B, Welsh K, Loeffler M, Krajewska M, Hasegawa P, Mukherjee S, Orth K, Krajewski S, Godzik A, Guiney DG, Reed JC
Title
Salmonella secreted factor L deubiquitinase of Salmonella typhimurium inhibits NF-kappaB, suppresses IkappaBalpha ubiquitination and modulates innate immune responses.
Journal
J Immunol 180:5045-56 (2008)
DOI:
10.4049/jimmunol.180.7.5045
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