KEGG   DRUG: Propylthiouracil
Entry
D00562                      Drug                                   
Name
Propylthiouracil (JP18/USP/INN);
Propylthiouracil (TN)
Product
PROPYLTHIOURACIL (American Health Packaging), PROPYLTHIOURACIL (Endo USA)
  Generic
PROPYLTHIOURACIL (Actavis Pharma), PROPYLTHIOURACIL (Bryant Ranch Prepack), PROPYLTHIOURACIL (Chartwell RX), PROPYLTHIOURACIL (Macleods Pharmaceuticals Limited), PROPYLTHIOURACIL (QUAGEN PHARMACEUTICALS LLC), PROPYLTHIOURACIL (Teva Pharmaceuticals)
Formula
C7H10N2OS
Exact mass
170.0514
Mol weight
170.23
Structure
Simcomp
Class
Hormonal agent
 DG01934  Antithyroid agent
Remark
Same as: C07569
Therapeutic category: 2432
ATC code: H03BA02
Product: D00562<JP/US>
Efficacy
Antithyroid, Thyroid hormone synthesis inhibitor
  Disease
Graves' disease [DS:H00082]
Hyperthyroidism [DS:H01645]
Target
TPO [HSA:7173] [KO:K00431]
DIO1 [HSA:1733] [KO:K01562]
DIO2 [HSA:1734] [KO:K17904]
  Pathway
hsa04918  Thyroid hormone synthesis
hsa04919  Thyroid hormone signaling pathway
hsa05320  Autoimmune thyroid disease
  Network
nt06322  TRH-TSH-TH signaling
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H03 THYROID THERAPY
   H03B ANTITHYROID PREPARATIONS
    H03BA Thiouracils
     H03BA02 Propylthiouracil
      D00562  Propylthiouracil (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Suppressant (Thyroid)
  Antithyroid Agents
   Propylthiouracil
    D00562  Propylthiouracil (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   243  Thyroid and parathyroid hormone preparations
    2432  Antithyroid hormones
     D00562  Propylthiouracil (JP18/USP/INN)
Drug groups [BR:br08330]
 Hormonal agent
  DG01934  Antithyroid agent
   D00562  Propylthiouracil
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Peroxidase
    TPO
     D00562  Propylthiouracil (JP18/USP/INN) <JP/US>
   Thyroxine 5'-deiodinase
    DIO1
     D00562  Propylthiouracil (JP18/USP/INN) <JP/US>
    DIO2
     D00562  Propylthiouracil (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00562  Propylthiouracil
  D00562  Propylthiouracil tablets
Other DBs
CAS: 51-52-5
PubChem: 7847628
ChEBI: 8502
PDB-CCD: 3CJ[PDBj]
LigandBox: D00562
NIKKAJI: J1.363C
LinkDB
KCF data

ATOM        11
            1   C8y C    25.3173  -19.8324
            2   C8x C    25.3173  -18.4289
            3   N4x N    26.5346  -20.5256
            4   C1b C    24.1060  -20.5256
            5   C8y C    26.5346  -17.7243
            6   C8y C    27.7461  -19.8324
            7   C1b C    22.8887  -19.8324
            8   N4x N    27.7461  -18.4289
            9   O5x O    26.5346  -16.3265
            10  S0  S    28.9574  -20.5256
            11  C1a C    21.6774  -20.5313
BOND        11
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     5   9 2
            9     6  10 2
            10    7  11 1
            11    6   8 1

» Japanese version   » Back

DBGET integrated database retrieval system