KEGG   DRUG: Pamrevlumab
Entry
D10969                      Drug                                   

Name
Pamrevlumab (USAN/INN)
Sequence
(Heavy chain)
EGQLVQSGGG LVHPGGSLRL SCAGSGFTFS SYGMHWVRQA PGKGLEWVSG IGTGGGTYST
DSVKGRFTIS RDNAKNSLYL QMNSLRAEDM AVYYCARGDY YGSGSFFDCW GQGTLVTVSS
ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKRVEP KSCDKTHTCP PCPAPELLGG
PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN
STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSREE
MTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW
QQGNVFSCSV MHEALHNHYT QKSLSLSPG
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCRASQGIS SWLAWYQQKP EKAPKSLIYA ASSLQSGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQQ YNSYPPTFGQ GTKLEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H95, H147-H203, H223-L214, H229-H'229, H232-H'232, H264-H324, H370-H428, H'22-H'95, H'147-H'203, H'223-L'214, H'264-H'324, H'370-H'428, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Efficacy
Antifibrotic, Antineoplastic, Connective tissue growth factor inhibitor
Comment
Monoclonal antibody
Target
CTGF [HSA:1490] [KO:K06827]
  Pathway
hsa04371  Apelin signaling pathway
hsa04390  Hippo signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Cell adhesion molecules: other families
   CAM ligands
    CTGF
     D10969  Pamrevlumab (USAN/INN)
Other DBs
CAS: 946415-13-0
PubChem: 350078329
LinkDB

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