KEGG   DRUG: Promethazine
Entry
D00494                      Drug                                   

Name
Promethazine (JAN/INN)
Formula
C17H20N2S
Exact mass
284.1347
Mol weight
284.4191
Structure
Simcomp
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
Same as: C07404
ATC code: D04AA10 R06AD02
Chemical structure group: DG00385
Product (DG00385): D00480<JP/US> D03290<JP> D08768<JP>
Product (mixture): D11852<US> D11853<US>
Efficacy
Antiallergic, H1 receptor antagonist
Comment
Phenothiazine derivative
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Structure map
map07028  Antipsychotics
map07029  Antipsychotics - phenothiazines
map07032  Hypnotics
map07212  Histamine H1 receptor antagonists
map07213  Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AA Antihistamines for topical use
     D04AA10 Promethazine
      D00494  Promethazine (JAN/INN)
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AD Phenothiazine derivatives
     R06AD02 Promethazine
      D00494  Promethazine (JAN/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Promethazine
    D00494  Promethazine (JAN/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Promethazine
    D00494  Promethazine (JAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D00494  Promethazine (JAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00494
Other DBs
CAS: 60-87-7
PubChem: 7847560
ChEBI: 8461
ChEMBL: CHEMBL643
DrugBank: DB01069
LigandBox: D00494
NIKKAJI: J4.809G
LinkDB
KCF data

ATOM        20
            1   N1y N    25.3291  -19.1045
            2   C8y C    26.5689  -19.8030
            3   C8y C    24.1359  -19.8030
            4   C1b C    25.3291  -17.6902
            5   C8y C    26.5689  -21.2116
            6   C8x C    27.7621  -19.1045
            7   C8y C    24.1359  -21.2116
            8   C8x C    22.9369  -19.1045
            9   C1c C    26.5340  -17.0033
            10  S2x S    25.3291  -21.9041
            11  C8x C    27.7621  -21.9041
            12  C8x C    28.9670  -19.8030
            13  C8x C    22.9369  -21.9041
            14  C8x C    21.6971  -19.8030
            15  N1c N    26.5340  -15.6820
            16  C1a C    27.7272  -17.6902
            17  C8x C    28.9670  -21.2116
            18  C8x C    21.6971  -21.2116
            19  C1a C    25.1953  -14.9079
            20  C1a C    27.6690  -14.9428
BOND        22
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 1
            11    6  12 2
            12    7  13 1
            13    8  14 2
            14    9  15 1
            15    9  16 1
            16   11  17 2
            17   13  18 2
            18   15  19 1
            19   15  20 1
            20    7  10 1
            21   12  17 1
            22   14  18 1

» Japanese version   » Back

KEGG   DRUG: Promethazine hydrochloride
Entry
D00480                      Drug                                   

Name
Promethazine hydrochloride (JP18/USP);
Phenergan (TN);
Promethegan (TN)
Product
  Generic
PROMETHAZINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), PROMETHAZINE (PharmPak), PROMETHAZINE HCI (HF Acquisition Co. LLC), PROMETHAZINE HCI (HF Acquisition Co. LLC), PROMETHAZINE HYDROCHLORIDE (A-S Medication Solutions), PROMETHAZINE HYDROCHLORIDE (A-S Medication Solutions), PROMETHAZINE HYDROCHLORIDE (A-S Medication Solutions), PROMETHAZINE HYDROCHLORIDE (A-S Medication Solutions), PHENADOZ (A-S Medication Solutions), PROMETHAZINE HYDROCHLORIDE (A-S Medication Solutions), PROMETHAZINE HYDROCHLORIDE (A-S Medication Solutions), PROMETHAZINE HYDROCHLORIDE (A-S Medication Solutions), PROMETHAZINE HYDROCHLORIDE (A-S Medication Solutions), PROMETHAZINE HYDROCHLORIDE (A-S Medication Solutions), PROMETHAZINE HYDROCHLORIDE (A-S Medication Solutions), PROMETHAZINE HYDROCHLORIDE (A-S Medication Solutions), PHENADOZ (A-S Medication Solutions), PROMETHAZINE HYDROCHLORIDE (Actavis Pharma), PHENADOZ (Actavis Pharma), PROMETHAZINE HYDROCHLORIDE (American Health Packaging), PROMETHAZINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), PROMETHAZINE HYDROCHLORIDE (BluePoint Laboratories), PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack), PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack), PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack), PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack), PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack), PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack), PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack), PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack), PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack), PROMETHAZINE HYDROCHLORIDE (Cadila Healthcare Limited), PROMETHAZINE HYDROCHLORIDE (Cardinal Health), PROMETHAZINE HYDROCHLORIDE (Cardinal Health), PROMETHAZINE HYDROCHLORIDE (Clinical Solutions Wholesale), PROMETHAZINE HYDROCHLORIDE (Contract Pharmacy Services-PA), PROMETHEGAN (Cosette Pharmaceuticals), PROMETHEGAN (Cosette Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (DIERCT RX), PROMETHAZINE HYDROCHLORIDE (DIRECT RX), PROMETHAZINE HYDROCHLORIDE (DIRECT RX), PROMETHAZINE HYDROCHLORIDE (DIRECT RX), PROMETHAZINE HYDROCHLORIDE (DIRECT RX), PROMETHAZINE HYDROCHLORIDE (Denton Pharma), PROMETHAZINE HYDROCHLORIDE (Denton Pharma), PROMETHAZINE HYDROCHLORIDE (Denton Pharma), PROMETHAZINE HYDROCHLORIDE (Denton Pharma), PROMETHAZINE HYDROCHLORIDE (Direct Rx), PROMETHAZINE HYDROCHLORIDE (Direct_Rx), PROMETHAZINE HYDROCHLORIDE (Direct_Rx), PROMETHAZINE HYDROCHLORIDE (General Injectables & Vaccines), PROMETHAZINE HYDROCHLORIDE (General Injectables & Vaccines), PROMETHAZINE HYDROCHLORIDE (General Injectables and Vaccines), PROMETHAZINE HYDROCHLORIDE (Golden State Medical Supply), PROMETHAZINE HYDROCHLORIDE (Hi-Tech Pharmacal), PROMETHAZINE HYDROCHLORIDE (KVK-Tech), PROMETHAZINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), PROMETHAZINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), PROMETHAZINE HYDROCHLORIDE (Major Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Marlex Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (McKesson Corporation dba SKY Packaging), PROMETHAZINE HYDROCHLORIDE (Medical Purchasing Solutions), PROMETHAZINE HYDROCHLORIDE (Morton Grove Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (NCS HealthCare of KY), PROMETHAZINE HYDROCHLORIDE (Nostrum Laboratories), PROMETHAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROMETHEGAN (PD-Rx Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROMETHAZINE (PD-Rx Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Par Pharmaceutical), PROMETHAZINE HYDROCHLORIDE (Perrigo New York), PROMETHAZINE HYDROCHLORIDE (Pharmaceutical Associates), PROMETHAZINE HYDROCHLORIDE (Preferred Pharmaceutical), PROMETHAZINE HYDROCHLORIDE (Preferred Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Preferred Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Proficient Rx LP), PROMETHAZINE HYDROCHLORIDE (Proficient Rx LP), PROMETHAZINE HYDROCHLORIDE (Proficient Rx LP), PROMETHAZINE HYDROCHLORIDE (Proficient Rx LP), PROMETHAZINE HYDROCHLORIDE (QPharma), PHENERGAN (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (RPK Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (RedPharm Drug), PROMETHAZINE HYDROCHLORIDE (RedPharm Drug), PROMETHAZINE HYDROCHLORIDE (RedPharm Drug), PROMETHAZINE HYDROCHLORIDE (RedPharm Drug), PROMETHAZINE HYDROCHLORIDE (Sandoz), PROMETHAZINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), PROMETHAZINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), PROMETHAZINE HYDROCHLORIDE (Strides Pharma Science Limited), PROMETHAZINE HYDROCHLORIDE (Taro Pharmaceuticals U.S.A.), PROMETHAZINE HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.), PROMETHAZINE HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.), PHENERGAN (West-Ward Pharmaceuticals Corp.), PROMETHAZINE HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.), PHENERGAN (West-Ward Pharmaceuticals Corp.), PROMETHAZINE HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.), PROMETHAZINE HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.), PROMETHAZINE HCL (Wockhardt USA LLC.), PROMETHAZINE HYDROCHLORIDE (X-GEN Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (X-GEN Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), PROMETHAZINE HYDROCHLORIDE (medsource pharmaceuticals)
Formula
C17H20N2S. HCl
Exact mass
320.1114
Mol weight
320.88
Structure
Simcomp
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
Therapeutic category: 4413
ATC code: D04AA10 R06AD02
Chemical structure group: DG00385
Product (DG00385): D00480<JP/US> D03290<JP> D08768<JP>
Product (mixture): D11852<US> D11853<US> D11854<US>
Efficacy
Antiallergic, Anti-emetic, Antiparkinsonian, H1 receptor antagonist
  Disease
Perennial and seasonal allergic rhinitis [DS:H01360]
Comment
Phenothiazine derivative
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Structure map
map07028  Antipsychotics
map07029  Antipsychotics - phenothiazines
map07032  Hypnotics
map07212  Histamine H1 receptor antagonists
map07213  Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AA Antihistamines for topical use
     D04AA10 Promethazine
      D00480  Promethazine hydrochloride (JP18/USP) <JP/US>
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AD Phenothiazine derivatives
     R06AD02 Promethazine
      D00480  Promethazine hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Promethazine
    D00480  Promethazine hydrochloride (JP18/USP)
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Histamine (H1) Receptor Antagonists, Sedating
    Promethazine
     D00480  Promethazine hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   441  Antihistamines
    4413  Phenothiazines
     D00480  Promethazine hydrochloride (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Promethazine
    D00480  Promethazine hydrochloride (JP18/USP)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Promethazine
    D00480  Promethazine hydrochloride (JP18/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D00480  Promethazine hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00480  Promethazine hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00480
Other DBs
CAS: 58-33-3
PubChem: 7847546
ChEBI: 8462
ChEMBL: CHEMBL1200750
DrugBank: DB01069
LigandBox: D00480
NIKKAJI: J371.970G
LinkDB
KCF data

ATOM        21
            1   N1y N    24.1512  -19.0928
            2   C8y C    25.3914  -19.7915
            3   C8y C    22.9575  -19.7915
            4   C1b C    24.1512  -17.6779
            5   C8y C    25.3914  -21.1947
            6   C8x C    26.5851  -19.0928
            7   C8y C    22.9575  -21.1947
            8   C8x C    21.7580  -19.0928
            9   C1c C    25.3565  -16.9850
            10  S2x S    24.1512  -21.8934
            11  C8x C    26.5851  -21.8934
            12  C8x C    27.7904  -19.7915
            13  C8x C    21.7580  -21.8934
            14  C8x C    20.5179  -19.7915
            15  N1c N    25.3565  -15.6691
            16  C1a C    26.5442  -17.6779
            17  C8x C    27.7904  -21.1947
            18  C8x C    20.5179  -21.1947
            19  C1a C    24.0173  -14.8947
            20  C1a C    26.4919  -14.9296
            21  X   Cl   30.1777  -19.5178
BOND        22
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 1
            11    6  12 2
            12    7  13 1
            13    8  14 2
            14    9  15 1
            15    9  16 1
            16   11  17 2
            17   13  18 2
            18   15  19 1
            19   15  20 1
            20    7  10 1
            21   12  17 1
            22   14  18 1

» Japanese version   » Back

KEGG   DRUG: Promethazine teoclate
Entry
D01242                      Drug                                   

Name
Promethazine teoclate (JAN/INN);
Avomine (TN)
Formula
C17H20N2S. C7H7ClN4O2
Exact mass
498.1605
Mol weight
499.0282
Structure
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
ATC code: D04AA10 R06AD02
Chemical structure group: DG00385
Product (DG00385): D00480<JP/US> D03290<JP> D08768<JP>
Efficacy
Antiallergic, H1 receptor antagonist
Comment
Phenothiazine derivative
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Structure map
map07028  Antipsychotics
map07029  Antipsychotics - phenothiazines
map07032  Hypnotics
map07212  Histamine H1 receptor antagonists
map07213  Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AA Antihistamines for topical use
     D04AA10 Promethazine
      D01242  Promethazine teoclate (JAN/INN)
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AD Phenothiazine derivatives
     R06AD02 Promethazine
      D01242  Promethazine teoclate (JAN/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for nervous and sensory systems
  06 Antivertigo drugs (incl. motion/morning sickness remedies)
   D01242  Promethazine teoclate (JAN/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Promethazine
    D01242  Promethazine teoclate (JAN/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Promethazine
    D01242  Promethazine teoclate (JAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D01242  Promethazine teoclate (JAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01242
Other DBs
CAS: 17693-51-5
PubChem: 7848305
ChEBI: 32059
ChEMBL: CHEMBL3833361
DrugBank: DB01069
LigandBox: D01242
NIKKAJI: J290.364D
LinkDB
KCF data

ATOM        34
            1   C8y C    30.2443  -17.6964
            2   C8y C    30.2506  -19.0899
            3   N5x N    28.9273  -19.5264
            4   C8y C    28.1034  -18.4026
            5   N4x N    28.9172  -17.2718
            6   C8y C    32.6628  -19.0943
            7   N4y N    31.4535  -19.7945
            8   C8y C    31.4501  -16.9997
            9   N4y N    32.6611  -17.6969
            10  C1a C    33.8790  -16.9939
            11  O5x O    31.4605  -15.5937
            12  O5x O    33.8790  -19.7875
            13  C1a C    31.4605  -21.1947
            14  X   Cl   26.7081  -18.4013
            15  C8y C    21.7358  -19.8545
            16  C8y C    21.7987  -21.2547
            17  C8x C    22.9378  -21.9610
            18  C8x C    24.2240  -21.2670
            19  C8x C    24.2309  -19.8667
            20  C8x C    22.9520  -19.1604
            21  C8y C    19.3172  -19.8474
            22  C8y C    19.3100  -21.2476
            23  S2x S    20.5191  -21.9539
            24  N1y N    20.5334  -19.1533
            25  C8x C    16.8986  -19.8474
            26  C8x C    16.8986  -21.2476
            27  C8x C    18.1141  -21.9477
            28  C8x C    18.1141  -19.1473
            29  C1b C    20.5193  -17.7470
            30  C1c C    21.7287  -17.0398
            31  C1a C    22.9379  -17.7398
            32  N1c N    21.7217  -15.6395
            33  C1a C    22.9310  -14.9324
            34  C1a C    20.5053  -14.9394
BOND        37
            1     7   2 1
            2     1   8 1
            3     8   9 1
            4     9   6 1
            5     3   4 2
            6     9  10 1
            7     4   5 1
            8     8  11 2
            9     5   1 1
            10    6  12 2
            11    7  13 1
            12    4  14 1
            13    1   2 2
            14    2   3 1
            15    6   7 1
            16   15  16 2
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   19  20 2
            21   20  15 1
            22   21  22 2
            23   22  23 1
            24   23  16 1
            25   15  24 1
            26   24  21 1
            27   25  26 1
            28   26  27 2
            29   27  22 1
            30   21  28 1
            31   28  25 2
            32   24  29 1
            33   29  30 1
            34   30  31 1
            35   30  32 1
            36   32  33 1
            37   32  34 1

» Japanese version   » Back

KEGG   DRUG: Promethazine methylenedisalicylate
Entry
D03290                      Drug                                   

Name
Promethazine methylenedisalicylate (JAN);
Pyrethia (TN)
Formula
(C17H20N2S)2. C15H12O6
Exact mass
856.3328
Mol weight
857.0904
Structure
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
Therapeutic category: 1169 4413
ATC code: D04AA10 R06AD02
Chemical structure group: DG00385
Product (DG00385): D00480<JP/US> D03290<JP> D08768<JP>
Product (mixture): D04046<JP>
Efficacy
Antiallergic, Antiparkinsonian, H1 receptor antagonist
Comment
Phenothiazine derivative
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Structure map
map07028  Antipsychotics
map07029  Antipsychotics - phenothiazines
map07032  Hypnotics
map07212  Histamine H1 receptor antagonists
map07213  Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AA Antihistamines for topical use
     D04AA10 Promethazine
      D03290  Promethazine methylenedisalicylate (JAN) <JP>
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AD Phenothiazine derivatives
     R06AD02 Promethazine
      D03290  Promethazine methylenedisalicylate (JAN) <JP>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Histamine (H1) Receptor Antagonists, Sedating
    Promethazine
     D03290  Promethazine methylenedisalicylate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   116  Antiparkinsonian agents
    1169  Others
     D03290  Promethazine methylenedisalicylate (JAN)
 4  Agents affecting cellular function
  44  Allergic agents
   441  Antihistamines
    4413  Phenothiazines
     D03290  Promethazine methylenedisalicylate (JAN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Promethazine
    D03290  Promethazine methylenedisalicylate (JAN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Promethazine
    D03290  Promethazine methylenedisalicylate (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D03290  Promethazine methylenedisalicylate (JAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D03290
Other DBs
PubChem: 17397441
DrugBank: DB01069
LigandBox: D03290
LinkDB
KCF data

ATOM        61
            1   N1y N    14.0591  -13.7145
            2   C8y C    15.2989  -14.4130
            3   C8y C    12.8659  -14.4130
            4   C1b C    14.0591  -12.3002
            5   C8y C    15.2989  -15.8216
            6   C8x C    16.4921  -13.7145
            7   C8y C    12.8659  -15.8216
            8   C8x C    11.6669  -13.7145
            9   C1c C    15.2640  -11.6133
            10  S2x S    14.0591  -16.5141
            11  C8x C    16.4921  -16.5141
            12  C8x C    17.6970  -14.4130
            13  C8x C    11.6669  -16.5141
            14  C8x C    10.4271  -14.4130
            15  N1c N    15.2640  -10.2920
            16  C1a C    16.4572  -12.3002
            17  C8x C    17.6970  -15.8216
            18  C8x C    10.4271  -15.8216
            19  C1a C    13.9253   -9.5179
            20  C1a C    16.3990   -9.5528
            21  C8y C    22.5400  -12.9500
            22  C8y C    22.5400  -14.3500
            23  C8x C    23.7524  -15.0500
            24  C8x C    24.9649  -14.3500
            25  C8y C    24.9649  -12.9500
            26  C8x C    23.7524  -12.2500
            27  C8x C    27.3897  -14.3500
            28  C8y C    27.3897  -12.9500
            29  C1b C    26.1773  -12.2500
            30  C8x C    28.6022  -15.0500
            31  C8y C    29.8146  -14.3500
            32  C8y C    29.8146  -12.9500
            33  C8x C    28.6022  -12.2500
            34  C6a C    21.3276  -12.2500
            35  O6a O    20.1321  -12.9404
            36  O6a O    21.3275  -10.8502
            37  O1a O    21.3276  -15.0500
            38  C6a C    31.0311  -12.2477
            39  O6a O    32.2286  -12.9392
            40  O6a O    31.0311  -10.8502
            41  O1a O    31.0311  -15.0523
            42  N1y N    14.0591  -13.7145
            43  C8y C    15.2989  -14.4130
            44  C8y C    15.2989  -15.8216
            45  S2x S    14.0591  -16.5141
            46  C8y C    12.8659  -15.8216
            47  C8y C    12.8659  -14.4130
            48  C8x C    11.6669  -13.7145
            49  C8x C    10.4271  -14.4130
            50  C8x C    10.4271  -15.8216
            51  C8x C    11.6669  -16.5141
            52  C8x C    16.4921  -16.5141
            53  C8x C    17.6970  -15.8216
            54  C8x C    17.6970  -14.4130
            55  C8x C    16.4921  -13.7145
            56  C1b C    14.0591  -12.3002
            57  C1c C    15.2640  -11.6133
            58  N1c N    15.2640  -10.2920
            59  C1a C    13.9253   -9.5179
            60  C1a C    16.3990   -9.5528
            61  C1a C    16.4572  -12.3002
BOND        66
            1    21  22 2
            2    22  23 1
            3    23  24 2
            4    24  25 1
            5    25  26 2
            6    21  26 1
            7    27  28 1
            8    28  29 1
            9    25  29 1
            10   27  30 2
            11   30  31 1
            12   31  32 2
            13   32  33 1
            14   28  33 2
            15   21  34 1
            16   34  35 1
            17   34  36 2
            18   22  37 1
            19   32  38 1
            20   38  39 1
            21   38  40 2
            22   31  41 1
            23    1   2 1
            24    1   3 1
            25    1   4 1
            26    2   5 2
            27    2   6 1
            28    3   7 2
            29    3   8 1
            30    4   9 1
            31    5  10 1
            32    5  11 1
            33    6  12 2
            34    7  13 1
            35    8  14 2
            36    9  15 1
            37    9  16 1
            38   11  17 2
            39   13  18 2
            40   15  19 1
            41   15  20 1
            42    7  10 1
            43   12  17 1
            44   14  18 1
            45   42  43 1
            46   42  47 1
            47   42  56 1
            48   43  44 2
            49   43  55 1
            50   47  46 2
            51   47  48 1
            52   56  57 1
            53   44  45 1
            54   44  52 1
            55   55  54 2
            56   46  51 1
            57   48  49 2
            58   57  58 1
            59   57  61 1
            60   52  53 2
            61   51  50 2
            62   58  59 1
            63   58  60 1
            64   46  45 1
            65   54  53 1
            66   49  50 1
BRACKET     1    10.1500  -17.1500   10.1500   -8.6800
            1    18.3400   -8.6800   18.3400  -17.1500
            1  2
 ORIGINAL  1    1   2   5  10   7   3   8  14  18  13  11  17  12   6   4   9
            1   15  19  20  16
 REPEAT    1   42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57
            1   58  59  60  61

» Japanese version   » Back

KEGG   DRUG: Promethazine maleate
Entry
D08432                      Drug                                   

Name
Promethazine maleate;
Romergan (TN)
Formula
C17H20N2S. C4H4O4
Exact mass
400.1457
Mol weight
400.4913
Structure
Simcomp
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
ATC code: D04AA10 R06AD02
Chemical structure group: DG00385
Product (DG00385): D00480<JP/US> D03290<JP> D08768<JP>
Efficacy
Antiallergic, H1 receptor antagonist
Comment
Phenothiazine derivative
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Structure map
map07028  Antipsychotics
map07029  Antipsychotics - phenothiazines
map07032  Hypnotics
map07212  Histamine H1 receptor antagonists
map07213  Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AA Antihistamines for topical use
     D04AA10 Promethazine
      D08432  Promethazine maleate
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AD Phenothiazine derivatives
     R06AD02 Promethazine
      D08432  Promethazine maleate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D08432  Promethazine maleate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08432
Other DBs
CAS: 27059-74-1
PubChem: 96025118
LigandBox: D08432
NIKKAJI: J311.423F
LinkDB
KCF data

ATOM        28
            1   N1y N    19.2500  -18.6200
            2   C8y C    20.5100  -19.3200
            3   C8y C    18.0600  -19.3200
            4   C1b C    19.2500  -17.2200
            5   C8y C    20.5100  -20.7200
            6   C8x C    21.7000  -18.6200
            7   C8y C    18.0600  -20.7200
            8   C8x C    16.8700  -18.6200
            9   C1c C    20.4400  -16.5200
            10  S2x S    19.2500  -21.4200
            11  C8x C    21.7000  -21.4200
            12  C8x C    22.8900  -19.3200
            13  C8x C    16.8700  -21.4200
            14  C8x C    15.6100  -19.3200
            15  N1c N    20.4400  -15.1900
            16  C1a C    21.6300  -17.2200
            17  C8x C    22.8900  -20.7200
            18  C8x C    15.6100  -20.7200
            19  C1a C    19.1100  -14.4200
            20  C1a C    21.5600  -14.4200
            21  C6a C    28.2775  -18.1919
            22  O6a O    28.9624  -19.4129
            23  O6a O    30.3623  -19.4304
            24  C6a C    31.0773  -18.2268
            25  C2b C    30.3925  -17.0057
            26  C2b C    28.9926  -16.9883
            27  O6a O    32.4793  -18.1743
            28  O6a O    26.8802  -18.1745
BOND        29
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 1
            11    6  12 2
            12    7  13 1
            13    8  14 2
            14    9  15 1
            15    9  16 1
            16   11  17 2
            17   13  18 2
            18   15  19 1
            19   15  20 1
            20    7  10 1
            21   12  17 1
            22   14  18 1
            23   21  22 2
            24   23  24 1
            25   24  25 1
            26   25  26 2
            27   21  26 1
            28   24  27 2
            29   21  28 1

» Japanese version   » Back

KEGG   DRUG: Promethazine hibenzate
Entry
D08768                      Drug                                   

Name
Promethazine hibenzate;
Hiberna (TN)
Formula
C17H20N2S. C14H10O4
Exact mass
526.1926
Mol weight
526.6459
Structure
Simcomp
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
Therapeutic category: 4413
ATC code: D04AA10 R06AD02
Chemical structure group: DG00385
Product (DG00385): D00480<JP/US> D03290<JP> D08768<JP>
Efficacy
Antiallergic, Antiparkinsonian, H1 receptor antagonist
Comment
Phenothiazine derivative
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Structure map
map07028  Antipsychotics
map07029  Antipsychotics - phenothiazines
map07032  Hypnotics
map07212  Histamine H1 receptor antagonists
map07213  Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AA Antihistamines for topical use
     D04AA10 Promethazine
      D08768  Promethazine hibenzate <JP>
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AD Phenothiazine derivatives
     R06AD02 Promethazine
      D08768  Promethazine hibenzate <JP>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Histamine (H1) Receptor Antagonists, Sedating
    Promethazine
     D08768  Promethazine hibenzate
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   441  Antihistamines
    4413  Phenothiazines
     D08768  Promethazine hibenzate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D08768  Promethazine hibenzate <JP>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08768
Other DBs
PubChem: 96025451
LigandBox: D08768
LinkDB
KCF data

ATOM        38
            1   N1y N    13.3578  -16.8634
            2   C8y C    14.5975  -17.5618
            3   C8y C    12.1647  -17.5618
            4   C1b C    13.3578  -15.4492
            5   C8y C    14.5975  -18.9703
            6   C8x C    15.7906  -16.8634
            7   C8y C    12.1647  -18.9703
            8   C8x C    10.9658  -16.8634
            9   C1c C    14.5626  -14.7623
            10  S2x S    13.3578  -19.6627
            11  C8x C    15.7906  -19.6627
            12  C8x C    16.9954  -17.5618
            13  C8x C    10.9658  -19.6627
            14  C8x C     9.7261  -17.5618
            15  N1c N    14.5626  -13.4411
            16  C1a C    15.7557  -15.4492
            17  C8x C    16.9954  -18.9703
            18  C8x C     9.7261  -18.9703
            19  C1a C    13.2240  -12.6671
            20  C1a C    15.6975  -12.7020
            21  C8x C    19.1083  -17.5688
            22  C8x C    19.1083  -18.9687
            23  C8x C    20.3206  -19.6686
            24  C8x C    21.5330  -18.9687
            25  C8y C    21.5330  -17.5688
            26  C8y C    20.3206  -16.8689
            27  C8x C    23.9576  -18.9687
            28  C8y C    23.9576  -17.5688
            29  C5a C    22.7453  -16.8689
            30  C8x C    25.1700  -19.6686
            31  C8y C    26.3823  -18.9687
            32  C8x C    26.3823  -17.5688
            33  C8x C    25.1700  -16.8689
            34  O1a O    27.5987  -19.6709
            35  O5a O    22.7453  -15.4690
            36  C6a C    20.3206  -15.4692
            37  O6a O    19.0915  -14.7593
            38  O6a O    21.5161  -14.7788
BOND        41
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 1
            11    6  12 2
            12    7  13 1
            13    8  14 2
            14    9  15 1
            15    9  16 1
            16   11  17 2
            17   13  18 2
            18   15  19 1
            19   15  20 1
            20    7  10 1
            21   12  17 1
            22   14  18 1
            23   21  22 2
            24   22  23 1
            25   23  24 2
            26   24  25 1
            27   25  26 2
            28   21  26 1
            29   27  28 2
            30   28  29 1
            31   25  29 1
            32   27  30 1
            33   30  31 2
            34   31  32 1
            35   32  33 2
            36   28  33 1
            37   31  34 1
            38   29  35 2
            39   26  36 1
            40   36  37 2
            41   36  38 1

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