ERK signaling |
N00021 |
|
EGF | → | (ERBB2+EGFR) | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
N00252 |
|
EGF | → | (ERBB2*+EGFR) | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
N00019 |
|
FGF | → | FGFR | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
N00020 |
|
| | FGFR* | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
N00216 |
|
HGF | → | MET | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
N00259 |
|
| | MET* | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
N00012 |
|
| | | | | | | | (KRAS*,NRAS*) | → | RAF | → | MEK | → | ERK | → | CCND1 |
| | |
PI3K signaling |
N00284 |
|
| | AREG | → | EGFR | → | PI3K | → | PIP3 | → | AKT | → | MTOR | → | S6K |
N00253 |
|
| | EGF | → | (ERBB2*+EGFR) | → | PI3K | → | PIP3 | → | AKT | → | MTOR | → | S6K |
N00037 |
|
| | FGF | → | FGFR | → | PI3K | → | PIP3 | → | AKT | → | MTOR | → | S6K |
N00038 |
|
| | | | FGFR* | → | PI3K | → | PIP3 | → | AKT | → | MTOR |
N00043 |
|
HGF | → | MET | → | GAB1 | → | PI3K | → | PIP3 | → | AKT | ⊣ | BAD |
N00260 |
|
| | MET* | → | GAB1 | → | PI3K | → | PIP3 | → | AKT | → | MTOR |
| | |
WNT signaling |
N00056 |
|
WNT | → | (FZD+LRP5/6) | → | (DVL+FRAT) | ⊣ | (GSK3B+AXIN+APC) | ⊣ | CTNNB1 | → | TCF/LEF | ⇒ | (MYC,CCND1) |
N00057 |
|
| | | | (GSK3B+AXIN) | ⌿ | APC* | ⌿ | CTNNB1 | → | TCF/LEF | ⇒ | (BIRC5,MYC,CCND1) |
N00257 |
|
| | | | | | CDH1* | ⌿ | CTNNB1 | → | TCF/LEF | ⇒ | (MYC,CCND1) |
N00258 |
|
| | | | | | CDH1* | ⌿ | CTNNB1 | → | TCF/LEF | ⇒ | (MYC,CCND1) |
| | |
TGFB signaling |
N00063 |
|
TGFB | → | (TGFBR2+TGFBR1) | → | (SMAD2,SMAD3) | = | SMAD4 |
N00256 |
|
| | (TGFBR2+TGFBR1*) | ⌿ | (SMAD2,SMAD3) |
| | |
Cell cycle |
N00091 |
|
(SCF+SKP2) | ⊣ | CDKN1B | ⊣ | ((CCNA,CCNE)+CDK2) | → | RB1 | ⌿ | E2F |
N00254 |
|
| | CDKN1B* | ⌿ | (CCNE+CDK2) | → | RB1 | ⌿ | E2F |
N00255 |
|
| | | | (CCNE*+CDK2) | → | RB1 | ⌿ | E2F |
| | |
Telomerase activity |
N00239 |
|
TERC | ⌿ | DNA |
N00240 |
|
(TERT*+TERC) | → | DNA |
| | |
Transcription |
N00115 |
|
TP53* | ⌿ | (CDKN1A,GADD45,BAX.. |
N00250 |
|
CDX2* | ⇒ | (MUC2,CDH17,REG4,A.. |
N00251 |
|
CDX2* | ⫤ | SHH |
|