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Name |
Description |
Object |
Legend |
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hsa05418
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Fluid shear stress and atherosclerosis |
Shear stress represents the frictional force that the flow of blood exerts at the endothelial surfac... |
... 5296 (PIK3R2), 8503 (PIK3R3) 6347 (CCL2) 9817 (KEAP1) 4780 (NFE2L2) 5598 (MAPK7) 4205 (MEF2A), 4208... |
...isturbed blood flow Low & Oscillatory Shear Keap1 Nrf2 ERK5 MEF2 KLF2 Nrf2 NQO1 MKK4/7 MKK3/4/6 ... |
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hsa05225
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Hepatocellular carcinoma |
Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neo... |
...) 4780 (NFE2L2) 4780 (NFE2L2) 7015 (TERT) 9817 (KEAP1) 3162 (HMOX1) 1728 (NQO1) 119391 (GSTO2), 2213... |
..., AXIN, KEAP1, ARID1A, ARID2 E2F Cell cycle DNA c-Myc Survi... |
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hsa05012
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Parkinson disease |
Parkinson disease (PD) is a progressive neurodegenerative movement disorder that results primarily f... |
...1), 9927 (MFN2) 6622 (SNCA) 6531 (SLC6A3) 9817 (KEAP1) 25828 (TXN2), 7295 (TXN) 201266 (SLC39A11), 2... |
...city DNA DNA DNA Mfn1/2 SNCA DOPAL Toxicity DAT Keap1 Trx1 DMT1/ZIP ROS SOD Fenton reaction |
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hsa05200
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Pathways in cancer |
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...), 26508 (HEYL) 2324 (FLT4) 4780 (NFE2L2) 9817 (KEAP1) 3162 (HMOX1) 1728 (NQO1) 119391 (GSTO2), 2213... |
... pathway NRF2 Oxidative or electrophilic stress KEAP1 HO-1 NQO1 GSTs TrxR1 Acro 4HNE O2- HO2 H2O2 GA... |
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hsa05208
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Chemical carcinogenesis - reactive oxygen species |
It is well established that cancer is a multi-step process which involves initiation, promotion and ... |
...45 (AKR1C1), 1646 (AKR1C2), 8644 (AKR1C3) 9817 (KEAP1) 5770 (PTPN1) 1543 (CYP1A1) 1545 (CYP1B1) 1544... |
... (Phase II detoxing enzymes & antioxidants) KEAP1 PTP1B NNK (IARC Group 1) (IARC Group 1) TCDD 1... |
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hsa04120
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Ubiquitin mediated proteolysis |
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions... |
...(RHOBTB2), 55958 (KLHL9), 90293 (KLHL13), 9817 (KEAP1), 9886 (RHOBTB1) 1161 (ERCC8), 1643 (DDB2), 55... |
UBLE1B UBLE1A EloC EloB RBX1 RBX1 RBX1 RBX1 F-box BTB DCAF SOCSbox VHLbox HERC4 HERC3 UBE2W UBE2F UB... |