KEGG   DRUG: Isosorbide dinitrate
Entry
D00516                      Drug                                   

Name
Isosorbide dinitrate (JP18/USP/INN);
Dilatrate-sr (TN);
Isordil (TN)
Product
  Generic
ISOSORBIDE DINITRATE (American Health Packaging), ISOSORBIDE DINITRATE (Aphena Pharma Solutions - Tennessee), ISOSORBIDE DINITRATE (AvKARE), ISOSORBIDE DINITRATE (AvPAK), ISOSORBIDE (BluePoint Laboratories), ISOSORBIDE DINITRATE (Bryant Ranch Prepack), ISOSORBIDE DINITRATE (Cadila Healthcare Limited), ISOSORBIDE DINITRATE (Cardinal Health), ISOSORBIDE DINITRATE (Golden State Medical Supply), ISOSORBIDE DINITRATE (Hikma Pharmaceuticals USA), ISOSORBIDE DINITRATE (Major Pharmaceuticals), ISOSORBIDE DINITRATE (McKesson Corporation dba SKY Packaging), ISOSORBIDE DINITRATE (NCS HealthCare of KY), ISOSORBIDE DINITRATE (Northstar Rx LLC), ISOSORBIDE DINITRATE (Par Pharmaceutical), ISOSORBIDE DINITRATE (REMEDYREPACK), ISOSORBIDE DINITRATE (REMEDYREPACK), ISOSORBIDE DINITRATE (REMEDYREPACK), ISOSORBIDE DINITRATE (REMEDYREPACK), ISOSORBIDE DINITRATE (Sandoz), ISOSORBIDE DINITRATE (Zydus Pharmaceuticals (USA))
Formula
C6H8N2O8
Exact mass
236.0281
Mol weight
236.1363
Structure
Simcomp
Class
Cardiovascular agent
 DG01657  Nitrovasodilator
Remark
Same as: C07456
Therapeutic category: 2171
ATC code: C01DA08 C05AE02
Chemical structure group: DG01270
Product (DG01270): D00516<JP/US> D00630<JP/US>
Product (mixture): D10209<US>
Efficacy
Vasodilator (coronary)
  Disease
Angina pectoris [DS:H01632]
Comment
Organic nitrate
Osmotic diuretics
Nitric oxide donor
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01D VASODILATORS USED IN CARDIAC DISEASES
    C01DA Organic nitrates
     C01DA08 Isosorbide dinitrate
      D00516  Isosorbide dinitrate (JP18/USP/INN) <JP/US>
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AE Muscle relaxants
     C05AE02 Isosorbide dinitrate
      D00516  Isosorbide dinitrate (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Vasodilators
   Direct-acting Arterial/Venous
    Isosorbide Dinitrate
     D00516  Isosorbide dinitrate (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   217  Vasodilators
    2171  Coronary dilators
     D00516  Isosorbide dinitrate (JP18/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00516  Isosorbide dinitrate
  D00516  Isosorbide dinitrate tablets
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00516
Other DBs
CAS: 87-33-2
PubChem: 7847582
ChEBI: 6061
ChEMBL: CHEMBL6622
DrugBank: DB00883
LigandBox: D00516
NIKKAJI: J3.899G
LinkDB
KCF data

ATOM        16
            1   C1y C    20.6734  -17.3108
            2   C1y C    20.6734  -15.9089
            3   C1y C    19.3401  -15.4757
            4   C1x C    18.5160  -16.6098
            5   O2x O    19.3401  -17.7440
            6   C1y C    22.0067  -17.7440
            7   C1x C    22.8307  -16.6098
            8   O2x O    22.0067  -15.4757
            9   O2a O    22.4361  -19.0654
            10  O2a O    18.9107  -14.1543
            11  N2b N    17.4407  -14.1543 #+
            12  O3a O    16.7319  -12.9265 #-
            13  O3a O    16.7441  -15.3605
            14  N2b N    23.8361  -19.0654 #+
            15  O3a O    24.5334  -20.2728 #-
            16  O3a O    24.5550  -17.7490
BOND        17
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     1   6 1
            7     6   7 1
            8     7   8 1
            9     2   8 1
            10    6   9 1 #Up
            11    3  10 1 #Down
            12   10  11 1
            13   11  12 1
            14   11  13 2
            15    9  14 1
            16   14  15 1
            17   14  16 2

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