KEGG   DRUG: EtodolacHelp
Entry
D00315                      Drug                                   

Name
Etodolac (JP17/USP/INN);
Lodine (TN)
Product
  Generic
ETODOLAC (A-S Medication Solutions), ETODOLAC (A-S Medication Solutions), ETODOLAC (A-S Medication Solutions), ETODOLAC (A-S Medication Solutions), ETODOLAC (A-S Medication Solutions), ETODOLAC (ANI Pharmaceuticals), ETODOLAC (Aidarex Pharmaceuticals LLC), ETODOLAC (Aidarex Pharmaceuticals LLC), ETODOLAC (Aidarex Pharmaceuticals LLC), ETODOLAC (Amneal Pharmaceuticals LLC), ETODOLAC (Aphena Pharma Solutions - Tennessee), ETODOLAC (Aphena Pharma Solutions - Tennessee), ETODOLAC (Apotex Corp.), ETODOLAC (Apotex Corp.), ETODOLAC (AvKARE), ETODOLAC (Blenheim Pharmacal), ETODOLAC (Bryant Ranch Prepack), ETODOLAC (Bryant Ranch Prepack), ETODOLAC (Bryant Ranch Prepack), ETODOLAC (Bryant Ranch Prepack), ETODOLAC (Bryant Ranch Prepack), ETODOLAC (Bryant Ranch Prepack), ETODOLAC (Bryant Ranch Prepack), ETODOLAC (Bryant Ranch Prepack), ETODOLAC (Cadila Healthcare Limited), ETODOLAC (California Pharmaceuticals), ETODOLAC (Carilion Materials Management), ETODOLAC (DIRECT RX), ETODOLAC (DIRECT RX), ETODOLAC (DIRECT RX), ETODOLAC (DIRECT RX), ETODOLAC (Dispensing Solutions), ETODOLAC (Dispensing Solutions), ETODOLAC (Eon Labs), ETODOLAC (Golden State Medical Supply), ETODOLAC (H. J. Harkins), ETODOLAC (H.J. HARKINS COMPANY), ETODOLAC (H.J. Harkins Company), ETODOLAC (KAISER FOUNDATION HOSPITALS), ETODOLAC (KAISER FOUNDATION HOSPITALS), ETODOLAC (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ETODOLAC (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ETODOLAC (Lake Erie Medical DBA Quality Care Products LLC), ETODOLAC (Lake Erie Medical DBA Quality Care Products LLC), ETODOLAC (Lake Erie Medical DBA Quality Care Products LLC), ETODOLAC (Lake Erie Medical DBA Quality Care Products LLC), ETODOLAC (NORTHSTAR RX LLC), ETODOLAC (Northwind Pharmaceuticals), ETODOLAC (Northwind Pharmaceuticals), ETODOLAC (NuCare Pharmaceuticals), ETODOLAC (PD-Rx Pharmaceuticals), ETODOLAC (PD-Rx Pharmaceuticals), ETODOLAC (PD-Rx Pharmaceuticals), ETODOLAC (PD-Rx Pharmaceuticals), ETODOLAC (PD-Rx Pharmaceuticals), ETODOLAC (Preferred Pharmaceuticals), ETODOLAC (Preferred Pharmaceuticals), ETODOLAC (Preferred Pharmaceuticals), ETODOLAC (Preferred Pharmaceuticals), ETODOLAC (Preferred Pharmaceuticals), ETODOLAC (Preferred Pharmaceuticals), ETODOLAC (Preferred Pharmaceuticals), ETODOLAC (Proficient Rx LP), ETODOLAC (Proficient Rx LP), ETODOLAC (Proficient Rx LP), ETODOLAC (Proficient Rx LP), ETODOLAC (Rebel Distributors Corp), ETODOLAC (Rebel Distributors Corp), ETODOLAC (Rebel Distributors Corp), ETODOLAC (Rebel Distributors Corp), ETODOLAC (RedPharm Drug), ETODOLAC (RedPharm Drug), LODINE (Sallus Laboratories), ETODOLAC (St. Mary's Medical Park Pharmacy), ETODOLAC (St. Mary's Medical Park Pharmacy), ETODOLAC (St. Mary's Medical Park Pharmacy), ETODOLAC (Taro Pharmaceuticals U.S.A.), ETODOLAC (Taro Pharmaceuticals U.S.A.), ETODOLAC (Teva Pharmaceuticals USA), ETODOLAC (Teva Pharmaceuticals USA), ETODOLAC (Unit Dose Services), ETODOLAC (Unit Dose Services), ETODOLAC (Unit Dose Services), ETODOLAC (Unit Dose Services), ETODOLAC (Zydus Pharmaceuticals (USA))
Formula
C17H21NO3
Exact mass
287.1521
Mol weight
287.3535
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01906  Antiinflammatory drug, acetic acid derivatives
 DG01504  Nonsteroidal antiinflammatory drug (NSAID)
  DG01906  Antiinflammatory drug, acetic acid derivatives
 DG01922  Selective COX2 inhibitor
Remark
Same as: C06991
Therapeutic category: 1149
ATC code: M01AB08
Product: D00315<JP/US>
Efficacy
Analgesic, Anti-inflammatory, COX-2 inhibitor
Comment
Acetic acid derivative
Target
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Drug interaction
Structure map
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AB Acetic acid derivatives and related substances
     M01AB08 Etodolac
      D00315  Etodolac (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Etodolac
    D00315  Etodolac (JP17/USP/INN)
 Anti-inflammatory Agents
  Nonsteroidal Anti-inflammatory Drugs
   Etodolac
    D00315  Etodolac (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00315  Etodolac (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS2 (COX2)
     D00315  Etodolac (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00315  Etodolac
Drug classes of therapeutic agents [br08360.html]
 Antirheumatic and antigout agents
  D00315
 Anesthetics, analgesics and anti-inflammatory drugs
  D00315
BRITE hierarchy
Other DBs
CAS: 41340-25-4
PubChem: 7847381
ChEBI: 4909
ChEMBL: CHEMBL622
DrugBank: DB00749
LigandBox: D00315
NIKKAJI: J16.541G
LinkDB All DBs
KCF data Show

ATOM        21
            1   C8y C    32.4100  -11.0600
            2   C1x C    32.4100  -12.4600
            3   C1x C    33.6224  -13.1600
            4   O2x O    34.8349  -12.4600
            5   C1z C    34.8349  -11.0600
            6   C8y C    33.6224  -10.3600
            7   C1b C    36.0724  -10.3600
            8   C6a C    37.2849  -11.0600
            9   O6a O    38.4973  -10.3600
            10  N4x N    33.3314   -8.9906
            11  C8y C    31.9390   -8.8442
            12  C8y C    31.3696  -10.1232
            13  C8y C    31.1161   -7.7116
            14  C8x C    29.7238   -7.8580
            15  C8x C    29.1544   -9.1369
            16  C8x C    29.9773  -10.2696
            17  C1b C    34.8349   -9.6600
            18  C1a C    36.0660   -8.9490
            19  O6a O    37.2849  -12.4598
            20  C1b C    31.6949   -6.4104
            21  C1a C    33.0987   -6.2621
BOND        23
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    6  10 1
            11   10  11 1
            12   11  12 2
            13    1  12 1
            14   11  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   12  16 1
            19    5  17 1
            20   17  18 1
            21    8  19 2
            22   13  20 1
            23   20  21 1

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