| Entry |
|
|---|
| Name |
Trimetrexate (USAN/INN) |
|---|
| Formula |
C19H23N5O3
|
|---|
| Exact mass |
369.1801
|
|---|
| Mol weight |
369.4176
|
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| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antineoplastic
DG01930 Dihydrofolate reductase inhibitor, antineoplastic
DG01978 Folic acid analog
DG01930 Dihydrofolate reductase inhibitor, antineoplastic
DG02018 Antimetabolite
DG01978 Folic acid analog
DG01930 Dihydrofolate reductase inhibitor, antineoplastic
|
|---|
| Remark |
|
|---|
| Efficacy |
Antineoplastic, Antimetabolite |
|---|
| Target |
|
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| Pathway |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07041 | Antineoplastics - antimetabolic agents |
|
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| Other map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
P01 ANTIPROTOZOALS
P01A AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES
P01AX Other agents against amoebiasis and other protozoal diseases
P01AX07 Trimetrexate
D06238 Trimetrexate (USAN/INN)
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Dihydrofolate reductase
DHFR
D06238 Trimetrexate (USAN/INN)
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 27
1 C8y C 21.0843 -15.4785
2 N1b N 19.8938 -14.7782
3 C8x C 22.3449 -14.7782
4 C8x C 21.0843 -16.8792
5 C1b C 18.7033 -15.4785
6 C8y C 23.5354 -15.4785
7 C8y C 22.3449 -17.5795
8 C8y C 23.5354 -16.8792
9 O2a O 24.7260 -14.7782
10 O2a O 22.3449 -18.9801
11 O2a O 24.7260 -17.5094
12 C1a C 25.9165 -15.4785
13 C1a C 21.1544 -19.6804
14 C1a C 24.7260 -18.9801
15 C8y C 17.5127 -14.7782
16 C8x C 17.5127 -13.3776
17 C8x C 16.2522 -12.7473
18 C8y C 15.0616 -13.4476
19 C8y C 15.0616 -14.7782
20 C8y C 16.2522 -15.4785
21 N5x N 13.8011 -12.7473
22 C8y C 12.6105 -13.4476
23 N5x N 12.6105 -14.7782
24 C8y C 13.8711 -15.4785
25 C1a C 16.2522 -16.9492
26 N1a N 13.8711 -16.9492
27 N1a N 11.4200 -12.7473
BOND 29
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 1
5 3 6 2
6 4 7 1
7 6 8 1
8 6 9 1
9 7 10 1
10 8 11 1
11 9 12 1
12 10 13 1
13 11 14 1
14 7 8 2
15 5 15 1
16 15 16 2
17 16 17 1
18 17 18 2
19 18 19 1
20 19 20 2
21 15 20 1
22 18 21 1
23 21 22 2
24 22 23 1
25 23 24 2
26 19 24 1
27 20 25 1
28 24 26 1
29 22 27 1
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