KEGG   DRUG: Nabumetone
Entry
D00425                      Drug                                   

Name
Nabumetone (JP17/USP/INN);
Relafen (TN)
Product
  Generic
NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Eon Labs), NABUMETONE (PD-Rx Pharmaceuticals), NABUMETONE (Proficient Rx LP), NABUMETONE (St. Mary's Medical Park Pharmacy), NABUMETONE (A-S Medication Solutions), NABUMETONE (A-S Medication Solutions), NABUMETONE (A-S Medication Solutions), NABUMETONE (Actavis Pharma), NABUMETONE (American Health Packaging), RELAFEN (BLUCREST PHARMACEUTICALS LLC), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), RELAFEN DS (Carwin Pharmaceutical Associates), NABUMETONE (Cipla USA), NABUMETONE (DIRECT RX), NABUMETONE (DIRECT RX), NABUMETONE (Denton Pharma), NABUMETONE (Denton Pharma), NABUMETONE (Denton Pharma), NABUMETONE (Direct_Rx), NABUMETONE (Direct_Rx), NABUMETONE (Direct_Rx), NABUMETONE (Exelan Pharmaceuticals), NABUMETONE (Glenmark Pharmaceuticals), NABUMETONE (Impax Generics), NABUMETONE (LGM Pharma Solutions), NABUMETONE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), NABUMETONE (Lupin Pharmaceuticals), NABUMETONE (Medsource Pharmaceuticals), NABUMETONE (Medsource Pharmaceuticals), NABUMETONE (Nexgen Pharma), NABUMETONE (NuCare Pharmaceuticals), NABUMETONE (NuCare Pharmaceuticals), NABUMETONE (NuCare Pharmaceuticals), NABUMETONE (NuCare Pharmaceuticals), NABUMETONE (PD-Rx Pharmaceuticals), NABUMETONE (PD-Rx Pharmaceuticals), NABUMETONE (PD-Rx Pharmaceuticals), NABUMETONE (PD-Rx Pharmaceuticals), NABUMETONE (Preferred Pharmaceuticals), NABUMETONE (Preferred Pharmaceuticals), NABUMETONE (Preferred Pharmaceuticals), NABUMETONE (Preferred Pharmaceuticals), NABUMETONE (Preferred Pharmaceuticals), NABUMETONE (Proficient Rx LP), NABUMETONE (Proficient Rx LP), NABUMETONE (Proficient Rx LP), NABUMETONE (Proficient Rx LP), NABUMETONE (Proficient Rx LP), NABUMETONE (Quality Care Products), NABUMETONE (Quality Care Products), NABUMETONE (Quality Care Products), NABUMETONE (Quality Care Products), NABUMETONE (REMEDYREPACK), NABUMETONE (ScieGen Pharmaceuticals), NABUMETONE (St. Mary's Medical Park Pharmacy), NABUMETONE (St. Mary's Medical Park Pharmacy), NABUMETONE (St. Mary's Medical Park Pharmacy), NABUMETONE (St. Mary's Medical Park Pharmacy), NABUMETONE (St. Mary's Medical Park Pharmacy), NABUMETONE (St. Mary's Medical Park Pharmacy), NABUMETONE (St.Mary's Medical Park Pharmacy), NABUMETONE (Unit Dose Services), NABUMETONE (Westminster Pharmaceuticals), NABUMETONE (direct rx), NABUMETONE (medsource pharmaceuticals)
Formula
C15H16O2
Exact mass
228.115
Mol weight
228.2863
Structure
Class
Anti-inflammatory
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01922  Selective COX2 inhibitor
 DG01922  Selective COX2 inhibitor
Remark
Therapeutic category: 1149
ATC code: M01AX01
Product: D00425<JP/US>
Efficacy
Analgesic, Anti-inflammatory, COX inhibitor
Target
PTGS2 (COX2) [HSA:5743] [KO:K11987]
PTGS1 (COX1) [HSA:5742] [KO:K00509]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Structure map
map07114  Naphthalene family
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AX Other antiinflammatory and antirheumatic agents, non-steroids
     M01AX01 Nabumetone
      D00425  Nabumetone (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Nabumetone
    D00425  Nabumetone (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00425  Nabumetone (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00425  Nabumetone (JP17/USP/INN) <JP/US>
    PTGS2 (COX2)
     D00425  Nabumetone (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00425  Nabumetone
  D00425  Nabumetone tablets
Other DBs
CAS: 42924-53-8
PubChem: 7847491
ChEBI: 7443
ChEMBL: CHEMBL1070
DrugBank: DB00461
PDB-CCD: NBO[PDBj]
LigandBox: D00425
NIKKAJI: J16.442I
LinkDB
KCF data

ATOM        17
            1   C8y C    27.8600  -24.7800
            2   C8y C    27.8600  -26.1800
            3   C8x C    29.0500  -24.0800
            4   C8x C    26.6000  -24.0800
            5   C8x C    26.6000  -26.8800
            6   C8x C    29.0500  -26.8800
            7   C8y C    30.2400  -24.7800
            8   C8x C    25.4100  -24.7800
            9   C8y C    25.4100  -26.1800
            10  C8x C    30.2400  -26.1800
            11  C1b C    31.4300  -24.0800
            12  O2a O    24.2200  -26.8800
            13  C1b C    32.6200  -24.7800
            14  C1a C    22.9600  -26.1800
            15  C5a C    33.8100  -24.0800
            16  C1a C    35.0700  -24.7800
            17  O5a O    33.8100  -22.6800
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     6  10 2
            10    7  11 1
            11    9  12 1
            12   11  13 1
            13   12  14 1
            14   13  15 1
            15   15  16 1
            16   15  17 2
            17    7  10 1
            18    8   9 2

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