KEGG    Network variation - PI3K signaling
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ENTRYnt06530
NamePI3K signaling
CategoryPathway view; Signal transduction
Pathwayhsa04151 PI3K-Akt signaling pathway
Display drug-target relation   disease type
N01656    GFRTKPI3KPIP3AKT
    Many cancers GF*
    Many cancers   RTK*
    ALS19 NRGERBB4*
    BC     PIK3CA*
    PROS     PIK3CA*
    MPPH1     PIK3R2*
    CWS6/PS         AKT1*
    HIHGHH         AKT2*
    MPPH2         AKT3*
N00220        PTENPIP3AKT
    Many cancers     PTEN*
    CWS1/MAS     PTEN*
N00355          PP2AAKT
    NEDLBA       PPP2CA*
    MRD36       PPP2R1A*
    SCA12       PPP2R2B*
    SPGF36       PPP2R3C*
    MRD35       PPP2R5D*
 
N01658    GFRTKGRB2SOSRASPI3KPIP3AKT
    Many cancers         RAS*
    AML   FLT3*
    EN   FGFR3*
    EN         NRAS*
    EN         HRAS*
    EN           PIK3CA*
 
N01657    (GPCR+GNB+GNG)PI3KgammaPIP3AKT
    MRD42 GNB1*
    IMD97   PIK3CG*
    AOA3   PIK3R5*
 
N01163    NRGERBB4PI3KPIP3AKT

Disease nameDisease category
ALS19H00058Amyotrophic lateral sclerosis (ALS)Neurodegenerative disease
BCH00031Breast cancerCancer
PROSH02647MacrodactylyCongenital malformation
H02153Megalencephaly-capillary malformation syndromeCongenital malformation
H01912Congenital lipomatous overgrowth, vascular malformations, and epidermal neviCongenital malformation
H02297CLAPO syndromeCongenital malformation
H00534Cerebral cavernous malformationCongenital malformation
H01222Cowden syndromeCongenital malformation
MPPH1H01885Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndromeCongenital malformation
CWS6/PSH01222Cowden syndromeCongenital malformation
H02119Proteus syndromeCongenital malformation
HIHGHHH01909Hypoinsulinemic hypoglycemia with hemihypertrophyInherited metabolic disorder
MPPH2H01885Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndromeCongenital malformation
CWS1/MASH01222Cowden syndromeCongenital malformation
H02723Macrocephaly/autism syndromeCongenital malformation
NEDLBAH02632Houge-Janssens syndromeCongenital malformation
MRD36H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
SCA12H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
SPGF36H01282Spermatogenic failureReproductive system disease
MRD35H02632Houge-Janssens syndromeCongenital malformation
AMLH00003Acute myeloid leukemiaCancer
ENH02627Epidermal nevusCongenital malformation
MRD42H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
IMD97H00093Combined immunodeficiencyPrimary immunodeficiency
AOA3H00848Ataxia with ocular apraxiaNervous system disease