KEGG   DRUG: Meclofenamate sodium
Entry
D08162                      Drug                                   

Name
Meclofenamate sodium;
Meclomen (TN)
Formula
C14H10Cl2NO2. Na
Exact mass
316.9986
Mol weight
318.1305
Structure
Simcomp
Class
Anti-inflammatory
 DG01911  Anti-inflammatory drug, fenamic acid derivatives
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01911  Anti-inflammatory drug, fenamic acid derivatives
Remark
Same as: C02996
ATC code: M01AG04 M02AA18
Chemical structure group: DG00758
Product (DG00758): D00169<US>
Efficacy
Anti-inflammatory, COX inhibitor
Comment
Fenamic acid derivative
nonsteroidal anti-inflammatory drug (NSAID)
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AG Fenamates
     M01AG04 Meclofenamic acid
      D08162  Meclofenamate sodium
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA18 Meclofenamic acid
      D08162  Meclofenamate sodium
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D08162  Meclofenamate sodium
    PTGS2 (COX2)
     D08162  Meclofenamate sodium
Other DBs
CAS: 6385-02-0
PubChem: 96024852
ChEBI: 6711
ChEMBL: CHEMBL876
LigandBox: D08162
NIKKAJI: J8.403D
LinkDB
KCF data

ATOM        20
            1   C8y C    23.9400  -18.2700
            2   N1b N    22.6800  -17.5700
            3   C8y C    25.1300  -17.5700
            4   C8y C    23.9400  -19.6700
            5   C8y C    21.4900  -18.2700
            6   C8y C    26.3200  -18.2700
            7   X   Cl   25.1300  -16.1700
            8   C8x C    25.1300  -20.3700
            9   X   Cl   22.6800  -20.3700
            10  C8y C    20.3000  -17.5700
            11  C8x C    21.4900  -19.6700
            12  C8x C    26.3200  -19.6700
            13  C1a C    27.5800  -17.5700
            14  C8x C    19.0400  -18.2700
            15  C6a C    20.3000  -16.1700
            16  C8x C    20.3000  -20.3700
            17  C8x C    19.0400  -19.6700
            18  O6a O    19.0400  -15.4700
            19  O6a O    21.4900  -15.4700 #-
            20  Z   Na   29.2600  -19.5300 #+
BOND        20
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     3   6 2
            6     3   7 1
            7     4   8 1
            8     4   9 1
            9     5  10 2
            10    5  11 1
            11    6  12 1
            12    6  13 1
            13   10  14 1
            14   10  15 1
            15   11  16 2
            16   14  17 2
            17   15  18 2
            18   15  19 1
            19    8  12 2
            20   16  17 1

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