KEGG   DRUG: Fexofenadine hydrochloride
Entry
D00671                      Drug                                   
Name
Fexofenadine hydrochloride (JP18/USP);
Allegra (TN)
Formula
C32H39NO4. HCl
Exact mass
537.2646
Mol weight
538.11
Structure
Simcomp
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Dermatological agent
 DG03243  Atopic dermatitis agent
Remark
Therapeutic category: 4490
ATC code: R06AX26
Chemical structure group: DG01117
Product (DG01117): D00671<JP>
Product (mixture): D10252<JP>
Efficacy
Antiallergic, H1 receptor antagonist
  Disease
Seasonal allergic rhinitis [DS:H01360]
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Interaction
Structure map
map07212  Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AX Other antihistamines for systemic use
     R06AX26 Fexofenadine
      D00671  Fexofenadine hydrochloride (JP18/USP) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D00671  Fexofenadine hydrochloride (JP18/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for otolaryngologic use
  69 Oral medicine for nasal inflammation
   D00671  Fexofenadine hydrochloride (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Fexofenadine
    D00671  Fexofenadine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    DG01117  Fexofenadine
     D00671  Fexofenadine hydrochloride
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D00671  Fexofenadine hydrochloride
Drug classes [BR:br08332]
 Anti-allergic agent
  DG01482  Histamine receptor H1 antagonist
   D00671  Fexofenadine hydrochloride
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D00671  Fexofenadine hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D00671  Fexofenadine hydrochloride (JP18/USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00671  Fexofenadine hydrochloride
  D00671  Fexofenadine hydrochloride tablets
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00671
Rx-to-OTC switch list in the USA [br08315.html]
 D00671
Rx-to-OTC switch list in Japan [br08314.html]
 D00671
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    DG01117  Fexofenadine
Other DBs
CAS: 153439-40-8
PubChem: 7847737
ChEBI: 5051
LigandBox: D00671
NIKKAJI: J871.596C
LinkDB
KCF data

ATOM        38
            1   C8x C     4.7600  -25.5500
            2   C8x C     4.7600  -26.9500
            3   C8x C     5.9724  -27.6500
            4   C8x C     7.1849  -26.9500
            5   C8y C     7.1849  -25.5500
            6   C8x C     5.9724  -24.8500
            7   C8x C     9.6097  -26.9500
            8   C8y C     9.6097  -25.5500
            9   C1d C     8.3973  -24.8500
            10  C8x C    10.8222  -27.6500
            11  C8x C    12.0346  -26.9500
            12  C8x C    12.0346  -25.5500
            13  C8x C    10.8222  -24.8500
            14  C1y C     8.3973  -23.4500
            15  C1x C     9.6118  -22.7488
            16  C1x C     9.6118  -21.3488
            17  N1y N     8.3993  -20.6488
            18  C1x C     7.1849  -21.3500
            19  C1x C     7.1849  -22.7500
            20  O1a O     7.1849  -24.1500
            21  C1b C     8.3993  -19.2500
            22  C1b C     9.6123  -18.5497
            23  C1b C    10.8080  -19.2402
            24  C1c C    11.9952  -18.5549
            25  C8y C    13.1865  -19.2429
            26  O1a O    11.9954  -17.1502
            27  C8x C    13.1865  -20.6497
            28  C8x C    14.3989  -21.3498
            29  C8y C    15.6113  -20.6498
            30  C8x C    15.6114  -19.2430
            31  C8x C    14.3990  -18.5429
            32  C1d C    16.8228  -21.3493
            33  C6a C    18.0178  -20.6593
            34  O6a O    19.2053  -21.3450
            35  O6a O    18.0179  -19.2503
            36  C1a C    15.8329  -22.3393
            37  C1a C    17.8128  -22.3393
            38  X   Cl   16.5900  -25.3400
BOND        40
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    9  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   14  19 1
            22    9  20 1
            23   17  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   24  26 1
            29   25  27 2
            30   27  28 1
            31   28  29 2
            32   29  30 1
            33   30  31 2
            34   25  31 1
            35   29  32 1
            36   32  33 1
            37   33  34 1
            38   33  35 2
            39   32  36 1
            40   32  37 1

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