KEGG   DRUG: Sulfadiazine, silver
Entry
D00433                      Drug                                   
Name
Sulfadiazine, silver (USP);
Sulfadiazine silver (JP18);
Silvadene (TN)
Product
  Generic
Formula
C10H9N4O2S. Ag
Exact mass
355.9497
Mol weight
357.1373
Structure
Simcomp
Class
Antibacterial
 DG01787  Sulfonamide antibacterial
  DG01785  Intermediate-acting sulfonamide
Remark
Therapeutic category: 2633
ATC code: D06BA01 J01EC02
Chemical structure group: DG00599
Product (DG00599): D00587<US> D00433<JP/US>
Efficacy
Antibacterial (topical), Folic acid biosynthesis inhibitor
Comment
Sulfonamide
Target
dihydropteroate synthase [KO:K00796]
  Pathway
ko00790  Folate biosynthesis
Interaction
Structure map
map07016  Sulfonamide derivatives - sulfa drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06B CHEMOTHERAPEUTICS FOR TOPICAL USE
    D06BA Sulfonamides
     D06BA01 Silver sulfadiazine
      D00433  Sulfadiazine, silver (USP) <JP/US>
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01E SULFONAMIDES AND TRIMETHOPRIM
    J01EC Intermediate-acting sulfonamides
     J01EC02 Sulfadiazine
      D00433  Sulfadiazine, silver (USP) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatological Agents, Other
   Wound Care Agents
    Silver Sulfadiazine
     D00433  Sulfadiazine, silver (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   263  Suppurative dermatosis agents
    2633  Sulfa drugs for external use
     D00433  Sulfadiazine, silver (USP); Sulfadiazine silver (JP18)
Drug groups [BR:br08330]
 Antibacterial
  DG01787  Sulfonamide antibacterial
   DG01785  Intermediate-acting sulfonamide
    DG00599  Sulfadiazine
     D00433  Sulfadiazine, silver
Antimicrobials [BR:br08307]
 Antibacterials
  Folic acid biosynthesis inhibitor
   Intermediate-acting sulfonamide
    D00433  Sulfadiazine, silver (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00433  Sulfadiazine silver
Drug groups [BR:br08330]
 Antibacterial
  DG01787  Sulfonamide antibacterial
   DG01785  Intermediate-acting sulfonamide
    DG00599  Sulfadiazine
Other DBs
CAS: 22199-08-2
PubChem: 7847499
ChEBI: 9142
LigandBox: D00433
NIKKAJI: J550.743J
LinkDB
KCF data

ATOM        18
            1   C8y C    24.2684  -17.0689
            2   S4a S    25.4787  -16.3673
            3   C8x C    24.2741  -18.4665
            4   C8x C    23.0638  -16.3673
            5   N1b N    26.6891  -17.0689 #-
            6   O3c O    26.4610  -15.3792
            7   O3c O    24.4788  -15.3792
            8   C8x C    23.0638  -19.1682
            9   C8x C    21.8534  -17.0572
            10  C8y C    27.9052  -16.3673
            11  C8y C    21.8477  -18.4665
            12  N5x N    27.8995  -14.9639
            13  N5x N    29.1097  -17.0689
            14  N1a N    20.6373  -19.1622
            15  C8x C    29.1097  -14.2623
            16  C8x C    30.3200  -16.3732
            17  C8x C    30.3259  -14.9639
            18  Z   Ag   26.6605  -18.9740 #+
BOND        18
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     2   7 2
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    8  11 2
            11   10  12 2
            12   10  13 1
            13   11  14 1
            14   12  15 1
            15   13  16 2
            16   15  17 2
            17    9  11 1
            18   16  17 1

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