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Name |
Description |
Object |
Legend |
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hsa05200
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Pathways in cancer |
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...ASP9) 572 (BAD) 4193 (MDM2) 1027 (CDKN1B) 598 (BCL2L1) 6774 (STAT3) 6772 (STAT1) 2885 (GRB2) 6654 (S... |
PATHWAYS IN CANCER DCC CASP3 CASP9 CASP3 ECAD β-catenin Wnt α-catenin β-catenin ITGB Dvl ECM ITGA ... |
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hsa04210
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Apoptosis |
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by a... |
... (Sphingosine) C00027 (Hydrogen peroxide) 598 (BCL2L1) 1676 (DFFA) 472 (ATM) 7157 (TP53) 2021 (ENDOG... |
Mitochondrion p53 signaling pathway TNF signaling pathway Bcl-XL ICAD ATM p53 ENDO-G AIF Bcl-2 IAP/X... |
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hsa01521
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EGFR tyrosine kinase inhibitor resistance |
EGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also ser... |
... (JAK1), 3717 (JAK2) 596 (BCL2) 581 (BAX) 598 (BCL2L1) 10018 (BCL2L11) 3479 (IGF1) 7422 (VEGFA) 5154... |
Non-small cell lung cancer Her3 Her2 EGFR Pancreatic cancer mTOR signaling pathway GSK-3 eI... |
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hsa04064
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NF-kappa B signaling pathway |
Nuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that fu... |
...,5-trisphosphate) C00076 (Calcium cation) 598 (BCL2L1) 596 (BCL2) 329 (BIRC2), 330 (BIRC3) 4792 (NFK... |
Cytokine-cytokine receptor interaction Bcl-XL Bcl-2 c-IAP1/2 IκBα IRAK1/4 MyD88 TRAF2/5 RIP1 TRADD I... |
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hsa04151
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PI3K-Akt signaling pathway |
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellul... |
...) 1027 (CDKN1B) 5934 (RBL2) 356 (FASLG) 10018 (BCL2L11) 2309 (FOXO3) 572 (BAD) 4193 (MDM2) 598 (BCL2... |
PIP eIF4E 4EBPs eIF4B S6K1/2 Raptor mTOR GβL Rheb TSC2 TSC1 AKT PDK1 PI3K p53 signaling pathway mTOR... |
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hsa04215
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Apoptosis - multiple species |
Apoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally ... |
...SEPTIN4) 581 (BAX) 578 (BAK1) 596 (BCL2), 598 (BCL2L1) 54205 (CYCS) 54205 (CYCS) 836 (CASP3) 332 (BI... |
APOPTOSIS - MULTIPLE SPECIES Mitochondrion DIAP1 DRONC DRICE GRIM RPR HID dArk Dcp-1 DEBCL RHG fa... |
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hsa04137
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Mitophagy - animal |
Mitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to gro... |
...SNK2B), 283106 (CSNK2A3) 192111 (PGAM5) 23786 (BCL2L13) 23770 (FKBP8) 79594 (MUL1) 25813 (SAMM50) 79... |
...s Foxo3 CITED2 NFκB Hypoxia Src ULK1 CK2 PGAM5 BCL2L13 FKBP8 MUL1 SAMM50 NLRX1 PHB2 MTX1 ER stress P... |
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hsa05145
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Toxoplasmosis |
Toxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite ... |
...12A), 3593 (IL12B) 7124 (TNF) 596 (BCL2), 598 (BCL2L1) 329 (BIRC2), 330 (BIRC3), 331 (XIAP), 79444 (... |
MyD88 IRAK TRAF6 TAK TAB1/2 IKK IκB NFκB ERK JNK p38 MKK3/6 GRA3/5 Toxoplasma gondii tachyzoite Para... |
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hsa05170
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Human immunodeficiency virus 1 infection |
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency... |
...CD3E), 917 (CD3G), 919 (CD247) 596 (BCL2) 598 (BCL2L1) 494551 (WEE2), 7465 (WEE1) 8450 (CUL4B), 8451... |
PIP S6K1/2 mTOR AKT PI3K HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION NF κB NFκB signaling pathway R... |
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hsa05212
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Pancreatic cancer |
Infiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investig... |
...KBKG) 4790 (NFKB1), 5970 (RELA) 572 (BAD) 598 (BCL2L1) 369 (ARAF), 5894 (RAF1), 673 (BRAF) 842 (CASP... |
HER2/neu K-Ras PI3K RacGEF PKB/Akt Rac IKK NFκB Bad Bcl-xl Raf CASP9 MEK ERK RalGDS Ral RalBP1 PLD1 ... |
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hsa05220
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Chronic myeloid leukemia |
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. T... |
...-trisphosphate) 2122 (MECOM), 861 (RUNX1) 598 (BCL2L1) 5781 (PTPN11) 25 (ABL1), 613 (BCR) 7157 (TP53... |
p53 signaling pathway AML-EVI1 Bcl-xl Shp2 BCR-ABL p53 TGF-β signaling pathway Hematopoietic cell li... |
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hsa01524
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Platinum drug resistance |
Platinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid ... |
...113 (BBC3) 355 (FAS) 581 (BAX) 578 (BAK1) 598 (BCL2L1) 27113 (BBC3) 5366 (PMAIP1) 1317 (SLC31A1) 538... |
Mitochondrion p53 signaling pathway ATM p53 Bcl-2 CASP9 CASP3 Bad IAP/XIAP Apaf-1 CytC Bid CASP8 FAD... |
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hsa04014
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Ras signaling pathway |
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating c... |
...5 (ABL1), 27 (ABL2) 9610 (RIN1) 572 (BAD) 598 (BCL2L1) 1147 (CHUK), 3551 (IKBKB), 8517 (IKBKG) 4790 ... |
MAPK signaling pathway RAS SIGNALING PATHWAY ERK MEK Raf-1 Ras PI3K-Akt signaling pathway Grb2 SOS... |
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hsa04068
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FoxO signaling pathway |
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellu... |
...7 (GADD45A), 4616 (GADD45B) 356 (FASLG) 10018 (BCL2L11) 8743 (TNFSF10) 604 (BCL6) 847 (CAT) 6648 (SO... |
IKKα/β JNK ERK1/2 AMPK INS Glucose FOXO SOS Ras MEK1/2 INSR Raf PEPCK G6PC Akt P13K PDK1/2 IRS PIP F... |
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hsa04115
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p53 signaling pathway |
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and ... |
...5366 (PMAIP1) 92344 (GORAB) 10572 (SIVA1) 598 (BCL2L1) 596 (BCL2) 84883 (AIFM2) 25946 (ZNF385A) 1084... |
Siah-1 IGF-BP3 Gadd45 MDM-X CHK1 ATR CHK2 ATM Reprimo 14-3-3-σ CDK2 Cyclin E Cell cycle Apoptosis TS... |
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hsa04140
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Autophagy - animal |
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, orga... |
...6) 55626 (AMBRA1) 3708 (ITPR1) 596 (BCL2) 598 (BCL2L1) 285973 (ATG9B), 79065 (ATG9A) 100130302 (SUPT... |
PI3P AUTOPHAGY - ANIMAL Nutrient starvation (Amino acids, glucose) mTORC1 complex ER stress ROS Lo... |
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hsa04621
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NOD-like receptor signaling pathway |
Specific families of pattern recognition receptors are responsible for detecting various pathogens a... |
...CASP5) 841 (CASP8) 8772 (FADD) 596 (BCL2) 598 (BCL2L1) 55669 (MFN1), 9927 (MFN2) 3428 (IFI16) 29108 ... |
ASC pro-CASP1 ASC pro-CASP1 ASC pro-CASP1 ASC pro-CASP1 NOD1 NOD2 iE-DAP RIP2 IKKα/β TAK1 TAB NLRP1 ... |
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hsa04630
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JAK-STAT signaling pathway |
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a h... |
...), 894 (CCND2), 896 (CCND3) 1026 (CDKN1A) 598 (BCL2L1) 316 (AOX1) 2670 (GFAP) 1387 (CREBBP), 2033 (E... |
JAK-STAT SIGNALING PATHWAY STAT JAK1/3 Receptor STAT IL2 family STAT JAK2 Receptor STAT Hormone ST... |
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hsa04932
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Non-alcoholic fatty liver disease |
Non-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to mor... |
... 355 (FAS) 9451 (EIF2AK3) 1965 (EIF2S1) 10018 (BCL2L11) 468 (ATF4) 1649 (DDIT3) 1571 (CYP2E1) 7040 (... |
NON-ALCOHOLIC FATTY LIVER DISEASE Simple steatosis (without inflammation and fibrosis) (Cirrhos... |
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hsa05012
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Parkinson disease |
Parkinson disease (PD) is a progressive neurodegenerative movement disorder that results primarily f... |
...PRKN) 581 (BAX) 6622 (SNCA) 11315 (PARK7) 598 (BCL2L1) 10131 (TRAP1) 65018 (PINK1) 7157 (TP53) 1616 ... |
LRRK2 Ubiquitin mediated proteolysis Proteasome Apoptosis UBA1 UbcH7/8 Parkin CDCrel1 synphilin1 Pae... |