| Entry |
Thumbnail Image |
Name |
Description |
Object |
Legend |
|
hsa04217
|
|
Necroptosis |
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumo... |
...747 (GLUD2) 291 (SLC25A4), 292 (SLC25A5), 293 (SLC25A6), 83447 (SLC25A31) 6609 (SMPD1) 192111 (PGAM5... |
NECROPTOSIS TNF TNFR1 TRADD TRAF2/5 MLKL TLR4 IFNR LPS IFN JAKs TRAILR TRAIL Fas FasL IAPs Casp8 cFL... |
|
hsa04020
|
|
Calcium signaling pathway |
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is dr... |
...134 (TNNC1) 291 (SLC25A4), 292 (SLC25A5), 293 (SLC25A6), 83447 (SLC25A31) 90550 (MCU) 107 (ADCY1), 1... |
Long term depression Long term potentiation Phosphatidylinositol signaling pathway Apoptosis ... |
|
hsa04022
|
|
cGMP-PKG signaling pathway |
Cyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO... |
...105 (PPIF), 291 (SLC25A4), 292 (SLC25A5), 293 (SLC25A6), 7416 (VDAC1), 7417 (VDAC2), 7419 (VDAC3), 8... |
cGMP-PKG SIGNALING PATHWAY MLCP MLC NPR-A cGMP PKG s-GC Sarcoplasmic reticulum (SR) Kca NPR-B Myosi... |
|
hsa04218
|
|
Cellular senescence |
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of f... |
...896 (CCND3) 291 (SLC25A4), 292 (SLC25A5), 293 (SLC25A6), 83447 (SLC25A31) 7416 (VDAC1), 7417 (VDAC2)... |
CELLULAR SENESCENCE NORE1A PP1A C-Myc HIPK2 ARF MDM2 p53 P53 signaling pathway PI3K AKT TSC1/2 RHEB... |
|
hsa04613
|
|
Neutrophil extracellular trap formation |
Neutrophils play a central role in innate immune defense. One of the mechanisms of neutrophil action... |
...105 (PPIF), 291 (SLC25A4), 292 (SLC25A5), 293 (SLC25A6), 7416 (VDAC1), 7417 (VDAC2), 7419 (VDAC3), 8... |
Neutrophil FcγRIIA FcγRI Src Syk IgG PI3K PIP PLC DAG PKC Raf1 MEK ERK1/2 Akt NOD-like receptor sign... |
|
hsa05010
|
|
Alzheimer disease |
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cogniti... |
...105 (PPIF), 291 (SLC25A4), 292 (SLC25A5), 293 (SLC25A6), 7416 (VDAC1), 7417 (VDAC2), 7419 (VDAC3), 8... |
PEN2 PSEN NCSTN APH-1 γ-Secretase BACE ADAM10/17 β-Secretase α-Secretase TNF Microglia AICD C99 sAPP... |
|
hsa05012
|
|
Parkinson disease |
Parkinson disease (PD) is a progressive neurodegenerative movement disorder that results primarily f... |
...105 (PPIF), 291 (SLC25A4), 292 (SLC25A5), 293 (SLC25A6), 7416 (VDAC1), 7417 (VDAC2), 7419 (VDAC3), 8... |
LRRK2 Ubiquitin mediated proteolysis Proteasome Apoptosis UBA1 UbcH7/8 Parkin CDCrel1 synphilin1 Pae... |
|
hsa05016
|
|
Huntington disease |
Huntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects m... |
...105 (PPIF), 291 (SLC25A4), 292 (SLC25A5), 293 (SLC25A6), 7416 (VDAC1), 7417 (VDAC2), 7419 (VDAC3), 8... |
HUNTINGTON DISEASE Cx I Cx II Cx III Cx IV Cx V Htt Htt Htt Htt Htt REST REST coREST Sin3A HDACs DN... |
|
hsa05017
|
|
Spinocerebellar ataxia |
The autosomal dominant spinocerebellar ataxias (SCAs) are a group of progressive neurodegenerative d... |
...105 (PPIF), 291 (SLC25A4), 292 (SLC25A5), 293 (SLC25A6), 7416 (VDAC1), 7417 (VDAC2), 7419 (VDAC3), 8... |
Parallel fiber PLC PKC DAG AMPAR mGluR1 Glutamate SPINOCEREBELLAR ATAXIA Glutamatergic synapse Purk... |
|
hsa05020
|
|
Prion disease |
Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal n... |
...105 (PPIF), 291 (SLC25A4), 292 (SLC25A5), 293 (SLC25A6), 7416 (VDAC1), 7417 (VDAC2), 7419 (VDAC3), 8... |
PrP PRION DISEASE DNA Endoplasmic reticulum (ER) Neuron Endocytosis Proteasome Golgi Early endosome... |
|
hsa05022
|
|
Pathways of neurodegeneration - multiple diseases |
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affec... |
...105 (PPIF), 291 (SLC25A4), 292 (SLC25A5), 293 (SLC25A6), 7416 (VDAC1), 7417 (VDAC2), 7419 (VDAC3), 8... |
PATHWAYS OF NEURODEGENERATION - MULTIPLE DISEASES Endoplasmic reticulum (ER) PrP ER stress CASP... |
|
hsa05164
|
|
Influenza A |
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus... |
...(TNFRSF10A) 291 (SLC25A4), 292 (SLC25A5), 293 (SLC25A6), 83447 (SLC25A31) 7416 (VDAC1) 23633 (KPNA6)... |
INFLUENZA A Alveolar and bronchial epithelial cells Alveolar macrophages Type II pneumocytes Endoso... |
|
hsa05166
|
|
Human T-cell leukemia virus 1 infection |
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult... |
...4893 (NRAS) 291 (SLC25A4), 292 (SLC25A5), 293 (SLC25A6), 706 (TSPO), 7416 (VDAC1), 7417 (VDAC2), 741... |
HUMAN T-CELL LEUKEMIA VIRUS 1 INFECTION Human T-lymphotropic virus-I gp21 gp46 NRP1 CD4+ T cell... |
|
hsa05208
|
|
Chemical carcinogenesis - reactive oxygen species |
It is well established that cancer is a multi-step process which involves initiation, promotion and ... |
...105 (PPIF), 291 (SLC25A4), 292 (SLC25A5), 293 (SLC25A6), 7416 (VDAC1), 7417 (VDAC2), 7419 (VDAC3), 8... |
CHEMICAL CARCINOGENESIS - REACTIVE OXYGEN SPECIES CYP1A2 4-Aminobiphenyl N-Hydroxy-4-aminobiphe... |
|
hsa05415
|
|
Diabetic cardiomyopathy |
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients ... |
...105 (PPIF), 291 (SLC25A4), 292 (SLC25A5), 293 (SLC25A6), 7416 (VDAC1), 7417 (VDAC2), 7419 (VDAC3), 8... |
FFA FFA LCFA-CoA DAG PKCα/δ FAT/CD36 Cer PP2A DIABETIC CARDIOMYOPATHY PKCβ Glucose Glucose UDP-GlcNA... |