KEGG   DRUG: Acetohexamide
Entry
D00219                      Drug                                   
Name
Acetohexamide (JP18/USP/INN);
Dymelor (TN)
Formula
C15H20N2O4S
Exact mass
324.1144
Mol weight
324.40
Structure
Simcomp
Class
Antidiabetic agent
 DG01508  Sulfonylurea receptor agonist
  DG01734  Sulfonylurea
 DG02044  Hypoglycemic agent
  DG01734  Sulfonylurea
Remark
Same as: C06806
Therapeutic category: 3961
ATC code: A10BB31
Product: D00219<JP>
Efficacy
Antidiabetic, Hypoglycemic, Sulfonylurea receptor agonist
Comment
Sulfonylurea
Target
ABCC8 (SUR1) [HSA:6833] [KO:K05032]
  Pathway
hsa02010  ABC transporters
hsa04911  Insulin secretion
hsa04930  Type II diabetes mellitus
Interaction
Structure map
map07018  Sulfonamide derivatives - hypoglycemic agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BB Sulfonylureas
     A10BB31 Acetohexamide
      D00219  Acetohexamide (JP18/USP/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3961  Sulfonylureas
     D00219  Acetohexamide (JP18/USP/INN)
Drug groups [BR:br08330]
 Antidiabetic agent
  DG01508  Sulfonylurea receptor agonist
   DG01734  Sulfonylurea
    D00219  Acetohexamide
  DG02044  Hypoglycemic agent
   DG01734  Sulfonylurea
    D00219  Acetohexamide
Drug classes [BR:br08332]
 Antidiabetic agent
  DG01734  Sulfonylurea
   D00219  Acetohexamide
  DG02044  Hypoglycemic agent
   D00219  Acetohexamide
Target-based classification of drugs [BR:br08310]
 Transporters
  ABC transporters
   ABCC subfamily
    ABCC8 (SUR1)
     D00219  Acetohexamide (JP18/USP/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00219  Acetohexamide
Other DBs
CAS: 968-81-0
PubChem: 7847286
ChEBI: 28052
PDB-CCD: TF9[PDBj]
LigandBox: D00219
NIKKAJI: J3.355C
LinkDB
KCF data

ATOM        22
            1   C8x C    21.1400  -10.5000
            2   C8y C    21.1400  -11.9000
            3   C8x C    22.3524  -12.6000
            4   C8x C    23.5649  -11.9000
            5   C8y C    23.5649  -10.5000
            6   C8x C    22.3524   -9.8000
            7   S4a S    24.7960   -9.7890
            8   N1b N    26.0012  -10.4847
            9   C5a C    19.9276  -12.6000
            10  C1a C    18.7321  -11.9096
            11  O5a O    19.9275  -13.9998
            12  C5a C    27.1835   -9.8019
            13  N1b N    28.3775  -10.4912
            14  O5a O    27.1835   -8.4002
            15  C1y C    29.5654   -9.8052
            16  C1x C    30.7565  -10.4929
            17  C1x C    31.9690   -9.7929
            18  C1x C    31.9690   -8.3929
            19  C1x C    30.7779   -7.7052
            20  C1x C    29.5655   -8.4052
            21  O3c O    25.7860   -8.7990
            22  O3c O    23.8061   -8.7990
BOND        23
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     2   9 1
            10    9  10 1
            11    9  11 2
            12    8  12 1
            13   12  13 1
            14   12  14 2
            15   13  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   15  20 1
            22    7  21 2
            23    7  22 2

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