Network variation - Glioma
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ENTRY
nt06273
Name
Glioma
Category
Disease view; Cancer
Pathway
hsa05214
Glioma
Disease
H00042
Glioma
Display
drug-target relation
disease type
ERK signaling
D1
|
N00001
EGF
→
EGFR
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
→
CCND1
D1
|
N00513
EGFR*
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
→
CCND1
D1
|
N00006
EGFR*
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
D1
|
N00041
EGFR*
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
D1
|
N00015
PDGF
→
PDGFR
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
D1
|
N00016
PDGF*
→
PDGFR
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
D1
|
N00018
PDGFR*
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
PI3K signaling
N00033
EGF
→
EGFR
→
PI3K
→
PIP3
→
AKT
⊣
BAD
N00514
EGFR*
→
PI3K
→
PIP3
→
AKT
⊣
BAD
N00035
EGFR*
→
PI3K
→
PIP3
→
AKT
→
MTOR
N00042
EGFR*
→
PI3K
→
PIP3
→
AKT
→
MTOR
→
S6K
N00039
PDGF
→
PDGFR
→
PI3K
→
PIP3
→
AKT
→
MTOR
→
S6K
N00040
PDGFR*
→
PI3K
→
PIP3
→
AKT
→
MTOR
N00220
PTEN
⊣
PIP3
→
AKT
N00051
PTEN*
⌿
PIP3
→
AKT
N00052
PTEN*
⌿
PIP3
→
AKT
Calcium signaling
N00026
EGF
→
EGFR
→
PLCG
→
IP3
→
Ca2+
→
CALM
=
CAMK
N00027
EGFR*
→
PLCG
→
IP3
→
Ca2+
→
CALM
=
CAMK
N00028
PDGF
→
PDGFR
→
PLCG
→
IP3
→
Ca2+
→
CALM
=
CAMK
N00029
PDGFR*
→
PLCG
→
IP3
→
Ca2+
→
CALM
=
CAMK
Cell cycle
N00066
CDKN2A
⊣
MDM2
⊣
TP53
⇒
CDKN1A
⊣
(CCND+CDK4/6)
→
RB1
⌿
E2F
N00067
CDKN2A*
⌿
MDM2
⊣
TP53
⇒
CDKN1A
⊣
(
CCND
+
CDK4/6
)
→
RB1
⌿
E2F
N00068
MDM2*
⊣
TP53
⇒
CDKN1A
⊣
(
CCND
+
CDK4/6
)
→
RB1
⌿
E2F
N00069
CDKN2A
⊣
(CCND+CDK4/6)
→
RB1
⌿
E2F
N00071
CDKN2A*
⌿
(
CCND
+
CDK4/6
)
→
RB1
⌿
E2F
N00072
(
CCND
+
CDK4*
)
→
RB1
⌿
E2F
N00074
RB1*
⌿
E2F
Transcription
N00115
TP53*
⌿
(
CDKN1A
,
GADD45
,
BAX..
Drug name
D1
D12291
Tovorafenib (USAN/INN)