KEGG   DRUG: Azelastine hydrochlorideHelp
Entry
D00659                      Drug                                   

Name
Azelastine hydrochloride (JP17/USP);
Astelin (TN)
Product
  Generic
AZELASTINE HYDROCHLORIDE (A-S Medication Solutions), AZELASTINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), AZELASTINE (Ascend Laboratories), AZELASTINE HCL NASAL (Perrigo New York), AZELASTINE HYDROCHLORIDE (A-S Medication Solutions), AZELASTINE HYDROCHLORIDE (Akorn), AZELASTINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), AZELASTINE HYDROCHLORIDE (Apotex Corp.), AZELASTINE HYDROCHLORIDE (Apotex Corp.), AZELASTINE HYDROCHLORIDE (Apotex Corp.), AZELASTINE HYDROCHLORIDE (AvKARE), AZELASTINE HYDROCHLORIDE (Breckenridge Pharmaceutical), AZELASTINE HYDROCHLORIDE (Cadila Healthcare Limited), AZELASTINE HYDROCHLORIDE (H.J. Harkins Company), AZELASTINE HYDROCHLORIDE (Hi-Tech Pharmacal), AZELASTINE HYDROCHLORIDE (Hi-Tech Pharmacal), AZELASTINE HYDROCHLORIDE (NuCare Pharmaceuticals), AZELASTINE HYDROCHLORIDE (Sandoz), AZELASTINE HYDROCHLORIDE (Somerset Therapeutics), AZELASTINE HYDROCHLORIDE (Sun Pharmaceutical Industries), AZELASTINE HYDROCHLORIDE (Sun Pharmaceutical Industries), AZELASTINE HYDROCHLORIDE (Wallace Pharmaceuticals), AZELASTINE HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.), AZELASTINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), AZELASTINE HYDROCHLORIDE OPHTHALMIC SOLUTION 0.05% (Alembic Pharmaceuticals)
Formula
C22H24ClN3O. HCl
Exact mass
417.1375
Mol weight
418.3594
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Remark
Therapeutic category: 4490
ATC code: R01AC03 R06AX19 S01GX07
Chemical structure group: DG01036
Product (DG01036): D00659<JP/US>
Product (mixture): D11656<US>
Efficacy
Antiallergic, Antiasthmatic, H1 receptor antagonist
  Disease
Allergic rhinitis [DS:H01360]
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07212  Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AC Antiallergic agents, excl. corticosteroids
     R01AC03 Azelastine
      D00659  Azelastine hydrochloride (JP17/USP) <JP/US>
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AX Other antihistamines for systemic use
     R06AX19 Azelastine
      D00659  Azelastine hydrochloride (JP17/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01G DECONGESTANTS AND ANTIALLERGICS
    S01GX Other antiallergics
     S01GX07 Azelastine
      D00659  Azelastine hydrochloride (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Anti-allergy Agents
   Antihistamine
    Azelastine
     D00659  Azelastine hydrochloride (JP17/USP)
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Histamine (H1) Receptor Antagonists, Mildly/Non-sedating
    Azelastine
     D00659  Azelastine hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D00659  Azelastine hydrochloride (JP17/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Allergic agents
  52 Antihistamine based drugs
   D00659  Azelastine hydrochloride (JP17/USP)
  53 Other allergic agents
   D00659  Azelastine hydrochloride (JP17/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Azelastine
    D00659  Azelastine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D00659  Azelastine hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00659  Azelastine hydrochloride
  D00659  Azelastine hydrochloride granules
Rx-to-OTC switch list in Japan [br08314.html]
 D00659
BRITE hierarchy
Other DBs
CAS: 79307-93-0
PubChem: 7847725
ChEBI: 2951
ChEMBL: CHEMBL1200809
DrugBank: DB00972
LigandBox: D00659
NIKKAJI: J364.889C
LinkDB All DBs
KCF data Show

ATOM        28
            1   X   Cl   31.8050  -18.2160
            2   C1y C    27.4868  -20.1967
            3   C1x C    28.5815  -19.3346
            4   C1x C    29.9443  -19.6454
            5   N1y N    30.5451  -20.8963
            6   C1x C    27.4868  -21.6031
            7   C1x C    29.9452  -22.1612
            8   C1x C    28.5815  -22.4722
            9   N4y N    26.2277  -19.5856
            10  N5x N    26.2845  -18.1858
            11  C8y C    24.9979  -17.4984
            12  C8y C    23.7944  -18.2084
            13  C8y C    23.8074  -19.6086
            14  C8y C    25.0240  -20.2960
            15  C8x C    22.5778  -17.5209
            16  C8x C    21.3741  -18.2308
            17  C8x C    21.3171  -19.6311
            18  C8x C    22.6037  -20.3185
            19  C1b C    24.9845  -16.0905
            20  C8y C    26.2038  -15.4501
            21  C8x C    27.4009  -16.2066
            22  C8x C    28.7080  -15.5568
            23  C8y C    28.6938  -14.1607
            24  C8x C    27.4969  -13.4042
            25  C8x C    26.1898  -14.0539
            26  X   Cl   29.9185  -13.5170
            27  C1a C    31.9483  -20.9628
            28  O5x O    24.9670  -21.6792
BOND        30
            1     4   5 1
            2     2   6 1
            3     5   7 1
            4     3   4 1
            5     6   8 1
            6     2   3 1
            7     7   8 1
            8     2   9 1
            9     9  10 1
            10   10  11 2
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14    9  14 1
            15   12  15 2
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   13  18 2
            20   11  19 1
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   23  24 1
            26   24  25 2
            27   20  25 1
            28   23  26 1
            29    5  27 1
            30   14  28 2

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