KEGG   NETWORK: N10003Help
Entry
N10003                      Network                                

Name
First-generation tyrosine kinase inhibitor to ALK fusion
Definition
Crizotinib -| (EML4-ALK,CD74/SLC34A2-ROS1)
  Expanded
D09731 -| (238v1,6098v1)
Class
nt06210 ERK signaling
nt06266 Non-small cell lung cancer
nt06214 PI3K signaling
nt06219 JAK-STAT signaling
Type
Drug target
Gene
238  ALK; ALK receptor tyrosine kinase
6098  ROS1; ROS proto-oncogene 1, receptor tyrosine kinase
Variant
238v1  EML4-ALK fusion
6098v1  ROS1 fusion
Perturbant
D09731  Crizotinib
Reference
  Authors
Mano H
  Title
The EML4-ALK oncogene: targeting an essential growth driver in human cancer.
  Journal
Proc Jpn Acad Ser B Phys Biol Sci 91:193-201 (2015)
DOI:10.2183/pjab.91.193
Reference
  Authors
Rothschild SI, Gautschi O
  Title
Crizotinib in the treatment of non--small-cell lung cancer.
  Journal
Clin Lung Cancer 14:473-80 (2013)
DOI:10.1016/j.cllc.2013.04.006
LinkDB All DBs

DBGET integrated database retrieval system