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Name |
Description |
Object |
Legend |
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hsa05213
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Endometrial cancer |
Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common mali... |
...45A), 4616 (GADD45B) 581 (BAX) 578 (BAK1) 1643 (DDB2) 51426 (POLK) 7157 (TP53) 1026 (CDKN1A) 10912 (... |
β-Catenin β-Catenin Ras APC Axin GSK-3β α-Catenin β-Catenin Cell cycle Fkhrl1 BAD Casp9 ILK ErbB sig... |
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hsa05226
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Gastric cancer |
Gastric cancer (GC) is one of the world's most common cancers. According to Lauren's histological cl... |
...45A), 4616 (GADD45B) 581 (BAX) 578 (BAK1) 1643 (DDB2) 51426 (POLK) 7040 (TGFB1), 7042 (TGFB2), 7043 ... |
GASTRIC CANCER Ras Raf MEK ERK1/2 Shc Grb2 SOS mTOR S6K PI3K-Akt signaling pathway Ras Raf MEK ERK1... |
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hsa03420
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Nucleotide excision repair |
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by c... |
...2H2C), 730394 (GTF2H2C_2) 404672 (GTF2H5) 1643 (DDB2) 1642 (DDB1) 8450 (CUL4B), 8451 (CUL4A) 9978 (R... |
...lδ RPA TFIIH4 ERCC1 XPA TFIIH3 TFIIH2 TTDA UVRB DDB2 DDB1 Cul4 RBX1 MFD Ubiquitin mediated proteolys... |
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hsa05161
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Hepatitis B |
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circu... |
... 4615 (MYD88) 1387 (CREBBP), 2033 (EP300) 1643 (DDB2) 4615 (MYD88) 5594 (MAPK1), 5595 (MAPK3) 1147 (... |
...mage HCC invasion and metastasis Bcl2 MyD88 CBP DDB2 Relief of HBx stability and viral replication N... |
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hsa04115
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p53 signaling pathway |
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and ... |
...) 64326 (COP1) 50484 (RRM2B), 6241 (RRM2) 1643 (DDB2) 55240 (STEAP3) 5728 (PTEN) 5268 (SERPINB5) 373... |
Siah-1 IGF-BP3 Gadd45 MDM-X CHK1 ATR CHK2 ATM Reprimo 14-3-3-σ CDK2 Cyclin E Cell cycle Apoptosis TS... |
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hsa04120
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Ubiquitin mediated proteolysis |
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions... |
...817 (KEAP1), 9886 (RHOBTB1) 1161 (ERCC8), 1643 (DDB2), 55070 (DET1), 64326 (COP1) 8651 (SOCS1), 9021... |
UBLE1B UBLE1A EloC EloB RBX1 RBX1 RBX1 RBX1 F-box BTB DCAF SOCSbox VHLbox HERC4 HERC3 UBE2W UBE2F UB... |
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hsa05169
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Epstein-Barr virus infection |
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly... |
...45A), 4616 (GADD45B) 581 (BAX) 578 (BAK1) 1643 (DDB2) 51426 (POLK) 1026 (CDKN1A) 1017 (CDK2) 890 (CC... |
gp350 gH/gL gp42 CD21 MHC-II EBNA2 EPSTEIN-BARR VIRUS INFECTION B cell RBP-Jκ SKIP SMRT EBNA3C Vir... |
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hsa05200
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Pathways in cancer |
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...45A), 4616 (GADD45B) 581 (BAX) 578 (BAK1) 1643 (DDB2) 51426 (POLK) 7015 (TERT) 7012 (TERC) 2099 (ESR... |
PATHWAYS IN CANCER DCC CASP3 CASP9 CASP3 ECAD β-catenin Wnt α-catenin β-catenin ITGB Dvl ECM ITGA ... |
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hsa05202
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Transcriptional misregulation in cancer |
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged ... |
...45A), 4616 (GADD45B) 581 (BAX) 578 (BAK1) 1643 (DDB2) 51426 (POLK) 894 (CCND2) 4286 (MITF) |
TRANSCRIPTIONAL MISREGULATION IN CANCER Ewing's sarcoma Clear-cell sarcoma Desmoplastic small ro... |
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hsa05210
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Colorectal cancer |
Colorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. C... |
...45A), 4616 (GADD45B) 581 (BAX) 578 (BAK1) 1643 (DDB2) 51426 (POLK) 5366 (PMAIP1) 572 (BAD) 10018 (BC... |
DCC CASP3 TGFβ PI3K CASP9 APPL CASP3 APC Smad2 TGFβRI Smad4 hMLH1 hMSH2 K-Ras Raf JNK Axin Axin RalG... |
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hsa05212
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Pancreatic cancer |
Infiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investig... |
...45A), 4616 (GADD45B) 581 (BAX) 578 (BAK1) 1643 (DDB2) 51426 (POLK) |
HER2/neu K-Ras PI3K RacGEF PKB/Akt Rac IKK NFκB Bad Bcl-xl Raf CASP9 MEK ERK RalGDS Ral RalBP1 PLD1 ... |
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hsa05214
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Glioma |
Gliomas are the most common of the primary brain tumors and account for more than 40% of all central... |
...45A), 4616 (GADD45B) 581 (BAX) 578 (BAK1) 1643 (DDB2) 51426 (POLK) |
EGF TGFα PDGF IGF-1 EGFR PDGFR IGFR EGF TGFα PDGF IGF-1 EGFR PDGFR IGFR CAM CAMK PKC Shc Grb2 Sos Ra... |
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hsa05216
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Thyroid cancer |
Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine ca... |
...45A), 4616 (GADD45B) 581 (BAX) 578 (BAK1) 1643 (DDB2) 51426 (POLK) |
Ras PPARγ BRAF BRAF ERK MEK PPFP RXR β-catenin c-Myc ECAD THYROID CANCER ERK CyclinD1 MEK BRAF Ras ... |
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hsa05217
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Basal cell carcinoma |
Cancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account f... |
...45A), 4616 (GADD45B) 581 (BAX) 578 (BAK1) 1643 (DDB2) 51426 (POLK) |
KIF7 Cholesterol GLI1 PTCH1 BMP Wnt SHH APC PTCH1 SUFU Axin Dvl Frizzled BASAL CELL CARCINOMA GLI S... |
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hsa05218
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Melanoma |
Melanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western popu... |
...45A), 4616 (GADD45B) 581 (BAX) 578 (BAK1) 1643 (DDB2) 51426 (POLK) |
p53 signaling pathway Melanogenesis BRAF ECAD Adherens junction NRAS CDK4 CyclinD1 MITF PTEN RTK Bad... |
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hsa05220
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Chronic myeloid leukemia |
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. T... |
...45A), 4616 (GADD45B) 581 (BAX) 578 (BAK1) 1643 (DDB2) 51426 (POLK) |
p53 signaling pathway AML-EVI1 Bcl-xl Shp2 BCR-ABL p53 TGF-β signaling pathway Hematopoietic cell li... |
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hsa05222
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Small cell lung cancer |
Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Smal... |
...45A), 4616 (GADD45B) 581 (BAX) 578 (BAK1) 1643 (DDB2) 51426 (POLK) |
p53 signaling pathway CyclinE CDK2 CyclinD1 Apoptosis ECM-receptor interaction Focal adhesion ITGB I... |
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hsa05223
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Non-small cell lung cancer |
Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-... |
...45A), 4616 (GADD45B) 581 (BAX) 578 (BAK1) 1643 (DDB2) 51426 (POLK) 4233 (MET) 3082 (HGF) 3798 (KIF5A... |
PKC Retinoic acid DAG PIP Forkhead CASP9 BAD PKB/Akt PDK1 PI3K CDK4/6 CyclinD1 E2F Ras PLCγ TGFα EGF... |
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hsa05224
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Breast cancer |
Breast cancer is the leading cause of cancer death among women worldwide. The vast majority of breas... |
...45A), 4616 (GADD45B) 581 (BAX) 578 (BAK1) 1643 (DDB2) 51426 (POLK) |
BREAST CANCER EGFR CoR Ras Raf MEK ERK1/2 Shc Grb2 SOS Estrogen signaling pathway Jagged Notch mTOR... |
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hsa05225
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Hepatocellular carcinoma |
Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neo... |
...45A), 4616 (GADD45B) 581 (BAX) 578 (BAK1) 1643 (DDB2) 51426 (POLK) 7039 (TGFA) 5335 (PLCG1), 5336 (P... |
HEPATOCELLULAR CARCINOMA EGFR Ras Raf MEK ERK1/2 Shc Grb2 SOS mTOR S6K IGF-II IGF1R PI3K-Akt signal... |