| Entry |
Thumbnail Image |
Name |
Description |
Object |
Legend |
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hsa03440
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Homologous recombination |
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs... |
7156 (TOP3A), 8940 (TOP3B) 641 (BLM) 7979 (SEM1) 5893 (RAD52) 4361 (MRE11) 10111 (RAD50) 7517 (XRCC3... |
... PriA DpoI Rad57 Mus81 RecA RecR HOMOLOGOUS RECOMBINATION Mre11 Rad50 Rad51B Nbs1 RPA Rad51 DpoIII ... |
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hsa03083
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Polycomb repressive complex |
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...T) 3054 (HCFC1) 404281 (YY2), 7528 (YY1) 114785 (MBD6), 55777 (MBD5) 221937 (FOXK1), 3607 (FOXK2) 60... |
POLYCOMB REPRESSIVE COMPLEX Crosstalk between cPRC1 and PRC2 PRC2 Crosstalk between ncPRC1 and PRC2... |
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hsa04744
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Phototransduction |
...e pigments, the rhodopsins, which consist of a membrane embedded chromophore, 11-cis-retinal, and a ... |
C00076 (Calcium cation) C01330 (Sodium cation) C00942 (3',5'-Cyclic GMP) C00144 (GMP) C00942 (3',5'-... |
PHOTOTRANSDUCTION DARK LIGHT Disc membrane Disc membrane CNG CNG Hyperpolarization (Light response)... |
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hsa04144
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Endocytosis |
...cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surf... |
... 10254 (STAM2), 8027 (STAM) 9146 (HGS) 10617 (STAMBP) 9101 (USP8) 1759 (DNM1), 1785 (DNM2), 26052 (D... |
...sis CHMP5 CDC42 aPKC PAR6 PAR3 uncoating disassembly of ESCRTs ARF6 Ras Src ATP ADP Rab11 PI(3,4,5)... |
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hsa04330
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Notch signaling pathway |
...llular signaling mechanism essential for proper embryonic development in all metazoan organisms in t... |
...1840 (DTX1), 196403 (DTX3), 23220 (DTX4) 8650 (NUMB), 9253 (NUMBL) 182 (JAG1), 3714 (JAG2) 4851 (NOT... |
...α Hes1/5 CSL SKIP HATs MAML ADAM17 PSE2 Deltex Numb Serrate Notch Dvl NOTCH SIGNALING PATHWAY Frin... |
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hsa02010
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ABC transporters |
...ts of three components; typically two integral membrane proteins each having six transmembrane segme... |
C16421 (AI-2) C01684 (D-Rhamnose) C00095 (D-Fructose) C01487 (D-Allose) C00181 (D-Xylose) C03619 (Me... |
...en KpsT KpsE Heme Capsular polysaccharide CcmA CcmB CcmC Cellar division involvment CylB CylA Hemoly... |
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hsa05110
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Vibrio cholerae infection |
... the entire CTX complex is carried from plasma membrane (PM) to endoplasmic reticulum (ER). In the E... |
C00014 (Ammonia) C00080 (H+) C00238 (Potassium cation) C00238 (Potassium cation) C01330 (Sodium cati... |
...rt Water and electrolyte secretion Vasolateral membrane Vacuolation Hemolysis Ca -dependent Cl /H... |
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hsa03008
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Ribosome biogenesis in eukaryotes |
...ogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins.... |
100008588 (RNA18SN5), 106631781 (RNA18SN1), 109864271 (RNA45SN4), 109864273 (RNA18SN4), 109864280 (R... |
RIBOSOME BIOGENESIS IN EUKARYOTES Pol I Pol III Nucleolus UTP-B complex 18S 5.8S 25S U3 complex... |
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hsa04350
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TGF-beta signaling pathway |
...nsforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone m... |
... 4090 (SMAD5), 4093 (SMAD9) 8646 (CHRD) 25805 (BAMBI) 25805 (BAMBI) 25805 (BAMBI) 60436 (TGIF2), 705... |
...esoderm specification G1 arrest Gonadal growth, embryo differentiation, placenta formation, etc Left... |
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hsa04610
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Complement and coagulation cascades |
...se conversions, culminating the formation of thrombin, the enzyme responsible for the conversion of ... |
...IIIa) C01065 (Coagulation factor Xa) C00752 (Thrombin) C03780 (Coagulation factor Va) C00290 (Fibrin... |
... F12a F12 F11 F11a F9a VWF F8a F10a F10 F2a (Thrombin) F5a Fibrin monomer Fibrinogen Fibrin degrada... |
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hsa04210
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Apoptosis |
...he 'extrinsic' pathway involves stimulation of members of the tumor necrosis factor (TNF) receptor s... |
... 835 (CASP2) 55367 (PIDD1) 55367 (PIDD1) 3002 (GZMB) 5551 (PRF1) 60 (ACTB), 71 (ACTG1) 10376 (TUBA1B... |
.../2 Bax Bak Bax/Bak-induced mitochondrial outer membrane permeabilization (MOMP) Bcl-XL DAXX ASK1 JNK... |
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hsa04915
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Estrogen signaling pathway |
... as "nuclear-initiated steroid signaling" and "membrane-initiated steroid signaling". In the "nuclea... |
C00951 (Estradiol-17beta) C00951 (Estradiol-17beta) C00951 (Estradiol-17beta) C00575 (3',5'-Cyclic A... |
...PI3K Akt (Cardiomyocyte, neuron) Cell survival Membrane-initiated steroid signaling Membrane-initiat... |
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hsa03060
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Protein export |
...y synthesized proteins into or across the cell membrane. The translocation channel is formed from a ... |
5018 (OXA1L) 6727 (SRP14) 6731 (SRP72) 6730 (SRP68) 6729 (SRP54) 6728 (SRP19) 6734 (SRPRA) 6726 (SRP... |
...ing complex GET3 GET4 GET5 BAG6 SGTA GET1 GET2 Membrane receptor SND2 SND3 SND1 SND (SRP-independent... |
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hsa04962
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Vasopressin-regulated water reabsorption |
...AQP2) vesicle insertion into the apical plasma membrane. This results in higher water permeability i... |
C00575 (3',5'-Cyclic AMP) C00001 (H2O) C00001 (H2O) C00001 (H2O) C00001 (H2O) 551 (AVP) 554 (AVPR2) ... |
...4 VAMP2 NSF Dynactin Dynein Microtubule Apical membrane Basolateral membrane Water homeostasis |
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hsa04973
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Carbohydrate digestion and absorption |
...te by SGLT1 located in the apical brush border membrane and then exit through the basolateral membra... |
C00092 (D-Glucose 6-phosphate) C00092 (D-Glucose 6-phosphate) C00031 (D-Glucose) C00031 (D-Glucose) ... |
...ion Amylase GLUT2 Glucose Ca 1.3 Brush border-membrane Basolateral membrane GLUT2 Dietary carbohydr... |
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hsa05031
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Amphetamine addiction |
...r concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefrontal cortex (mPFC), pr... |
C00082 (L-Tyrosine) C00355 (3,4-Dihydroxy-L-phenylalanine) C03758 (Dopamine) C03758 (Dopamine) C0375... |
...ph Amph Ventral tegmental area (VTA) Nucleus accumbens (NAc) Depolarization PDYN arc c-fos ΔFosB Ind... |
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hsa00510
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N-Glycan biosynthesis |
...ycans begins on the cytoplasmic face of the ER membrane with the transferase reaction of UDP-GlcNAc ... |
G10596 G00022 G00021 G00020 G00019 G00018 (DS 3) G00017 G00016 G00015 G00014 G00013 G00012 G00011 G0... |
ALG14 DPM3 DPM2 Various types of N-glycan biosynthesis ALG6 ALG12 ALG9 ALG3 N-glycan degradation MGA... |
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hsa00563
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Glycosylphosphatidylinositol (GPI)-anchor biosynthesis |
...l surface proteins can be attached to the cell membrane via the glycolipid structure called glycosyl... |
G13150 G12396 (6-(alpha-D-glucosaminyl)-1D-myo-inositol) G00145 G00143 G00144 G00146 G13151 G13128 C... |
PIG-Y DPM2 PIG-Q PIG-P PIG-H PIG-C PIG-X PIG-U PIG-T PIG-S 6-(α-D-Glucosaminyl)-1D-myo-inositol PIG-... |
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hsa04072
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Phospholipase D signaling pathway |
...d in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, ... |
C05981 (Phosphatidylinositol-3,4,5-trisphosphate) C00165 (Diacylglycerol) C01245 (D-myo-Inositol 1,4... |
MAPK signaling pathway PHOSPHOLIPASE D SIGNALING PATHWAY ERK MEK Raf-1 Ras PI3K-Akt signaling pat... |
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hsa04512
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ECM-receptor interaction |
...between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also... |
...G10505 (Hyaluronic acid) 10319 (LAMC3), 22798 (LAMB4), 284217 (LAMA1), 3908 (LAMA2), 3909 (LAMA3), 3... |
...proteins Cytoadhesin Leukocytes proteins Other combination Glycoprotein Ig-SF FREM1/2 FRAS1 DPP DSP ... |