| Entry |
|
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| Name |
Buclizine hydrochloride (USAN);
Vibazine (TN) |
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| Formula |
C28H33ClN2. 2HCl
|
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| Exact mass |
504.1866
|
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| Mol weight |
505.94
|
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| Structure |
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| Simcomp |
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| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
|
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| Remark |
|
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| Efficacy |
Antiallergic, Anti-emetic, H1 receptor antagonist |
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04750 | Inflammatory mediator regulation of TRP channels |
|
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| Interaction |
|
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| Structure map |
| map07212 | Histamine H1 receptor antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AE Piperazine derivatives
R06AE01 Buclizine
D02089 Buclizine hydrochloride (USAN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01104 Buclizine
D02089 Buclizine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D02089 Buclizine hydrochloride (USAN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01104 Buclizine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 33
1 C1c C 14.7471 -16.0735
2 N1y N 14.7471 -14.6713
3 C8y C 13.5312 -16.7833
4 C8y C 15.9574 -16.7890
5 C1x C 13.5312 -13.9789
6 C1x C 15.9690 -13.9905
7 C8x C 13.5370 -18.1854
8 C8x C 12.3268 -16.0794
9 C8x C 15.9515 -18.1854
10 C8x C 17.1734 -16.0908
11 C1x C 13.5020 -12.5884
12 C1x C 15.9690 -12.5884
13 C8x C 12.3268 -18.8836
14 C8x C 11.1109 -16.7833
15 C8x C 17.1618 -18.8895
16 C8x C 18.3836 -16.8007
17 N1y N 14.7647 -11.8902
18 C8y C 11.1109 -18.1854
19 C8x C 18.3778 -18.1971
20 C1b C 14.7588 -10.4937
21 X Cl 9.9005 -18.8836
22 C8y C 15.9690 -9.8014
23 C8x C 17.1734 -10.4937
24 C8x C 15.9690 -8.4050
25 C8x C 18.3895 -9.8014
26 C8x C 17.1792 -7.7009
27 C8y C 18.3895 -8.4050
28 C1d C 19.5938 -7.6893
29 C1a C 19.5879 -6.2929
30 C1a C 20.2803 -8.8996
31 C1a C 20.9437 -7.3229
32 X Cl 23.6337 -11.3510
33 X Cl 23.6337 -12.9830
BOND 34
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 3 8 2
8 4 9 2
9 4 10 1
10 5 11 1
11 6 12 1
12 7 13 2
13 8 14 1
14 9 15 1
15 10 16 2
16 11 17 1
17 13 18 1
18 15 19 2
19 17 20 1
20 18 21 1
21 20 22 1
22 22 23 2
23 22 24 1
24 23 25 1
25 24 26 2
26 25 27 2
27 27 28 1
28 28 29 1
29 28 30 1
30 28 31 1
31 12 17 1
32 14 18 2
33 16 19 1
34 26 27 1
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