KEGG   DRUG: Isosorbide dinitrate
Entry
D00516                      Drug                                   
Name
Isosorbide dinitrate (JP18/USP/INN);
Dilatrate-sr (TN);
Isordil (TN)
Product
  Generic
Formula
C6H8N2O8
Exact mass
236.0281
Mol weight
236.1363
Structure
Simcomp
Class
Cardiovascular agent
 DG01657  Nitrovasodilator
Remark
Same as: C07456
Therapeutic category: 2171
ATC code: C01DA08 C05AE02
Chemical structure group: DG01270
Product (DG01270): D00516<JP/US> D00630<JP/US>
Product (mixture): D10209<US>
Efficacy
Vasodilator (coronary)
  Disease
Angina pectoris [DS:H01632]
Comment
Organic nitrate
Osmotic diuretics
Nitric oxide donor
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01D VASODILATORS USED IN CARDIAC DISEASES
    C01DA Organic nitrates
     C01DA08 Isosorbide dinitrate
      D00516  Isosorbide dinitrate (JP18/USP/INN) <JP/US>
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AE Muscle relaxants
     C05AE02 Isosorbide dinitrate
      D00516  Isosorbide dinitrate (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Vasodilators
   Direct-acting Arterial/Venous
    Isosorbide Dinitrate
     D00516  Isosorbide dinitrate (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   217  Vasodilators
    2171  Coronary dilators
     D00516  Isosorbide dinitrate (JP18/USP/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01657  Nitrovasodilator
   DG01270  Isosorbide nitrate
    D00516  Isosorbide dinitrate
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00516  Isosorbide dinitrate
  D00516  Isosorbide dinitrate tablets
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00516
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01657  Nitrovasodilator
   DG01270  Isosorbide nitrate
Other DBs
CAS: 87-33-2
PubChem: 7847582
ChEBI: 6061
LigandBox: D00516
NIKKAJI: J3.899G
LinkDB
KCF data

ATOM        16
            1   C1y C    20.6734  -17.3108
            2   C1y C    20.6734  -15.9089
            3   C1y C    19.3401  -15.4757
            4   C1x C    18.5160  -16.6098
            5   O2x O    19.3401  -17.7440
            6   C1y C    22.0067  -17.7440
            7   C1x C    22.8307  -16.6098
            8   O2x O    22.0067  -15.4757
            9   O2a O    22.4361  -19.0654
            10  O2a O    18.9107  -14.1543
            11  N2b N    17.4407  -14.1543 #+
            12  O3a O    16.7319  -12.9265 #-
            13  O3a O    16.7441  -15.3605
            14  N2b N    23.8361  -19.0654 #+
            15  O3a O    24.5334  -20.2728 #-
            16  O3a O    24.5550  -17.7490
BOND        17
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     1   6 1
            7     6   7 1
            8     7   8 1
            9     2   8 1
            10    6   9 1 #Up
            11    3  10 1 #Down
            12   10  11 1
            13   11  12 1
            14   11  13 2
            15    9  14 1
            16   14  15 1
            17   14  16 2

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