KEGG   DRUG: Zafirlukast
Entry
D00411                      Drug                                   
Name
Zafirlukast (JAN/USAN/INN);
Accolate (TN)
Product
ACCOLATE (Strides Pharma Science Limited), ZAFIRLUKAST (AvKARE), ZAFIRLUKAST (Bryant Ranch Prepack), ZAFIRLUKAST (Par Pharmaceutical), ZAFIRLUKAST (Strides Pharma Science Limited)
  Generic
ZAFIRLUKAST (American Health Packaging), ZAFIRLUKAST (Aurobindo Pharma Limited), ZAFIRLUKAST (Bryant Ranch Prepack), ZAFIRLUKAST (Camber Pharmaceuticals), ZAFIRLUKAST (Dr. Reddys Laboratories Limited)
Formula
C31H33N3O6S
Exact mass
575.2090
Mol weight
575.68
Structure
Simcomp
Class
Anti-allergic agent
 DG01541  Cysteinyl leukotriene receptor antagonist
Remark
Same as: C07206
ATC code: R03DC01
Product: D00411<US>
Efficacy
Antiasthmatic, Leukotriene receptor antagonist
  Disease
Asthma [DS:H00079]
Target
CYSLTR1 [HSA:10800] [KO:K04322]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07034  Eicosanoids
map07228  Eicosanoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03D OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
    R03DC Leukotriene receptor antagonists
     R03DC01 Zafirlukast
      D00411  Zafirlukast (JAN/USAN/INN) <US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Antileukotrienes
   Zafirlukast
    D00411  Zafirlukast (JAN/USAN/INN)
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01541  Cysteinyl leukotriene receptor antagonist
   D00411  Zafirlukast
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Cysteinyl leukotriene
    CYSLTR1
     D00411  Zafirlukast (JAN/USAN/INN) <US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00411
Other DBs
CAS: 107753-78-6
PubChem: 7847477
ChEBI: 10100
PDB-CCD: ZLK[PDBj]
LigandBox: D00411
NIKKAJI: J322.324H
LinkDB
KCF data

ATOM        41
            1   C8y C    26.8135  -18.7539
            2   C8y C    25.4863  -18.3350
            3   C8y C    26.8200  -20.1521
            4   C8x C    28.0184  -18.0581
            5   C1b C    24.2816  -17.6329
            6   C8x C    24.6745  -19.4626
            7   N4y N    25.4992  -20.5900
            8   C8x C    28.0248  -20.8413
            9   C8y C    29.2295  -18.7539
            10  C8y C    23.0702  -18.3287
            11  C1a C    25.0803  -21.9303
            12  C8x C    29.2295  -20.1455
            13  N1b N    30.4345  -18.0452
            14  C8y C    21.8526  -17.6200
            15  C8x C    23.0702  -19.7268
            16  C7a C    31.6522  -18.7474
            17  C8x C    20.6413  -18.3221
            18  O2a O    21.8589  -16.2218
            19  C8x C    21.8526  -20.4226
            20  O7a O    32.8635  -18.0387
            21  O6a O    31.6522  -20.1521
            22  C8y C    20.6413  -19.7268
            23  C1a C    20.6413  -15.5195
            24  C1y C    34.0811  -18.7474
            25  C5a C    19.4236  -20.4226
            26  C1x C    34.2356  -20.1455
            27  C1x C    35.3696  -18.1805
            28  N1b N    18.2123  -19.7268
            29  O5a O    19.4236  -21.8271
            30  C1x C    35.6080  -20.4355
            31  C1x C    36.3038  -19.2179
            32  S4a S    17.0010  -20.4226
            33  C8y C    15.7962  -19.7268
            34  O3c O    16.0023  -21.4213
            35  O3c O    17.9931  -21.4213
            36  C8y C    15.7962  -18.3221
            37  C8x C    14.5849  -20.4226
            38  C8x C    14.5849  -17.6200
            39  C1a C    17.0075  -17.6200
            40  C8x C    13.3673  -19.7268
            41  C8x C    13.3673  -18.3221
BOND        45
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    7  11 1
            11    8  12 2
            12    9  13 1
            13   10  14 1
            14   10  15 2
            15   13  16 1
            16   14  17 2
            17   14  18 1
            18   15  19 1
            19   16  20 1
            20   16  21 2
            21   17  22 1
            22   18  23 1
            23   20  24 1
            24   22  25 1
            25   24  26 1
            26   24  27 1
            27   25  28 1
            28   25  29 2
            29   26  30 1
            30   27  31 1
            31   28  32 1
            32   32  33 1
            33   32  34 2
            34   32  35 2
            35   33  36 1
            36   33  37 2
            37   36  38 2
            38   36  39 1
            39   37  40 1
            40   38  41 1
            41    6   7 1
            42    9  12 1
            43   19  22 2
            44   30  31 1
            45   40  41 2

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