KEGG   DRUG: Mitotane
Entry
D00420                      Drug                                   
Name
Mitotane (JAN/USP/INN);
Lysodren (TN)
Product
LYSODREN (HRA Pharma Rare Diseases)
Formula
C14H10Cl4
Exact mass
317.9537
Mol weight
320.03
Structure
Simcomp
Remark
Therapeutic category: 2499
ATC code: L01XX23
Product: D00420<JP/US>
Efficacy
Antineoplastic, Steroid biosynthesis inhibitor
  Disease
Adrenal cortical carcinoma [DS:H00033]
Target
CYP17A1 [HSA:1586] [KO:K00512]
  Pathway
hsa00140  Steroid hormone biosynthesis
hsa04934  Cushing syndrome
  Network
nt06310  CRH-ACTH-cortisol signaling
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XX Other antineoplastic agents
     L01XX23 Mitotane
      D00420  Mitotane (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Antineoplastics, Other
   Mitotane
    D00420  Mitotane (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2499  Others
     D00420  Mitotane (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Cytochrome P450
    CYP17A1
     D00420  Mitotane (JAN/USP/INN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00420
Other DBs
CAS: 53-19-0
PubChem: 7847486
ChEBI: 6954
LigandBox: D00420
NIKKAJI: J1.366H
LinkDB
KCF data

ATOM        18
            1   C8x C     8.6800  -15.2600
            2   C8x C     8.6800  -16.6600
            3   C8x C     9.8924  -17.3600
            4   C8x C    11.1049  -16.6600
            5   C8y C    11.1049  -15.2600
            6   C8y C     9.8924  -14.5600
            7   C8x C    13.5297  -16.6600
            8   C8y C    13.5297  -15.2600
            9   C1c C    12.3173  -14.5600
            10  C8x C    14.7422  -17.3600
            11  C8y C    15.9546  -16.6600
            12  C8x C    15.9546  -15.2600
            13  C8x C    14.7422  -14.5600
            14  X   Cl    9.8924  -13.1602
            15  C1c C    12.3173  -13.1600
            16  X   Cl   13.5318  -12.4588
            17  X   Cl   11.1069  -12.4612
            18  X   Cl   17.1711  -17.3623
BOND        19
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    6  14 1
            16    9  15 1
            17   15  16 1
            18   15  17 1
            19   11  18 1

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