KEGG   NETWORK: N01775
Entry
N01775                      Network                                
Name
Inactivation of CaMKII by inducing SERCA2
Definition
MERTK -> ERK => SERCA2 -| CAMK2
  Expanded
10461 -> (5594,5595) => 488 -| (815,816,817,818)
Class
nt06535 Efferocytosis
Type
Reference
Pathway
hsa04148 Efferocytosis   
Gene
10461  MERTK; MER proto-oncogene, tyrosine kinase
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
488  ATP2A2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
815  CAMK2A; calcium/calmodulin dependent protein kinase II alpha
816  CAMK2B; calcium/calmodulin dependent protein kinase II beta
817  CAMK2D; calcium/calmodulin dependent protein kinase II delta
818  CAMK2G; calcium/calmodulin dependent protein kinase II gamma
Reference
  Authors
Cai B, Kasikara C, Doran AC, Ramakrishnan R, Birge RB, Tabas I
  Title
MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity.
  Journal
Sci Signal 11:11/549/eaar3721 (2018)
DOI:10.1126/scisignal.aar3721
Reference
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
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