KEGG   DRUG: FluocinonideHelp
Entry
D00325                      Drug                                   

Name
Fluocinonide (JP17/USP/INN);
Lidex (TN);
Vanos (TN)
Product
  Generic
FLUOCINONIDE (A-S Medication Solutions), FLUOCINONIDE (Actavis Pharma), FLUOCINONIDE (Aidarex Pharmaceuticals LLC), FLUOCINONIDE (Amneal Pharmaceuticals LLC), FLUOCINONIDE CREAM (Amneal Pharmaceuticals LLC), FLUOCINONIDE (Cadila Healthcare Limited), FLUOCINONIDE (Central Texas Community Health Centers), FLUOCINONIDE (E. Fougera & Co. a division of Fougera Pharmaceuticals), FLUOCINONIDE (E. Fougera & Co. a division of Fougera Pharmaceuticals), FLUOCINONIDE (E. Fougera & Co. a division of Fougera Pharmaceuticals), FLUOCINONIDE (E. Fougera & Co. a division of Fougera Pharmaceuticals), FLUOCINONIDE (E. Fougera & Co. a division of Fougera Pharmaceuticals), FLUOCINONIDE (E. Fougera & Co. a division of Fougera Pharmaceuticals), FLUOCINONIDE (G&W Laboratories), FLUOCINONIDE (G&W Laboratories), FLUOCINONIDE (Glasshouse Pharmaceuticals Limited Canada), FLUOCINONIDE (Glenmark Pharmaceuticals), FLUOCINONIDE (H.J. Harkins Company), FLUOCINONIDE (IPG PHARMACEUTICALS), FLUOCINONIDE (IPG PHARMACEUTICALS), FLUOCINONIDE (IPG PHARMACEUTICALS), FLUOCINONIDE (Impax Generics), FLUOCINONIDE (Lake Erie Medical DBA Quality Care Products LLC), FLUOCINONIDE (Macleods Pharmaceuticals Limited), FLUOCINONIDE (Mayne Pharma), FLUOCINONIDE (MedVantx), FLUOCINONIDE (NORTHSTAR RX LLC), FLUOCINONIDE (Novel Laboratories), FLUOCINONIDE (Novel Laboratories), FLUOCINONIDE (NuCare Pharmaceuticals), FLUOCINONIDE (NuCare Pharmaceuticals), FLUOCINONIDE (NuCare Pharmaceuticals), FLUOCINONIDE (NuCare Pharmaceuticals), FLUOCINONIDE (NuCare Pharmaceuticals), FLUOCINONIDE (Oceanside Pharmaceuticals), FLUOCINONIDE (Perrigo New York), FLUOCINONIDE (Pharmaceutica North America), FLUOCINONIDE (Preferred Pharmaceuticals), FLUOCINONIDE (Preferred Pharmaceuticals), FLUOCINONIDE (Preferred Pharmaceuticals), FLUOCINONIDE (Preferred Pharmaceuticals), FLUOCINONIDE (Proficient Rx LP), FLUOCINONIDE (Proficient Rx LP), FLUOCINONIDE (REMEDYREPACK), FLUOCINONIDE (RPK Pharmaceuticals), FLUOCINONIDE (Rebel Distributors Corp), FLUOCINONIDE (Taro Pharmaceuticals U.S.A.), FLUOCINONIDE (Taro Pharmaceuticals U.S.A.), FLUOCINONIDE (Taro Pharmaceuticals U.S.A.), FLUOCINONIDE (Teligent Pharma), FLUOCINONIDE (Teligent Pharma), FLUOCINONIDE (Teligent Pharma), FLUOCINONIDE (Teva Pharmaceuticals USA), FLUOCINONIDE (Zydus Pharmaceuticals (USA))
Formula
C26H32F2O7
Exact mass
494.2116
Mol weight
494.5249
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Same as: C07007
Therapeutic category: 2646
ATC code: C05AA11 D07AC08
Product: D00325<JP/US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA11 Fluocinonide
      D00325  Fluocinonide (JP17/USP/INN) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC08 Fluocinonide
      D00325  Fluocinonide (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Fluocinonide
   D00325  Fluocinonide (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D00325  Fluocinonide (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00325  Fluocinonide (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00325  Fluocinonide
Topical steroids potency [br08317.html]
 Classification in the USA
  D00325
 Classification in Japan
  D00325
BRITE hierarchy
Other DBs
CAS: 356-12-7
PubChem: 7847391
ChEBI: 5109
ChEMBL: CHEMBL1501 CHEMBL1708010
DrugBank: DB01047
LigandBox: D00325
NIKKAJI: J2.036B
LinkDB All DBs
KCF data Show

ATOM        35
            1   C2x C    18.6900  -28.5600
            2   C5x C    18.6900  -29.8900
            3   C2x C    19.8800  -30.5900
            4   C2y C    21.0700  -29.8900
            5   C1z C    21.0700  -28.5600
            6   C2x C    19.8800  -27.8600
            7   C1y C    22.2600  -30.5900
            8   C1x C    23.4500  -29.8900
            9   C1y C    23.4500  -28.5600
            10  C1z C    22.2600  -27.8600
            11  C1y C    24.5700  -27.8600
            12  C1z C    24.5700  -26.5300
            13  C1x C    23.4500  -25.8300
            14  C1y C    22.2600  -26.5300
            15  C1x C    26.9500  -27.8600
            16  C1y C    26.9500  -26.5300
            17  C1z C    25.7600  -25.8300
            18  O5x O    17.5700  -30.5900
            19  C1a C    21.0700  -27.1600
            20  X   F    22.2600  -29.1900
            21  O1a O    21.0700  -25.8300
            22  C1a C    24.5700  -25.1300
            23  C5a C    25.7600  -24.2200
            24  O2x O    27.1600  -24.9200
            25  O5a O    26.9500  -23.5200
            26  C1b C    24.5700  -23.5200
            27  O7a O    23.4500  -24.2200
            28  O2x O    28.3500  -26.5300
            29  C1z C    28.5600  -24.9200
            30  C1a C    29.9600  -24.9200
            31  C1a C    28.5600  -23.5200
            32  X   F    22.2600  -31.9900
            33  C7a C    22.2138  -23.5629
            34  C1a C    20.9972  -24.3229
            35  O6a O    22.1654  -22.1902
BOND        39
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   10  20 1 #Down
            24   14  21 1 #Up
            25   12  22 1 #Up
            26   17  23 1 #Up
            27   17  24 1 #Down
            28   23  25 2
            29   23  26 1
            30   26  27 1
            31   16  28 1 #Down
            32   24  29 1
            33   29  28 1
            34   29  30 1
            35   29  31 1
            36    7  32 1 #Down
            37   27  33 1
            38   33  34 1
            39   33  35 2

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