KEGG   DRUG: IsoniazidHelp
Entry
D00346                      Drug                                   

Name
Isoniazid (JP17/USP/INN);
Laniazid (TN)
Product
  Generic
ISONIAZID (American Health Packaging), ISONIAZID (Aphena Pharma Solutions - Tennessee), ISONIAZID (Blenheim Pharmacal), ISONIAZID (Blenheim Pharmacal), ISONIAZID (Blenheim Pharmacal), ISONIAZID (Bryant Ranch Prepack), ISONIAZID (Bryant Ranch Prepack), ISONIAZID (Bryant Ranch Prepack), ISONIAZID (CMP Pharma), ISONIAZID (Clinical Solutions Wholesale), ISONIAZID (Contract Pharmacy Services-PA), ISONIAZID (Department of State Health Services), ISONIAZID (Department of State Health Services), ISONIAZID (H.J. Harkins Company), ISONIAZID (Lannett Company), ISONIAZID (Liberty Pharmaceuticals), ISONIAZID (Liberty Pharmaceuticals), ISONIAZID (Marlex Pharmaceuticals), ISONIAZID (Mikart), ISONIAZID (Mikart), ISONIAZID (Mylan Institutional), ISONIAZID (Northwind Pharmaceuticals), ISONIAZID (NuCare Pharmaceuticals), ISONIAZID (PD-Rx Pharmaceuticals), ISONIAZID (PD-Rx Pharmaceuticals), ISONIAZID (Preferred Pharmaceuticals), ISONIAZID (Preferred Pharmaceuticals), ISONIAZID (Proficient Rx LP), ISONIAZID (REMEDYREPACK), ISONIAZID (REMEDYREPACK), ISONIAZID (REMEDYREPACK), ISONIAZID (REMEDYREPACK), ISONIAZID (Rebel Distributors Corp), ISONIAZID (Sandoz), ISONIAZID (State of Florida DOH Central Pharmacy), ISONIAZID (Teva Pharmaceuticals USA), ISONIAZID (VersaPharm Incorporated), ISONIAZID (West-Ward Pharmaceuticals Corp)
Formula
C6H7N3O
Exact mass
137.0589
Mol weight
137.1393
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antibacterial
 DG01966  Antitubercular
Neuropsychiatric agent
 DG01568  MAO inhibitor
  DG01519  Non-selective monoamine oxidase inhibitor
Remark
Same as: C07054
Therapeutic category: 6222
ATC code: J04AC01
Chemical structure group: DG00642
Product (DG00642): D00346<JP/US> D02002<JP>
Product (mixture): D10210<US>
Efficacy
Antibacterial (tuberculostatic)
  Disease
Tuberculosis [DS:H00342]
Comment
Hydrazide
Target
enoyl-[acyl-carrier-protein] reductase (NADH) [KO:K11611]
Interaction
Drug interaction
Structure map
map07216  Catecholamine transferase inhibitors
Other map
map00983  Drug metabolism - other enzymes
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J04 ANTIMYCOBACTERIALS
   J04A DRUGS FOR TREATMENT OF TUBERCULOSIS
    J04AC Hydrazides
     J04AC01 Isoniazid
      D00346  Isoniazid (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antimycobacterials
  Antituberculars
   Isoniazid
    D00346  Isoniazid (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   622  Tuberculosis preparations
    6222  Isoniazids
     D00346  Isoniazid (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00346  Isoniazid
  D00346  Isoniazid tablets
  D00346  Isoniazid injection
Antiinfectives [br08350.html]
 Antibacterials
  D00346
BRITE hierarchy
Other DBs
CAS: 54-85-3
PubChem: 7847412
ChEBI: 6030
ChEMBL: CHEMBL64
DrugBank: DB00951
PDB-CCD: NIZ[PDBj]
LigandBox: D00346
NIKKAJI: J1.371D
LinkDB All DBs
KCF data Show

ATOM        10
            1   C8y C    22.4877  -16.7300
            2   C5a C    23.6995  -17.4291
            3   C8x C    21.2816  -17.4291
            4   C8x C    22.4877  -15.3316
            5   N1b N    24.9115  -16.7300
            6   O5a O    23.6995  -18.8275
            7   C8x C    20.0638  -16.7300
            8   C8x C    21.2816  -14.6266
            9   N1a N    26.1293  -17.4291
            10  N5x N    20.0638  -15.3316
BOND        10
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 2
            8     5   9 1
            9     7  10 2
            10    8  10 1

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