| | NETWORK: N00021 | |
Entry |
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Name |
EGF-ERBB2-RAS-ERK signaling pathway
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Definition |
EGF -> (ERBB2+EGFR) -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK |
Expanded |
1950 -> (2064+1956) -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) |
Class |
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Type |
Reference
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Pathway |
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Gene |
1950 | EGF; epidermal growth factor |
2064 | ERBB2; erb-b2 receptor tyrosine kinase 2 |
1956 | EGFR; epidermal growth factor receptor |
2885 | GRB2; growth factor receptor bound protein 2 |
6654 | SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 |
6655 | SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 |
3265 | HRAS; HRas proto-oncogene, GTPase |
3845 | KRAS; KRAS proto-oncogene, GTPase |
4893 | NRAS; NRAS proto-oncogene, GTPase |
369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
5594 | MAPK1; mitogen-activated protein kinase 1 |
5595 | MAPK3; mitogen-activated protein kinase 3 |
|
Reference |
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Authors |
Molina JR, Adjei AA |
Title |
The Ras/Raf/MAPK pathway. |
Journal |
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LinkDB |
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