KEGG   DRUG: HydroxyureaHelp
Entry
D00341                      Drug                                   

Name
Hydroxyurea (USP);
Hydroxycarbamide (JAN/INN);
Droxia (TN);
Hydrea (TN)
Product
  Generic
Formula
CH4N2O2
Exact mass
76.0273
Mol weight
76.0547
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Remark
Same as: C07044
Therapeutic category: 4229
ATC code: L01XX05
Product: D00341<JP/US>
Efficacy
Antineoplastic, Antimetabolite
  Disease
Chronic myeloid leukemia [DS:H00004]
Carcinoma of the ovary [DS:H00027]
Melanoma [DS:H00038]
Squamous cell carcinoma [DS:H00040]
Sickle cell anemia [DS:H00229]
Target
RRM2 [HSA:6241] [KO:K10808]
  Pathway
hsa00230  Purine metabolism
hsa00240  Pyrimidine metabolism
hsa00480  Glutathione metabolism
hsa04115  p53 signaling pathway
Interaction
Drug interaction
Structure map
map07041  Antineoplastics - antimetabolic agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XX Other antineoplastic agents
     L01XX05 Hydroxycarbamide
      D00341  Hydroxyurea (USP) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Antimetabolites
   Hydroxyurea
    D00341  Hydroxyurea (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   422  Antimetabolites
    4229  Others
     D00341  Hydroxyurea (USP); Hydroxycarbamide (JAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Ribonucleoside-diphosphate reductase
    RRM2
     D00341  Hydroxyurea (USP) <JP/US>
Antineoplastics [br08340.html]
 D00341
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00341
BRITE hierarchy
Other DBs
CAS: 127-07-1
PubChem: 7847407
ChEBI: 44423
ChEMBL: CHEMBL467
DrugBank: DB01005
PDB-CCD: NHY[PDBj]
LigandBox: D00341
NIKKAJI: J2.937H
LinkDB All DBs
KCF data Show

ATOM        5
            1   C5a C    25.2773  -18.3400
            2   N1b N    26.4812  -19.0436
            3   N1a N    24.0675  -19.0436
            4   O5a O    25.2773  -16.9385
            5   O1b O    27.6967  -18.3400
BOND        4
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1

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