KEGG   NETWORK: N01491
Entry
N01491                      Network                                
Name
Lectin pathway of complement cascade, C4/C2 to C3 convertase formation
Definition
[C4,C2] -- ((MBL2,COLEC10/11,FCN)+MASP1/2) -> [C4b,C2a] -> (C4b+C2a)
  Expanded
[(720,721),717] -- ((4153,(10584,78989),(2219,2220,8547))+(5648,10747)) -> [C22542,C22531] -> (C22542+C22531)
Class
nt06513 Complement cascade
nt06171 SARS coronavirus 2 (SARS-CoV-2)
Type
Reference
Pathway
hsa04610  Complement and coagulation cascades
Gene
720  C4A; complement C4A (Rodgers blood group)
721  C4B; complement C4B (Chido blood group)
717  C2; complement C2
4153  MBL2; mannose binding lectin 2
10584  COLEC10; collectin subfamily member 10
78989  COLEC11; collectin subfamily member 11
2219  FCN1; ficolin 1
2220  FCN2; ficolin 2
8547  FCN3; ficolin 3
5648  MASP1; MBL associated serine protease 1
10747  MASP2; MBL associated serine protease 2
Metabolite
C22542  Complement component 4b
C22531  Complement component 2a
Reference
PMID:26082779
  Authors
Merle NS, Church SE, Fremeaux-Bacchi V, Roumenina LT
  Title
Complement System Part I - Molecular Mechanisms of Activation and Regulation.
  Journal
Front Immunol 6:262 (2015)
DOI:10.3389/fimmu.2015.00262
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