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Description |
Object |
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hsa05120
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Epithelial cell signaling in Helicobacter pylori infection |
...inds to the tyrosine phosphatase receptor zeta (Ptprz) on epithelial cells and the induced signaling... |
...EGFR) 4067 (LYN), 6714 (SRC) 28964 (GIT1) 5803 (PTPRZ1) 5781 (PTPN11) 10392 (NOD1) |
...ay ZO-1 IL-8R CSK EGFR CagA c-Src/Lyn Git1 UreI Ptprz BabA SHP-2 NOD1 HpaA EPITHELIAL CELL SIGNALI... |
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hsa04726
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Serotonergic synapse |
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in ... |
... 5330 (PLCB2), 5331 (PLCB3), 5332 (PLCB4) 3708 (ITPR1), 3709 (ITPR2), 3710 (ITPR3) 5578 (PRKCA), 557... |
SEROTONERGIC SYNAPSE Glial cell Neuron (Presynaptic terminal) Neuron (Postsynaptic cell) 5-HT 4, 6... |
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hsa04514
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Cell adhesion molecules |
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical... |
...LCAM) 923 (CD6) 6693 (SPN) 6614 (SIGLEC1) 5788 (PTPRC) 933 (CD22) 925 (CD8A), 926 (CD8B), 927 (CD8B2... |
...T cell receptor signaling pathway ALCAM CD6 SPN PTPRC CD22 CD8 ITGB1 ITGA8 ITGB2 ITGAL CD40 CD40 CD4... |
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hsa05017
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Spinocerebellar ataxia |
The autosomal dominant spinocerebellar ataxias (SCAs) are a group of progressive neurodegenerative d... |
...), 2891 (GRIA2), 2892 (GRIA3) 2911 (GRM1) 3708 (ITPR1), 3709 (ITPR2), 3710 (ITPR3) 2259 (FGF14) 6261... |
Parallel fiber PLC PKC DAG AMPAR mGluR1 Glutamate SPINOCEREBELLAR ATAXIA Glutamatergic synapse Purk... |
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hsa04270
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Vascular smooth muscle contraction |
The vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is cont... |
... 5330 (PLCB2), 5331 (PLCB3), 5332 (PLCB4) 3708 (ITPR1), 3709 (ITPR2), 3710 (ITPR3) 163688 (CALML6), ... |
Calcium signaling pathway MLCK MLC MLCP ROCK PKC RhoA RhoGEF VASCULAR SMOOTH MUSCLE CONTRACTION A... |
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hsa04625
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C-type lectin receptor signaling pathway |
C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of ... |
...33 (PPP3CC), 5534 (PPP3R1), 5535 (PPP3R2) 3708 (ITPR1), 3709 (ITPR2), 3710 (ITPR3) 9020 (MAP3K14) 47... |
C-TYPE LECTIN RECEPTOR SIGNALING PATHWAY Dectin-1 Dectin-2 Mincle MCL FcRγ DC-SIGN LSP-1 KSR1 CN... |
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hsa04928
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Parathyroid hormone synthesis, secretion and action |
Parathyroid hormone (PTH) is a key regulator of calcium and phosphorus homeostasis. The principal re... |
...trol) C01330 (Sodium cation) C00698 (Cl-) 3708 (ITPR1), 3709 (ITPR2), 3710 (ITPR3) 23236 (PLCB1), 53... |
PARATHYROID HORMONE SYNTHESIS, SECRETION AND ACTION PLCβ IP3 q/11 Calcium signaling pathway cAM... |
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hsa04935
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Growth hormone synthesis, secretion and action |
Growth hormone (GH) is a peptide hormone secreted from the anterior pituitary and plays a critical r... |
... (Calcium cation) C00165 (Diacylglycerol) 3708 (ITPR1), 3709 (ITPR2), 3710 (ITPR3) 5335 (PLCG1), 533... |
GROWTH HORMONE SYNTHESIS, SECRETION AND ACTION PLCγ IP3 Calcium signaling pathway Somatotroph (... |
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hsa05163
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Human cytomegalovirus infection |
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-her... |
...33 (PPP3CC), 5534 (PPP3R1), 5535 (PPP3R2) 3708 (ITPR1), 3709 (ITPR2), 3710 (ITPR3) 1147 (CHUK), 3551... |
PIP 4EBPs S6K1/2 mTOR Rheb TSC2 TSC1 AKT PI3K HUMAN CYTOMEGALOVIRUS INFECTION EGFR FasL IKK NF κB ... |
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hsa04520
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Adherens junction |
Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important f... |
...CSNK2A2), 1460 (CSNK2B), 283106 (CSNK2A3) 5795 (PTPRJ) 5777 (PTPN6) 5770 (PTPN1) 5792 (PTPRF) 5787 (... |
Smad4 E-Cadherin α-Catenin p120ctn p120ctn E-Cadherin E-Cadherin E-Cadherin TCF/LEF NLK TAK1 CBP Sma... |
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hsa04020
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Calcium signaling pathway |
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is dr... |
...3026 (PLCD3), 5333 (PLCD1), 84812 (PLCD4) 3708 (ITPR1), 3709 (ITPR2), 3710 (ITPR3) 5255 (PHKA1), 525... |
Long term depression Long term potentiation Phosphatidylinositol signaling pathway Apoptosis ... |
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hsa04022
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cGMP-PKG signaling pathway |
Cyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO... |
...(GUCY1A2), 2982 (GUCY1A1), 2983 (GUCY1B1) 3708 (ITPR1), 3709 (ITPR2), 3710 (ITPR3) 10242 (KCNMB2), 1... |
cGMP-PKG SIGNALING PATHWAY MLCP MLC NPR-A cGMP PKG s-GC Sarcoplasmic reticulum (SR) Kca NPR-B Myosi... |
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hsa04070
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Phosphatidylinositol signaling system |
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...808 (CALM3), 810 (CALML3), 91860 (CALML4) 3708 (ITPR1), 3709 (ITPR2), 3710 (ITPR3) 10423 (CDIPT) 529... |
PTEN 2.7.1.158 PI(3,4)P PI(3,5)P PI(5)P PLC PLC 5PP-IP Focal adhesion I(1,3,4)P I(1,3,4,5)P I(4)P I(... |
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hsa04114
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Oocyte meiosis |
During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregatio... |
...6), 996 (CDC27) 991 (CDC20) 89869 (PLCZ1) 3708 (ITPR1), 3709 (ITPR2), 3710 (ITPR3) 163688 (CALML6), ... |
Mos Cdc2 Mad1/2 CycB2/B5 Myt1 Rsk1/2 p42MAPK MEK1 Progesterone OOCYTE MEIOSIS Early translation of ... |
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hsa04210
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Apoptosis |
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by a... |
...) 9451 (EIF2AK3) 1965 (EIF2S1) 468 (ATF4) 3708 (ITPR1), 3709 (ITPR2), 3710 (ITPR3) 5170 (PDPK1) 637 ... |
Mitochondrion p53 signaling pathway TNF signaling pathway Bcl-XL ICAD ATM p53 ENDO-G AIF Bcl-2 IAP/X... |
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hsa04218
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Cellular senescence |
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of f... |
...73 (NFATC2), 4775 (NFATC3), 4776 (NFATC4) 3708 (ITPR1), 3709 (ITPR2), 3710 (ITPR3) 90550 (MCU) 59341... |
CELLULAR SENESCENCE NORE1A PP1A C-Myc HIPK2 ARF MDM2 p53 P53 signaling pathway PI3K AKT TSC1/2 RHEB... |
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hsa04371
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Apelin signaling pathway |
Apelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally d... |
... 5330 (PLCB2), 5331 (PLCB3), 5332 (PLCB4) 3708 (ITPR1), 3709 (ITPR2), 3710 (ITPR3) 6261 (RYR1), 6262... |
APELIN SIGNALING PATHWAY APJ AMPK Sphk1 PAI-1 PI3K Akt MEK1/2 ERK1/2 P70S6K PLCβ IP3 IP3R RyR mTOR... |
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hsa04380
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Osteoclast differentiation |
The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage... |
...885 (SIRPA), 54209 (TREM2), 55423 (SIRPG) 3708 (ITPR1), 3709 (ITPR2), 3710 (ITPR3) 487 (ATP2A1), 488... |
OSTEOCLAST DIFFERENTIATION c-Fms TRAF2/6 RANK RANKL M-CSF OPG CYLD Gab2 NIK IKKα IKKγ IKKα IKKβ IκB... |
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hsa04540
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Gap junction |
Gap junctions contain intercellular channels that allow direct communication between the cytosolic c... |
...), 5331 (PLCB3), 5332 (PLCB4) 1812 (DRD1) 3708 (ITPR1), 3709 (ITPR2), 3710 (ITPR3) |
LPA v-Src cGMP DAG cAMP CK1 PKC Serotonin Glutamate Connexin Connexin Connexin Connexin Connexin Con... |
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hsa04611
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Platelet activation |
Platelets play a key and beneficial role for primary hemostasis on the disruption of the integrity o... |
... G2) C00076 (Calcium cation) C00002 (ATP) 3708 (ITPR1), 3709 (ITPR2), 3710 (ITPR3) 2149 (F2R), 9002 ... |
PLATELET ACTIVATION cAMP DAG Calcium signaling pathway Platelet PAR1/4 P2Y1 ADP TXA2 PLCβ GP VI α2... |