KEGG   DRUG: VancomycinHelp
Entry
D00212                      Drug                                   

Name
Vancomycin (USP);
VCM;
Vancocin (TN)
Formula
C66H75Cl2N9O24
Exact mass
1447.4302
Mol weight
1449.2536
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Source
Amycolatopsis orientalis [TAX:31958], Streptomyces orientalis [TAX:31958]
Class
Antibacterial
 DG01580  Glycopeptide antibiotic
Remark
Same as: C06689
ATC code: A07AA09 J01XA01
Chemical structure group: DG00086
Product (DG00086): D00926<JP/US>
Efficacy
Antibacterial, Cell wall biosynthesis inhibitor
Comment
Natural product
Glycopeptide
Vancomycin makes complex formation with D-alanyl-D-alanine of Peptidoglycan, and inhibites cross-link between protein and peptideglycan.
Target
peptidoglycan (D-Ala-D-Ala)
  Pathway
ko00550  Peptidoglycan biosynthesis
Interaction
Drug interaction
Biosynthesis
map01055  Biosynthesis of vancomycin group antibiotics
Other map
map01503  Cationic antimicrobial peptide (CAMP) resistance
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07A INTESTINAL ANTIINFECTIVES
    A07AA Antibiotics
     A07AA09 Vancomycin
      D00212  Vancomycin (USP)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01X OTHER ANTIBACTERIALS
    J01XA Glycopeptide antibacterials
     J01XA01 Vancomycin
      D00212  Vancomycin (USP)
USP drug classification [BR:br08302]
 Antibacterials
  Antibacterials, Other
   Vancomycin
    D00212  Vancomycin (USP)
BRITE hierarchy
Other DBs
CAS: 1404-90-6
PubChem: 7847279
ChEBI: 28001
ChEMBL: CHEMBL262777 CHEMBL3735877
DrugBank: DB00512
LigandBox: D00212
NIKKAJI: J34.275K
LinkDB All DBs
KCF data Show

ATOM        101
            1   C1y C    22.1523  -23.0181
            2   C1x C    22.1616  -21.6755
            3   O2x O    23.3049  -23.6865
            4   C1z C    23.3233  -21.0234
            5   C1y C    24.4667  -23.0342
            6   C1y C    24.4759  -21.6916
            7   C1a C    22.3951  -19.9369
            8   N1a N    24.2867  -19.9500
            9   C1a C    25.6267  -23.7026
            10  O1a O    25.6451  -21.0396
            11  C8y C    19.9288  -18.7446
            12  C8y C    21.0859  -18.0770
            13  C8y C    18.7713  -18.0843
            14  O2a O    19.9371  -20.0799
            15  C8x C    21.0786  -16.7343
            16  O2x O    22.2358  -18.7373
            17  C8x C    18.7640  -16.7491
            18  O2x O    17.6068  -18.7373
            19  C1y C    18.7766  -21.8455
            20  C8y C    19.9139  -16.0667
            21  C8y C    23.4004  -18.0696
            22  C8y C    16.4420  -18.0770
            23  C1y C    18.7766  -23.1881
            24  O2x O    17.6121  -21.1779
            25  C1y C    19.9467  -13.9511
            26  C8y C    23.4004  -16.7343
            27  C8x C    24.5577  -18.7298
            28  C8y C    15.2849  -18.7373
            29  C8x C    16.4346  -16.7343
            30  C1y C    17.6268  -23.8707
            31  C1y C    16.4474  -21.8604
            32  C5x C    21.0265  -13.2760
            33  N1x N    18.7270  -13.2833
            34  C8x C    24.5577  -16.0591
            35  X   Cl   22.2358  -16.0518
            36  C8x C    25.7075  -18.0696
            37  C8x C    14.1275  -18.0843
            38  X   Cl   15.2774  -20.0726
            39  C8x C    15.2701  -16.0667
            40  C1y C    16.4546  -23.2105
            41  O1a O    17.6194  -25.1986
            42  N1x N    22.1913  -13.9511
            43  O5x O    21.0192  -11.9407
            44  C5x C    17.5695  -13.9584
            45  C8y C    25.7075  -16.7343
            46  C8y C    14.1203  -16.7491
            47  O1a O    15.2899  -23.8632
            48  C1y C    23.3411  -13.2760
            49  C1y C    16.4124  -13.2909
            50  O5x O    17.5623  -15.2937
            51  C1y C    26.8574  -16.0518
            52  C1y C    12.9555  -16.0667
            53  C8y C    23.2785  -11.9407
            54  C5x C    24.4983  -13.9435
            55  N1x N    15.2552  -13.9660
            56  C1y C    26.8499  -13.9511
            57  O1a O    28.0146  -16.7270
            58  C1y C    12.9481  -13.9733
            59  O1a O    11.7908  -16.7343
            60  C8x C    24.5058  -11.2729
            61  C8x C    22.1840  -11.2729
            62  N1x N    25.6554  -13.2685
            63  C5x C    14.1054  -13.2982
            64  C5x C    28.0073  -13.2760
            65  N1b N    11.7834  -13.3057
            66  C8y C    24.5058   -9.9303
            67  C8x C    22.1840   -9.9376
            68  O5x O    14.1678  -11.9629
            69  N1x N    27.9998  -11.9407
            70  O5x O    29.1645  -13.9511
            71  C5a C    10.6261  -13.9660
            72  C8y C    25.6703   -9.2774
            73  C8y C    23.3411   -9.2625
            74  C1y C    26.8350  -11.2729
            75  C1c C     9.4688  -13.2982
            76  O5a O    10.6187  -15.3010
            77  C8y C    26.8277   -9.9376
            78  C8y C    25.6630   -7.9347
            79  C6a C    29.0755   -9.9897
            80  C1b C     9.4615  -11.9629
            81  N1b N     8.3041  -13.9584
            82  C8x C    27.9849   -9.2625
            83  C8x C    26.8129   -7.2596
            84  O1a O    24.4983   -7.2596
            85  C8y C    27.9776   -7.9198
            86  O1a O    29.1273   -7.2375
            87  O5x O    24.5017  -15.3103
            88  O1a O    23.3357   -7.8673
            89  O6a O    30.2660  -10.6825
            90  O6a O    29.0800   -8.6255
            91  C1a C     8.3012  -15.3102
            92  C1c C     8.2758  -11.2878
            93  C1a C     7.0582  -12.0004
            94  C1a C     8.2672   -9.9349
            95  C1b C    16.4087  -11.1067
            96  C5a C    17.5830  -10.4243
            97  N1a N    18.7559  -11.0972
            98  O5a O    17.5793   -9.0391
            99  C1b C    15.2538  -21.1805
            100 O1a O    14.0910  -21.8612
            101 O2a O    20.3945  -23.8738
BOND        110
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1
            6     4   7 1 #Up
            7     4   8 1 #Down
            8     5   9 1 #Down
            9     6  10 1 #Down
            10    5   6 1
            11   11  12 1
            12   11  13 2
            13   11  14 1
            14   12  15 2
            15   12  16 1
            16   13  17 1
            17   13  18 1
            18   19  14 1 #Up
            19   15  20 1
            20   16  21 1
            21   18  22 1
            22   19  23 1
            23   19  24 1
            24   20  25 1
            25   21  26 1
            26   21  27 2
            27   22  28 1
            28   22  29 2
            29   23  30 1
            30   24  31 1
            31   25  32 1
            32   25  33 1 #Up
            33   26  34 2
            34   26  35 1
            35   27  36 1
            36   28  37 2
            37   28  38 1
            38   29  39 1
            39   30  40 1
            40   30  41 1 #Up
            41   32  42 1
            42   32  43 2
            43   33  44 1
            44   34  45 1
            45   37  46 1
            46   40  47 1 #Down
            47   42  48 1
            48   44  49 1
            49   44  50 2
            50   45  51 1
            51   46  52 1
            52   48  53 1
            53   48  54 1 #Down
            54   49  55 1
            55   51  56 1
            56   51  57 1 #Down
            57   52  58 1
            58   52  59 1 #Up
            59   53  60 1
            60   53  61 2
            61   54  62 1
            62   55  63 1
            63   56  64 1
            64   58  65 1 #Up
            65   60  66 2
            66   61  67 1
            67   63  68 2
            68   64  69 1
            69   64  70 2
            70   65  71 1
            71   66  72 1
            72   66  73 1
            73   69  74 1
            74   71  75 1
            75   71  76 2
            76   72  77 2
            77   72  78 1
            78   74  79 1 #Down
            79   75  80 1
            80   75  81 1 #Down
            81   77  82 1
            82   78  83 2
            83   78  84 1
            84   82  85 2
            85   85  86 1
            86   17  20 2
            87   31  40 1
            88   36  45 2
            89   39  46 2
            90   56  62 1 #Down
            91   58  63 1
            92   67  73 2
            93   74  77 1
            94   83  85 1
            95   54  87 2
            96   73  88 1
            97   79  89 1
            98   79  90 2
            99   81  91 1
            100  80  92 1
            101  92  93 1
            102  92  94 1
            103  49  95 1 #Up
            104  95  96 1
            105  96  97 1
            106  96  98 2
            107  31  99 1 #Up
            108  99 100 1
            109  23 101 1 #Down
            110   1 101 1 #Up

» Japanese version   » Back

DBGET integrated database retrieval system