KEGG   DRUG: Trolamine salicylate
Entry
D08501            Mixture   Drug                                   

Name
Trolamine salicylate (USP);
Salicylic acid trolamine;
Salicylic acid triethanolamine;
Arthricream (TN)
Formula
C6H15NO3. C7H6O3
Exact mass
287.1369
Mol weight
287.3089
Structure
Component
Trolamine [DR:D00215], Salicylic acid [DR:D00097]
Class
Anti-inflammatory
 DG01909  Anti-inflammatory drug, salicylic acid derivatives
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01909  Anti-inflammatory drug, salicylic acid derivatives
Remark
ATC code: D03AX12
Efficacy
Analgesic, Anti-inflammatory, Antipyretic, Keratolytic
Comment
Salicylic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D03 PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS
   D03A CICATRIZANTS
    D03AX Other cicatrizants
     D03AX12 Trolamine
      D08501  Trolamine salicylate (USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D08501  Trolamine salicylate (USP)
    PTGS2 (COX2)
     D08501  Trolamine salicylate (USP)
Other DBs
CAS: 2174-16-5
PubChem: 96025186
ChEMBL: CHEMBL2107288
LigandBox: D08501
LinkDB
KCF data

ATOM        20
            1   C8y C    12.5203  -15.7950
            2   C8y C    13.7835  -16.4968
            3   C8x C    11.3272  -16.4968
            4   C6a C    12.5204  -14.3914
            5   C8x C    13.7835  -17.9004
            6   O1a O    14.9765  -15.7950
            7   C8x C    11.3272  -17.9004
            8   O6a O    13.7837  -13.6896
            9   O6a O    11.3274  -13.6896
            10  C8x C    12.5203  -18.6022
            11  N1c N    22.2752  -16.2161
            12  C1b C    22.2752  -14.8125
            13  C1b C    21.0597  -16.9179
            14  C1b C    23.4907  -16.9179
            15  C1b C    24.6893  -16.2257
            16  O1a O    25.8797  -16.9130
            17  C1b C    19.8611  -16.2257
            18  O1a O    18.6707  -16.9130
            19  C1b C    23.4907  -14.1107
            20  O1a O    24.6893  -14.8029
BOND        19
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     5  10 1
            10    7  10 2
            11   11  12 1
            12   11  13 1
            13   11  14 1
            14   14  15 1
            15   15  16 1
            16   13  17 1
            17   17  18 1
            18   12  19 1
            19   19  20 1

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