KEGG   DRUG: FlurandrenolideHelp
Entry
D00328                      Drug                                   

Name
Flurandrenolide (USP);
Fludroxycortide (JAN/INN);
Cordran (TN)
Product
  Generic
Formula
C24H33FO6
Exact mass
436.2261
Mol weight
436.5136
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Therapeutic category: 2646
ATC code: D07AC07
Product: D00328<JP/US>
Efficacy
Anti-inflammatory, Antipruritic, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Brite
Lipids [BR:br08002]
 ST  Sterol Lipids
  ST02 Steroids
   ST0203 C21 steroids (gluco/mineralocorticoids, progestogens) and derivatives
    D00328  Flurandrenolide
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC07 Fludroxycortide
      D00328  Flurandrenolide (USP) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Flurandrenolide
   D00328  Flurandrenolide (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D00328  Flurandrenolide (USP); Fludroxycortide (JAN/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00328  Flurandrenolide (USP) <JP/US>
Topical steroids potency [br08317.html]
 Classification in the USA
  D00328
BRITE hierarchy
Other DBs
CAS: 1524-88-5
PubChem: 7847394
ChEBI: 5127
ChEMBL: CHEMBL1201012
DrugBank: DB00846
LigandBox: D00328
NIKKAJI: J3.671D
LinkDB All DBs
KCF data Show

ATOM        31
            1   C1z C    22.9890  -17.6284
            2   C1z C    21.7992  -18.2991
            3   C1y C    24.1674  -18.3284
            4   O2x O    24.3950  -16.9284
            5   C5a C    23.0007  -16.2518
            6   C1y C    21.7816  -19.6641
            7   C1x C    20.6091  -17.5991
            8   C1a C    21.7583  -16.8525
            9   C1x C    24.1500  -19.6934
            10  O2x O    25.6608  -18.3167
            11  C1z C    25.7190  -16.9225
            12  C1b C    21.8225  -15.5518
            13  O5a O    24.2082  -15.5809
            14  C1y C    20.5974  -20.3408
            15  C1y C    19.4192  -18.2758
            16  C1a C    25.6549  -15.7384
            17  C1a C    27.0432  -16.9225
            18  O1a O    21.8399  -14.1809
            19  C1y C    19.4133  -19.6467
            20  C1x C    20.5974  -21.7117
            21  O1a O    18.2408  -17.5758
            22  C1z C    18.2175  -20.3291
            23  C1y C    19.3959  -22.4000
            24  C2y C    18.2117  -21.7000
            25  C1x C    17.0276  -19.6467
            26  C1a C    18.2117  -19.0808
            27  X   F    19.3901  -23.7707
            28  C2x C    17.0276  -22.3941
            29  C1x C    15.8377  -20.3291
            30  C5x C    15.8377  -21.7000
            31  O5x O    14.6476  -22.3941
BOND        35
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1
            7     2   8 1 #Up
            8     3   9 1
            9     3  10 1 #Down
            10    4  11 1
            11    5  12 1
            12    5  13 2
            13    6  14 1
            14    7  15 1
            15   11  16 1
            16   11  17 1
            17   12  18 1
            18   14  19 1
            19   14  20 1
            20   15  21 1 #Up
            21   19  22 1
            22   20  23 1
            23   22  24 1
            24   22  25 1
            25   22  26 1 #Up
            26   23  27 1 #Down
            27   24  28 2
            28   25  29 1
            29   28  30 1
            30   30  31 2
            31    6   9 1
            32   10  11 1
            33   15  19 1
            34   23  24 1
            35   29  30 1

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